DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PNPLA7 and Pnpla7

DIOPT Version :9

Sequence 1:	XP_006717165.1	Gene:	PNPLA7 / 375775	HGNCID:	24768	Length:	1343	Species:	Homo sapiens
Sequence 2:	NP_653339.2	Gene:	Pnpla7 / 246246	RGDID:	708466	Length:	1349	Species:	Rattus norvegicus

Alignment Length:	1338	Identity:	1103/1338 - (82%)
Similarity:	1196/1338 - (89%)	Gaps:	7/1338 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEEEKDDSPQADFCLGTALHSWGLWFTEEGSPSTMLTGIAVGALLALALVGVLILFMFRRLRQFR 65
            |::|:|..|:|.:||||||.||||.|.||.|.||||.||.:|.||.||.||:...|::|::.:||
  Rat     1 MQKEEDVCPEAGYCLGTALSSWGLHFMEEHSQSTMLMGIGIGVLLTLAFVGLAAFFVYRKVSRFR 65

Human    66 QAQPTPQYRFRKRDKVMFYGRKIMRKVTTLPNTLVENTALPRQRARKRTKVLSLAKRILRFKKEY 130
            :|:||||||||||||||||||||||||||||:|||.|||.||||.||||||||||||||||||||
  Rat    66 RAEPTPQYRFRKRDKVMFYGRKIMRKVTTLPHTLVGNTAAPRQRVRKRTKVLSLAKRILRFKKEY 130

Human   131 PALQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHIVFVQLQEGE 195
            |.|||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||
  Rat   131 PTLQPKEPPPSLLEADLTEFDVKNSHLPSEVLYMLKNVRVLGHFEKPLFLELCKHMVFVQLQEGE 195

Human   196 HVFQPREPDPSICVVQDGRLEVCIQDTDGTEVVVKEVLAGDSVHSLLSILDIITGHAAPYKTVSV 260
            |||||.|||.||.|||||||||||||.|||||||||||.||||||||||||:||||.|||||||.
  Rat   196 HVFQPGEPDISIYVVQDGRLEVCIQDADGTEVVVKEVLPGDSVHSLLSILDVITGHTAPYKTVSA 260

Human   261 RAAIPSTILRLPAAAFHGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNAESQAIP 325
            |||:.||:|.||||||.|||||||||||||||||||||||||||||||||||||||||.||||||
  Rat   261 RAAVASTVLWLPAAAFQGVFEKYPETLVRVVQIIMVRLQRVTFLALHNYLGLTTELFNPESQAIP 325

Human   326 LVSVASVAAGKAKKQVFYGEEERLKKPPRLQESCDSADHGGGRPAAAGPLLKRSHSVPAPSIRKQ 390
            |:||||| ||:||:|:.||.||:|::.|||.| .:|:|...  .|.:|||||||.|||.|.|..:
  Rat   326 LLSVASV-AGRAKRQMSYGPEEQLERSPRLSE-FNSSDQRS--VAVSGPLLKRSCSVPLPPIHGE 386

Human   391 ILEELEKPGAGDPDPSAPQGGPGSATSDLGMACDRARVFLHSDEHPGSSVASKSRKSVMVAEIPS 455
            |.|..:..|:|. :.||.|.....||||||||.:|||:..||:|..|||:||||:||| ||| .|
  Rat   387 IDELRQAQGSGS-NTSAFQESQEGATSDLGMAYNRARILPHSEEQLGSSLASKSKKSV-VAE-TS 448

Human   456 TVSQHSESHTDETLASRKSDAIFRAAKKDLLTLMKLEDSSLLDGRVALLHVPAGTVVSRQGDQDA 520
            .|..:||...||...|.::|||||||.|||||||||:|.||||||||.|||||||:||:|||||.
  Rat   449 AVFHYSEKPRDEPGPSGRTDAIFRAATKDLLTLMKLDDPSLLDGRVAFLHVPAGTIVSKQGDQDV 513

Human   521 SILFVVSGLLHVYQRKIGSQEDTCLFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHF 585
            :|||||||:|||||:||.|.||||||||.||||||||||||||||:||::|||||||||||||||
  Rat   514 NILFVVSGMLHVYQQKIDSLEDTCLFLTHPGEMVGQLAVLTGEPLMFTIRANRDCSFLSISKAHF 578

Human   586 YEIMRKQPTVVLGVAHTVVKRMSSFVRQIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSV 650
            ||||||:|.||||||||||:|||||||||||||||:||||||||||||||||||||:||||||||
  Rat   579 YEIMRKRPDVVLGVAHTVVRRMSSFVRQIDFALDWMEVEAGRAIYRQGDKSDCTYIVLSGRLRSV 643

Human   651 IRKDDGKKRLAGEYGRGDLVGVVETLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRL 715
            ||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||||||||
  Rat   644 IRKDDGKKRLAGEYGRGDLVGVVEMLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRL 708

Human   716 IHLLGEKILGSLQQGPVTGHQLGLPTEGSKWDLGNPAVNLSTVAVMPVSEEVPLTAFALELEHAL 780
            |||||||||||||||..||||||..|..||||||||..||||||.|||||:||||||||||:|||
  Rat   709 IHLLGEKILGSLQQGSGTGHQLGFNTASSKWDLGNPPGNLSTVAAMPVSEDVPLTAFALELQHAL 773

