DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PNPLA7 and nte1

DIOPT Version :9

Sequence 1:	XP_006717165.1	Gene:	PNPLA7 / 375775	HGNCID:	24768	Length:	1343	Species:	Homo sapiens
Sequence 2:	NP_588086.1	Gene:	nte1 / 2539411	PomBaseID:	SPCC4B3.04c	Length:	1316	Species:	Schizosaccharomyces pombe

Alignment Length:	1284	Identity:	391/1284 - (30%)
Similarity:	594/1284 - (46%)	Gaps:	220/1284 - (17%)

- Green bases have known domain annotations that are detailed below.

Human   125 RFKKEYPALQPKEPPPSLLEADL-TEFDVKNSHLPSEVLYMLKN--------VRVLGHFEKPLFL 180
            |:..:|..| |.|.|  :.||.| .:.:::    |||.....:|        :.:.|:.|||:|:
pombe    85 RYLNKYARL-PHEAP--IKEAKLGPDTNIR----PSEPRIGFQNYLDEFLSAISIFGYLEKPVFV 142

Human   181 ELCKHIVFVQLQEGEHVFQPREPDPSICVVQDGRLEVCIQ-----DTDGTEVV----------VK 230
            ||.:||...::.||..::...:  .|..:|.||    |.|     :.|..|||          :.
pombe   143 ELARHIRTQRVAEGNTIYLGEQ--SSFILVVDG----CFQVFTAPEKDSAEVVEEAGQPEYRLLT 201

Human   231 EVLAGDSVHSLLSILDII-------TGHAAPYKT------------------------------- 257
            ||..|..:.|..::|::.       |....|:|:
pombe   202 EVSNGAPLSSFFTVLELFTELIPEATSKENPFKSTTSSLRPGSSTTTEAGANNASKPHMPQPKKA 266

Human   258 -VSVRAAIPSTILRLPAAAFHGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNAES 321
             :..:|.|.:||..:||.|||.:..|:|.:..::||:|:.|.|||||...:.||||:..:|:.|.
pombe   267 RIIAKAKIDTTIAVIPANAFHHLVHKFPNSSAQIVQVILTRFQRVTFSTGYEYLGLSDAIFSIEK 331

Human   322 QAIPLVS------------------VASVAAGKAKKQVFY-----GEEERLKKPPRLQESCDSAD 363
            ....|.:                  ..|....:|..:.|.     |.:.||.. ....::.|. :
pombe   332 NFNSLTAYELPNYIRSDIIDDFKKEAMSEHLSQASNESFIVLRSKGAQSRLSN-QYFSKAFDK-E 394

Human   364 HGG------GRPAAAGPLLKRSH------SVPAPSIRKQILEELEKPGAGDPDPSAP--QGGPGS 414
            ||.      ...|.||.||..::      |.....:||..|........||.|.||.  .|....
pombe   395 HGNFVSDIDRSTANAGDLLSSTNPHSTLLSTSVGPLRKFPLNRSYSREVGDYDISASFRDGLLQC 459

Human   415 ATSDLGMACDRARVF---LHSD------EHPGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLA 470
            ....||       ||   |..|      |:..|...|.|.|.|   :....::..|.:..:|.
pombe   460 IFKSLG-------VFNYELKEDNDDLCTENDSSEGDSDSLKKV---DFLGQIAMMSATDREEV-- 512

Human   471 SRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHVPAGTVVSRQGDQDASILFVVSGLLHV--- 532
              ||..:....|..:|...|         .:.::....||.:.||||....:.:::.|.|..
pombe   513 --KSSIVVSTKKSTILEFAK---------EIEIIFYKKGTTIVRQGDHADGLYYIIDGFLDATCP 566

Human   533 --------YQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIM 589
                    |...:|...    |:.:||.:|...|.::.......|.|..|.....:.::....|:
pombe   567 SKLTFSTSYDTDLGMHS----FMIKPGGIVNYQACVSNYRSFINVTARSDVLVGFLPRSCLERII 627

Human   590 RKQPTVVLGVAHTVVKRMSSFVRQIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKD 654
            .::|.:.|.:|..::..:.|.:.::|||:.|:.:...:.:|.:.|.|||.|::|:||||| |..:
pombe   628 DQEPLISLTIAKRLISLVPSLLLKLDFAVGWIHLNPDQVVYEKNDPSDCVYVVLNGRLRS-IEDE 691

Human   655 DGKKRLA----GEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQV---- 711
            .|..|..    .|||:||.||.:|.|.:..|::|:.|:|||||||:|.....::...:|.|
pombe   692 RGSARTQVDYFNEYGKGDSVGELEMLLNNRRSSTLFAIRDSELAKIPETLFNALSLSHPAVGLQL 756

Human   712 ----VTRLIHLLGEKILGSLQQGPVTGHQLGLPTEGSKWDLGNPAVNLSTVAVMPVSEEVPLTAF 772
                ..|:..||..|.:..:|..|...|                  ::.|:|::|.|....|..|
pombe   757 SKIIANRMNLLLNNKSMDGMQHQPHEKH------------------SIRTLAIVPSSSTGLLILF 803

