Protein Alignment PNPLA7 and ZK370.4

DIOPT Version :10

• Sequence 1: XP_047279320.1
• Gene: PNPLA7 / 375775
• HGNCID: 24768
• Length: 1359
• Species: Homo sapiens
• Sequence 2: NP_498927.2
• Gene: ZK370.4 / 176225
• WormBaseID: WBGene00022718
• Length: 1353
• Species: Caenorhabditis elegans
• Alignment Length: 1368
• Identity: 494/1368 - (36%)
• Similarity: 708/1368 - (51%)
• Gaps: 277/1368 - (20%)

Human    74 RFRKRDKVMFYGRKIMRK-VTTLP--------------NTLVENTALPRQRA-------RKRTKV 116
            |.||||    :.:|:.:. |...|              |.::...::||:|:       |:::..
 Worm   127 RMRKRD----WAKKLYKSLVQDSPGRTPTDESSDEENANVVMGGGSVPRRRSKHGNSSRRRQSTA 187

Human   117 LSLAKRILRFKKEYPALQPKE--------PPPSLLE-ADLTEFDVKNSHLPSEVLYMLKNVRVLG 172
            ..|||.::|........|.:|        ||....| .||.|..   .:|..|:.|:|.|:::|
 Worm   188 FQLAKDLIRRGSRSYFRQNQENNKDTRVRPPQEFFEPTDLPEIP---QNLQPEIFYILHNLKML- 248

Human   173 HFEKPLFLELCKHIVFVQ-LQEGEHVFQPREPDPSICVVQDGRLEVCIQDTDGTEVVVKEVLAGD 236
              |.|...:|....:.|: .|.|:::.:|.|.|.:|.|..||.|.|.|:..:|.|.:||.:.||.
 Worm   249 --ELPSEWKLDPREIEVRSFQAGDYIVKPGESDDAIYVAIDGELTVHIRHMEGKEYLVKCIPAGG 311

Human   237 SVHSLLSILDIITGHAAPYKTVSVRAAIPSTILRLPAAAFHGVFEKYPETLVRVVQIIMVRLQRV 301
            |..||||:|||:....:.::||:::||.|..:.:.|..:|...:.|.||..:|.:||::.||..|
 Worm   312 SFFSLLSMLDILMDFPSIFRTVALKAADPCRVAKFPITSFRESYHKNPEAWIRPIQIVITRLLHV 376

Human   302 TFLALHNYLGLTTELFNAESQAIPLVSVASVAAGKAKKQVFYGEEERLKKPPRLQESCDSADHGG 366
            |...||.|:||::||.....                       :::|.:.
 Worm   377 TLTTLHQYMGLSSELMRRRR-----------------------DDDRHRN--------------- 403

Human   367 GRPAAAGPLLKRSHSVPAPSIRKQILEELEKPGAGDPDPSAPQGGPGSATSDLGMACDRARVFLH 431
                                                          ||:||.|.:
 Worm   404 ----------------------------------------------GSSTSKLQL---------- 412

Human   432 SDEHPGSSVASKSRKSVMVAEIPSTVSQHSESHTDETLASRKSDA-IFRAAKKDLLTLMKLEDSS 495
                   |::.|.:      |.|..::.:.:   |:.:.:||..| .|.....|::       |.
 Worm   413 -------SLSLKKK------EKPFNINDNEQ---DQLIVARKWMAEAFGLVADDVV-------SE 454

Human   496 LLDGRVALLHVPAGTVVSRQGDQDASILFVVSGLL----------------HVYQRKIGSQEDTC 544
            .:..::.|....||.|:..||.::..::.|:.|.|                .::..:...::::.
 Worm   455 QIGSKIHLESYEAGHVIIEQGAEEEVLMMVLHGNLILAQYGSDFFAQIERESLFDEENNEEDESA 519

Human   545 LFLTRPGEMVGQLAVLTGEPLIFTVKANRDCSFLSISKAHFYEIMRKQPTVVLGVAHTVVKRMSS 609
            :......|:||.|.:||.||..:|::|........:.|..|...:...|.:.|.|||:|::|:|.
 Worm   520 VIRVTARELVGGLQILTNEPSFYTIRAAVQTRVAIMKKKDFSAFLEAHPEIYLPVAHSVLRRLSP 584

Human   610 FVRQIDFALDWVEVEAGRAIYRQGDKSDCTYIMLSGRLRSVIRKDDGKKRLAGEYGRGDLVGVVE 674
            |:|.:|||||||.|::|.|.||.||.:|..:::||||||||     .||.:..|:||||::|::|
 Worm   585 FLRGVDFALDWVLVDSGHACYRAGDMADSLFVVLSGRLRSV-----EKKTVVEEFGRGDVLGMME 644

Human   675 TLTHQARATTVHAVRDSELAKLPAGALTSIKRRYPQVVTRLIHLLGEKILGSLQQGPVTGHQLGL 739
            .||.:.|||||.|||.|:||::|.|.|..||.:||||..||:.|||:....:.::.|.....:..
 Worm   645 VLTKKPRATTVLAVRFSQLARVPEGLLNFIKMQYPQVGFRLVQLLGQYYSQTNRRAPFAAPTVIR 709

