DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PNPLA7 and ZK370.4

DIOPT Version :9

Sequence 1:	XP_006717165.1	Gene:	PNPLA7 / 375775	HGNCID:	24768	Length:	1343	Species:	Homo sapiens
Sequence 2:	NP_498927.2	Gene:	ZK370.4 / 176225	WormBaseID:	WBGene00022718	Length:	1353	Species:	Caenorhabditis elegans

Alignment Length:	1352	Identity:	494/1352 - (36%)
Similarity:	708/1352 - (52%)	Gaps:	261/1352 - (19%)

- Green bases have known domain annotations that are detailed below.

Human    74 RFRKRDKVMFYGRKIMRK-VTTLP--------------NTLVENTALPRQRA-------RKRTKV 116
            |.||||    :.:|:.:. |...|              |.::...::||:|:       |:::..
Worm   127 RMRKRD----WAKKLYKSLVQDSPGRTPTDESSDEENANVVMGGGSVPRRRSKHGNSSRRRQSTA 187

Human   117 LSLAKRILRFKKEYPALQPKE--------PPPSLLE-ADLTEFDVKNSHLPSEVLYMLKNVRVLG 172
            ..|||.::|........|.:|        ||....| .||.|..   .:|..|:.|:|.|:::|
Worm   188 FQLAKDLIRRGSRSYFRQNQENNKDTRVRPPQEFFEPTDLPEIP---QNLQPEIFYILHNLKML- 248

Human   173 HFEKPLFLELCKHIVFVQ-LQEGEHVFQPREPDPSICVVQDGRLEVCIQDTDGTEVVVKEVLAGD 236
              |.|...:|....:.|: .|.|:::.:|.|.|.:|.|..||.|.|.|:..:|.|.:||.:.||.
Worm   249 --ELPSEWKLDPREIEVRSFQAGDYIVKPGESDDAIYVAIDGELTVHIRHMEGKEYLVKCIPAGG 311

Human   237 SVHSLLSILDIITGHAAPYKTVSVRAAIPSTILRLPAAAFHGVFEKYPETLVRVVQIIMVRLQRV 301
            |..||||:|||:....:.::||:::||.|..:.:.|..:|...:.|.||..:|.:||::.||..|
Worm   312 SFFSLLSMLDILMDFPSIFRTVALKAADPCRVAKFPITSFRESYHKNPEAWIRPIQIVITRLLHV 376

Human   302 TFLALHNYLGLTTELFNAESQAIPLVSVASVAAGKAKKQVFYGEEERLKKPPRLQESCDSADHGG 366
            |...||.|:||::||.....                       :::|.:.
Worm   377 TLTTLHQYMGLSSELMRRRR-----------------------DDDRHRN--------------- 403

Human   367 GRPAAAGPLLKRSHSVPAPSIRKQILEELEKPGAGDPDPSAPQGGPGSATSDLGMACDRARVFLH 431
                                                          ||:||.|.:
Worm   404 ----------------------------------------------GSSTSKLQL---------- 412

Human   432 SDEHPGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLASRKSDA-IFRAAKKDLLTLMKLEDSS 495
                   |::.|.:      |.|..::.:.:   |:.:.:||..| .|.....|::       |.
Worm   413 -------SLSLKKK------EKPFNINDNEQ---DQLIVARKWMAEAFGLVADDVV-------SE 454

Human   496 LLDGRVALLHVPAGTVVSRQGDQDASILFVVSGLL----------------HVYQRKIGSQEDTC 544
            .:..::.|....||.|:..||.::..::.|:.|.|                .::..:...::::.
Worm   455 QIGSKIHLESYEAGHVIIEQGAEEEVLMMVLHGNLILAQYGSDFFAQIERESLFDEENNEEDESA 519

Human   545 LFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVKRMSS 609
            :......|:||.|.:||.||..:|::|........:.|..|...:...|.:.|.|||:|::|:|.
Worm   520 VIRVTARELVGGLQILTNEPSFYTIRAAVQTRVAIMKKKDFSAFLEAHPEIYLPVAHSVLRRLSP 584

Human   610 FVRQIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVE 674
            |:|.:|||||||.|::|.|.||.||.:|..:::||||||||     .||.:..|:||||::|::|
Worm   585 FLRGVDFALDWVLVDSGHACYRAGDMADSLFVVLSGRLRSV-----EKKTVVEEFGRGDVLGMME 644

Human   675 TLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGPVTGHQLGL 739
            .||.:.|||||.|||.|:||::|.|.|..||.:||||..||:.|||:....:.::.|.....:..
Worm   645 VLTKKPRATTVLAVRFSQLARVPEGLLNFIKMQYPQVGFRLVQLLGQYYSQTNRRAPFAAPTVIR 709

Human   740 PTEGSKWDLGNPAVNLSTVAVMPVSEEVPLTAFALELEHALSAIGPTLLLTSDNIKRRLGSAALD 804
            ..|....|..:...||.|:||:|.|.:|||..|..||.||||:....|.|:|..:...|..:.|:
Worm   710 TNELGATDPMSHIKNLHTIAVVPASPDVPLVPFTCELYHALSSNLRVLRLSSQKVAACLDPSVLE 774