Human   773 ALELEHALSAIGPTL-LLTSDNIKRRLGSAALDSVHEYRLSSWLGQQEDTHRIVLYQAD-GTLTP 835
            :.:|...||.:|.:: :|...::...||..|...:..::|||:|...||.:.|::|.|| |..:.
pombe   804 SQKLTSVLSVMGKSVKVLRQSSVLEHLGKHAFSRMGRFKLSSYLSDLEDKYDILIYVADSGVGSA 868

Human   836 WTQRCVRQADCILIVGLGDQEPTVGELERMLESTAVRAQKQLILLHREEGPAPARTVEWLNMRSW 900
            |.|.|:||||||.|:...||.|.:||.|:.|.:....|:|:|:|||.|.......|..||..|.|
pombe   869 WLQTCIRQADCIYILAEADQNPNIGEYEQHLIAMKSTARKELVLLHPERFCPSGLTRLWLKERPW 933

Human   901 CSGHLHLCC------------PRRVFSRRSLPKLVEM---------YKH---VFQRPPDRHSDFS 941
            ...|.|:..            ..:||......|:..:         :||   |:|....:.|||:
pombe   934 VYAHHHVQLRIGLDNEISQNNEAKVFLNIIRAKVQNLHYGFRKYIDWKHLHPVYQANRAQDSDFA 998

Human   942 RLARVLTGNAIALVLGGGGARGCAQVGVLKALAECGIPVDMVGGTSIGAFVGALYSEERNYSQMR 1006
            ||||.:.|.|||||||||||||.:|:|:|.||.|.|||.|::||||||||.|.||:.|.:...|.
pombe   999 RLARRICGKAIALVLGGGGARGISQIGILYALEEAGIPFDIIGGTSIGAFNGGLYAWEADLVPMF 1063

Human  1007 IRAKQWAEGMTSLMKAALDLTYPITSMFSGAGFNSSIFSVFKDQQIEDLWIPYFAITTDITASAM 1071
            .|||::...|.:|.:..||:|||..:..:|..||..|:..|.:..|||.|:|::|.||:||.|.|
pombe  1064 GRAKKFCGRMANLWRFVLDVTYPQAAYTTGHEFNRGIWKTFGEIHIEDFWLPFYANTTNITHSRM 1128

Human  1072 RVHTDGSLWWYVRASMSLSGYMPPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRD 1136
            .:|:.|..|.|:||||||:|.:||:.. ..|.:|:||||::||.....:|:||..:.||||||.|
pombe  1129 DIHSSGYAWRYIRASMSLAGLVPPMLS-DSGDMLLDGGYMDNLTVSHMQSLGASSIFAIDVGSED 1192

Human  1137 ETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQTRLAYVCCVRQLEVVKSSDYCEYLRPPI 1201
            ..:..:|||.:||.|.|..||.|...|....::||||:||.||..|...|.|||...|.|:|||:
pombe  1193 SREPMHYGDTVSGVWALISRWIPFIPKTSFPSLAEIQSRLTYVTSVATGEKVKSMPGCFYMRPPV 1257

Human  1202 DSYSTLDFGKFNEICEVGYQHGRTVFDIWGRSGVLEKMLRDQQGPSKKP 1250
            ..:.||:||.|.:|..|||.:|:...:....|..|:.:|..:....:.|
pombe  1258 KDFPTLEFGSFEKIYNVGYNYGKEYVEKLKTSHKLDDILSPRDTSKRHP 1306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PNPLA7	XP_006717165.1	Crp	164..>306	CDD:223736	50/203 (25%)
		CAP_ED	170..291	CDD:237999	40/174 (23%)
		Crp	485..>614	CDD:223736	25/139 (18%)
		CAP_ED	485..593	CDD:237999	21/118 (18%)
		Crp	607..>724	CDD:223736	46/128 (36%)
		CAP_ED	608..716	CDD:237999	43/119 (36%)
		Pat_PNPLA6_PNPLA7	937..1242	CDD:132864	144/304 (47%)
		RssA	942..1243	CDD:224666	141/300 (47%)
nte1	NP_588086.1	CAP_ED	132..294	CDD:294041	39/167 (23%)
		CAP_ED	522..638	CDD:237999	24/128 (19%)
		Crp	526..>650	CDD:223736	25/136 (18%)
		CAP_ED	641..756	CDD:237999	42/115 (37%)
		Crp	643..>777	CDD:223736	46/134 (34%)
		RssA	998..1304	CDD:224666	141/306 (46%)
		Pat_Fungal_NTE1	999..1268	CDD:132865	132/269 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	167	1.000	Domainoid score	I1051
eggNOG	1	0.900	-	-		E1_COG0664
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	544	1.000	Inparanoid score	I240
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001797
OrthoInspector	1	1.000	-	-		otm53553
orthoMCL	1	0.900	-	-		OOG6_101855
Panther	1	1.100	-	-	LDO	PTHR14226
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R845
SonicParanoid	1	1.000	-	-		X1325
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.850