Human   740 PTEGSKWDLGNPAVNLSTVAVMPVSEEVPLTAFALELEHALSAIGPTLLLTSDNIKRRLGSAALD 804
            ..|....|..:...||.|:||:|.|.:|||..|..||.||||:....|.|:|..:...|..:.|:
 Worm   710 TNELGATDPMSHIKNLHTIAVVPASPDVPLVPFTCELYHALSSNLRVLRLSSQKVAACLDPSVLE 774

Human   805 SVHEYRLSSWLGQQEDTHRIVLYQADGTLTPWTQRCVRQADCILIVGLGDQEPTVGELERML--- 866
            ...::||..||..||||:.:|:|:.|.|.|.||:||:||||.||:|.:|.:.|....|.|.|
 Worm   775 KQADFRLMHWLNVQEDTYPLVIYECDFTQTNWTRRCLRQADAILVVAIGGKTPEKQTLMRELMNM 839

Human   867 ESTAVRAQKQLILLHREEGPAPARTVEWLNMRSWCSGHLHLCCPRRVFS-RRSLPKL-------- 922
            ....||..|:||||..|....|:.|:|||. .|:.|||.|:..|:|:.. .|...|:
 Worm   840 NQDGVRTNKELILLWPESTKTPSGTIEWLK-NSYFSGHHHIRAPKRMLQWNRKFRKMSRAEVMTP 903

Human   923 -------VEMY-KHVFQRPPDRHSDFSRLARVLTGNAIALVLGGGGARGCAQVGVLKALAECGIP 979
                   :|.| |:||. .|||.||||||||:||||||.||||||||||.|.||||:||.|.|||
 Worm   904 TSVENEVIEYYEKNVFW-TPDRRSDFSRLARILTGNAIGLVLGGGGARGAAHVGVLRALREEGIP 967

Human   980 VDMVGGTSIGAFVGALYSEERNYSQMRIRAKQWAEPAGRVEAFCKFHMWPQGMTSLMKAALDLTY 1044
            ||:|||||||:.:|.||:|..:...:..||..|.                .||:||.:..|||||
 Worm   968 VDIVGGTSIGSLIGGLYAETPDDVVVETRAASWF----------------NGMSSLWRKLLDLTY 1016

Human  1045 PITSMFSGAGFNSSIFSVFKDQQIEDLWIPYFAITTDITASAMRVHTDGSLWWYVRASMSLSGYM 1109
            ..::||:||.||.||..:|:::.||||||.||.|:|||:.|.||||..|.||.|.||||||:||:
 Worm  1017 AHSAMFTGAQFNFSIKDLFEERLIEDLWISYFCISTDISTSEMRVHRSGPLWAYCRASMSLAGYL 1081

Human  1110 PPLCDPKDGHLLMDGGYINNLPADVARSMGAKVVIAIDVGSRDETDLTNYGDALSGWWLLWKRWN 1174
            ||||||:|||||:||||:||:||||.|::||:.|||.||||.:||:|.:|||:|||.|:|.||.|
 Worm  1082 PPLCDPQDGHLLLDGGYVNNVPADVMRNLGARCVIACDVGSIEETNLYDYGDSLSGMWVLLKRLN 1146

Human  1175 PLATKVKVLNMAEIQTRLAYVCCVRQLEVVKSSDYCEYLRPPIDSYSTLDFGKFNEICEVGYQHG 1239
            |..|..::|||.|||:|||||.|||||||||.:.||.||||||:.:.||||.||.||.|:|.::|
 Worm  1147 PFGTPPRILNMEEIQSRLAYVSCVRQLEVVKKASYCRYLRPPIEPFKTLDFPKFQEIMELGLKYG 1211

Human  1240 RTVF------DIWGRSGVL--EKMLRD---QQGPSKKP--ASAVLTCPNASFTDLAEIVSRIEPA 1291
            |...      |   |:|:|  ||..|.   ||...:||  :.||      ||||||..:|:|...
 Worm  1212 REACHELITND---RAGILGDEKETRKFKRQQSRREKPDVSRAV------SFTDLAAAMSKIPVV 1267

Human  1292 KPA----------------------MVDDESDYQTEYEEELLDVPRDAYADFQSTSAQQGSD--L 1332
            :|.                      ::||:....|:|.||            :|:.::.|::  .
 Worm  1268 RPTLRHSMSLNPSANGPVGRAGDHFLLDDDLFNDTDYYEE------------ESSQSENGNESFT 1320

Human  1333 EDE 1335
            |||
 Worm  1321 EDE 1323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNPLA7	XP_047279320.1	CAP_ED	170..291	CDD:237999	42/121 (35%)
		CAP_ED	485..593	CDD:237999	22/123 (18%)
		CAP_ED	608..716	CDD:237999	58/107 (54%)
		Pat_PNPLA6_PNPLA7	937..1258	CDD:132864	191/328 (58%)
ZK370.4	NP_498927.2	CAP_ED	261..364	CDD:237999	37/102 (36%)
		CAP_ED	449..570	CDD:237999	24/127 (19%)
		CAP_ED	578..686	CDD:237999	60/112 (54%)
		Patatin_and_cPLA2	926..1212	CDD:416256	183/301 (61%)