Human   781 SAIGPTLLLTSDNIKRRLGSAALDSVHEYRLSSWLGQQEDTHRIVLYQADGTLTPWTQRCVRQAD 845
            |||||.|||||||||:|||||||||:||||||||||||||.|||||||||.|||||||||:||||
  Rat   774 SAIGPVLLLTSDNIKQRLGSAALDSIHEYRLSSWLGQQEDIHRIVLYQADSTLTPWTQRCIRQAD 838

Human   846 CILIVGLGDQEPTVGELERMLESTAVRAQKQLILLHREEGPAPARTVEWLNMRSWCSGHLHLCCP 910
            ||||||||||||.:||||:|||||||||||||||||:||||||:|||||||||||||||||||||
  Rat   839 CILIVGLGDQEPALGELEQMLESTAVRAQKQLILLHKEEGPAPSRTVEWLNMRSWCSGHLHLCCP 903

Human   911 RRVFSRRSLPKLVEMYKHVFQRPPDRHSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKALAE 975
            |||||:||||||||||..:||||||||||||||||:||||||||||||||||||||||:|:||||
  Rat   904 RRVFSKRSLPKLVEMYTRIFQRPPDRHSDFSRLARILTGNAIALVLGGGGARGCAQVGILRALAE 968

Human   976 CGIPVDMVGGTSIGAFVGALYSEERNYSQMRIRAKQWAEGMTSLMKAALDLTYPITSMFSGAGFN 1040
            ||||||::||||||||:|||::|||:|||:|||||||||.|||::|..|||||||||||||.|||
  Rat   969 CGIPVDIIGGTSIGAFMGALFAEERSYSQIRIRAKQWAEDMTSMVKTILDLTYPITSMFSGTGFN 1033

Human  1041 SSIFSVFKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSLSGYMPPLCDPKDGHLL 1105
            |||.::|||:||||||:|||||||||||||||||||||||.||||||||||||||||||||||||
  Rat  1034 SSISNIFKDRQIEDLWLPYFAITTDITASAMRVHTDGSLWRYVRASMSLSGYMPPLCDPKDGHLL 1098

Human  1106 MDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMA 1170
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1099 MDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMA 1163

Human  1171 EIQTRLAYVCCVRQLEVVKSSDYCEYLRPPIDSYSTLDFGKFNEICEVGYQHGRTVFDIWGRSGV 1235
            ||||||||||||||||:||:||||||||||||||.|||||||:|||||||||||||||||.||||
  Rat  1164 EIQTRLAYVCCVRQLEMVKNSDYCEYLRPPIDSYRTLDFGKFDEICEVGYQHGRTVFDIWVRSGV 1228

Human  1236 LEKMLRDQQGPSKKPASAVLTCPNASFTDLAEIVSRIEPAKPAMVDDESDYQTEYEEELLDVPRD 1300
            |||||:||||.||:....|.||||:||||||||||||||||.|.|||||||||||||||..:|::
  Rat  1229 LEKMLQDQQGTSKRKDCGVFTCPNSSFTDLAEIVSRIEPAKVAAVDDESDYQTEYEEELPAIPKE 1293

Human  1301 AYADFQSTSAQQGSDLEDESSLRHRHPSLAFPKLSEGS 1338
            .|||||||..:..||.|.|.|:.....||..||.|:.|
  Rat  1294 TYADFQSTGIELDSDSECEPSMSQGPHSLTSPKQSQDS 1331

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PNPLA7	XP_006717165.1	Crp	164..>306	CDD:223736	127/141 (90%)
		CAP_ED	170..291	CDD:237999	106/120 (88%)
		Crp	485..>614	CDD:223736	110/128 (86%)
		CAP_ED	485..593	CDD:237999	92/107 (86%)
		Crp	607..>724	CDD:223736	113/116 (97%)
		CAP_ED	608..716	CDD:237999	104/107 (97%)
		Pat_PNPLA6_PNPLA7	937..1242	CDD:132864	277/304 (91%)
		RssA	942..1243	CDD:224666	272/300 (91%)
Pnpla7	NP_653339.2	Crp	164..>306	CDD:223736	127/141 (90%)
		CAP_ED	170..291	CDD:237999	106/120 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..361		10/21 (48%)
		Crp	478..>607	CDD:223736	110/128 (86%)
		CAP_ED	478..588	CDD:237999	93/109 (85%)
		Crp	600..>729	CDD:223736	123/128 (96%)
		CAP_ED	601..709	CDD:237999	104/107 (97%)
		Involved in the binding to lipid droplets. /evidence=ECO:0000250\|UniProtKB:A2AJ88	678..964		257/285 (90%)
		Pat_PNPLA6_PNPLA7	930..1235	CDD:132864	277/304 (91%)
		RssA	935..1221	CDD:224666	259/285 (91%)
		GXGXXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	951..956		4/4 (100%)
		GXSXG. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	978..982		3/3 (100%)
		DGA/G. /evidence=ECO:0000255\|PROSITE-ProRule:PRU01161	1100..1102		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1297..1349		16/35 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83680810
Domainoid	1	1.000	456	1.000	Domainoid score	I8768
eggNOG	1	0.900	-	-		E1_COG0664
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62431
Inparanoid	1	1.050	2121	1.000	Inparanoid score	I1227
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG48868
OrthoDB	1	1.010	-	-		D18227at32523
OrthoFinder	1	1.000	-	-		FOG0001797
OrthoInspector	1	1.000	-	-		oto130558
orthoMCL	1	0.900	-	-		OOG6_101855
Panther	1	1.100	-	-	LDO	PTHR14226
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1325
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	17.310