DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nsr and QKI

DIOPT Version :9

Sequence 1:	NP_001286736.1	Gene:	nsr / 37577	FlyBaseID:	FBgn0034740	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_006766.1	Gene:	QKI / 9444	HGNCID:	21100	Length:	341	Species:	Homo sapiens

Alignment Length:	353	Identity:	87/353 - (24%)
Similarity:	149/353 - (42%)	Gaps:	92/353 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EEQNQDQPTQDQPTYQPRLNEVAQKFLADLDEERKRLSAEFPLCAL------LIDESVDRVFSTG 67
            |.:.:.:||.|              :|..|..::|.:|:....|.:      |:||.:.||
Human     6 ETKEKPKPTPD--------------YLMQLMNDKKLMSSLPNFCGIFNHLERLLDEEISRV---- 52

  Fly    68 RIPGKEFYADVYH--------QRP------MKITQKVFVPVNKFPKFNFARKILGPKGNSVRRLK 118
               .|:.|.|..:        :.|      :::.:|::|||.::|.|||..:||||:|.:.::|:
Human    53 ---RKDMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLE 114

  Fly   119 EETNCKIVIKGRSSMRDRNKEEELRSSGDPRYAHLHKDLFLEVSAVAPPAECYARIAYALAEIRK 183
            .||.|||:::|:.||||:.|||:.|  |.|.:.||::||.:.::..........::..|:.|::|
Human   115 AETGCKIMVRGKGSMRDKKKEEQNR--GKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKK 177

  Fly   184 YLIP--DDNDDVWHEQQRELMEMN---PESAKKSNGLNMA-------------------PYRSIF 224
            .|:|  :..|.:...|..||..:|   .::..||..|..:                   |..::.
Human   178 LLVPAAEGEDSLKKMQLMELAILNGTYRDANIKSPALAFSLAATAQAAPRIITGPAPVLPPAALR 242

  Fly   225 DKTIGGNR--------------NGAPKYNNQIRRVTENPREVADMEEVEYDYDEHRMPPSRPSLG 275
            ..|..|..              ||.|.....|  |...|.  |.:....|:| .:.:.|:...|
Human   243 TPTPAGPTIMPLIRQIQTAVMPNGTPHPTAAI--VPPGPE--AGLIYTPYEY-PYTLAPATSIL- 301

  Fly   276 FEYSKPPPSMTATNATPFK----RAYPY 299
             ||...|..:....||..:    |.:||
Human   302 -EYPIEPSGVLGAVATKVRRHDMRVHPY 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nsr	NP_001286736.1	SF1_like-KH	87..206	CDD:239088	44/123 (36%)
QKI	NP_006766.1	STAR_dimer	10..66	CDD:406848	16/76 (21%)
		Qua1 domain, involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:Q17339	11..82		17/91 (19%)
		KH-I_Hqk	81..183	CDD:411893	39/103 (38%)
		Qua2 domain, involved in RNA binding. /evidence=ECO:0000269\|PubMed:23630077	182..213		7/30 (23%)
		PHA03247	<211..314	CDD:223021	19/109 (17%)
		SH3-binding	276..279		0/2 (0%)
		Quaking_NLS	312..341	CDD:406855	5/17 (29%)
		Nuclear localization signal. /evidence=ECO:0000250	324..330		3/5 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155041
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740