Human   805 SVHEYRLSSWLGQQEDTHRIVLYQADGTLTPWTQRCVRQADCILIVGLGDQEPTVGELERML--- 866
            ...::||..||..||||:.:|:|:.|.|.|.||:||:||||.||:|.:|.:.|....|.|.|
Worm   775 KQADFRLMHWLNVQEDTYPLVIYECDFTQTNWTRRCLRQADAILVVAIGGKTPEKQTLMRELMNM 839

Human   867 ESTAVRAQKQLILLHREEGPAPARTVEWLNMRSWCSGHLHLCCPRRVFS-RRSLPKL-------- 922
            ....||..|:||||..|....|:.|:|||. .|:.|||.|:..|:|:.. .|...|:
Worm   840 NQDGVRTNKELILLWPESTKTPSGTIEWLK-NSYFSGHHHIRAPKRMLQWNRKFRKMSRAEVMTP 903

Human   923 -------VEMY-KHVFQRPPDRHSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKALAECGIP 979
                   :|.| |:||. .|||.||||||||:||||||.||||||||||.|.||||:||.|.|||
Worm   904 TSVENEVIEYYEKNVFW-TPDRRSDFSRLARILTGNAIGLVLGGGGARGAAHVGVLRALREEGIP 967

Human   980 VDMVGGTSIGAFVGALYSEERNYSQMRIRAKQWAEGMTSLMKAALDLTYPITSMFSGAGFNSSIF 1044
            ||:|||||||:.:|.||:|..:...:..||..|..||:||.:..|||||..::||:||.||.||.
Worm   968 VDIVGGTSIGSLIGGLYAETPDDVVVETRAASWFNGMSSLWRKLLDLTYAHSAMFTGAQFNFSIK 1032

Human  1045 SVFKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSLSGYMPPLCDPKDGHLLMDGG 1109
            .:|:::.||||||.||.|:|||:.|.||||..|.||.|.||||||:||:||||||:|||||:|||
Worm  1033 DLFEERLIEDLWISYFCISTDISTSEMRVHRSGPLWAYCRASMSLAGYLPPLCDPQDGHLLLDGG 1097

Human  1110 YINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWNPLATKVKVLNMAEIQT 1174
            |:||:||||.|::||:.|||.||||.:||:|.:|||:|||.|:|.||.||..|..::|||.|||:
Worm  1098 YVNNVPADVMRNLGARCVIACDVGSIEETNLYDYGDSLSGMWVLLKRLNPFGTPPRILNMEEIQS 1162

Human  1175 RLAYVCCVRQLEVVKSSDYCEYLRPPIDSYSTLDFGKFNEICEVGYQHGRTVF------DIWGRS 1233
            |||||.|||||||||.:.||.||||||:.:.||||.||.||.|:|.::||...      |   |:
Worm  1163 RLAYVSCVRQLEVVKKASYCRYLRPPIEPFKTLDFPKFQEIMELGLKYGREACHELITND---RA 1224

Human  1234 GVL--EKMLRD---QQGPSKKP--ASAVLTCPNASFTDLAEIVSRIEPAKPA------------- 1278
            |:|  ||..|.   ||...:||  :.||      ||||||..:|:|...:|.
Worm  1225 GILGDEKETRKFKRQQSRREKPDVSRAV------SFTDLAAAMSKIPVVRPTLRHSMSLNPSANG 1283

Human  1279 ---------MVDDESDYQTEYEEELLDVPRDAYADFQSTSAQQGSD--LEDE 1319
                     ::||:....|:|.||            :|:.::.|::  .|||
Worm  1284 PVGRAGDHFLLDDDLFNDTDYYEE------------ESSQSENGNESFTEDE 1323

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PNPLA7	XP_006717165.1	Crp	164..>306	CDD:223736	50/142 (35%)
		CAP_ED	170..291	CDD:237999	42/121 (35%)
		Crp	485..>614	CDD:223736	32/144 (22%)
		CAP_ED	485..593	CDD:237999	22/123 (18%)
		Crp	607..>724	CDD:223736	62/116 (53%)
		CAP_ED	608..716	CDD:237999	58/107 (54%)
		Pat_PNPLA6_PNPLA7	937..1242	CDD:132864	191/312 (61%)
		RssA	942..1243	CDD:224666	188/311 (60%)
ZK370.4	NP_498927.2	CAP_ED	261..364	CDD:237999	37/102 (36%)
		Crp	262..>377	CDD:223736	42/114 (37%)
		CAP_ED	449..570	CDD:237999	24/127 (19%)
		Crp	454..>583	CDD:223736	28/128 (22%)
		CAP_ED	578..686	CDD:237999	60/112 (54%)
		Crp	583..>700	CDD:223736	62/121 (51%)
		Patatin_and_cPLA2	926..1212	CDD:299702	183/285 (64%)
		RssA	950..1229	CDD:224666	167/281 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C161470198
Domainoid	1	1.000	221	1.000	Domainoid score	I1629
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62431
Inparanoid	1	1.050	782	1.000	Inparanoid score	I290
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48868
OrthoDB	1	1.010	-	-		D253518at2759
OrthoFinder	1	1.000	-	-		FOG0001797
OrthoInspector	1	1.000	-	-		mtm5052
orthoMCL	1	0.900	-	-		OOG6_101855
Panther	1	1.100	-	-	LDO	PTHR14226
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R845
SonicParanoid	1	1.000	-	-		X1325
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.940