DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment nsr and Khdrbs1

DIOPT Version :9

Sequence 1:	NP_001286736.1	Gene:	nsr / 37577	FlyBaseID:	FBgn0034740	Length:	340	Species:	Drosophila melanogaster
Sequence 2:	NP_035447.3	Gene:	Khdrbs1 / 20218	MGIID:	893579	Length:	443	Species:	Mus musculus

Alignment Length:	356	Identity:	106/356 - (29%)
Similarity:	161/356 - (45%)	Gaps:	80/356 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 EVAQKFLADLDEERKRLSAEFPLCALLIDESVDRV-FSTGRIPGKEFYADVYHQRPMKITQKVFV 92
            |...|:|.:|..|:..|...|.....|:...:::: ....:...:|.|.|::..:.||:.::|.:
Mouse    98 EPENKYLPELMAEKDSLDPSFTHAMQLLSVEIEKIQKGESKKDDEENYLDLFSHKNMKLKERVLI 162

  Fly    93 PVNKFPKFNFARKILGPKGNSVRRLKEETNCKIVIKGRSSMRDRNKEEELRSSGDPRYAHLHKDL 157
            ||.::|||||..|||||:||:::||:|||..||.:.|:.||||:.||||||..|||:||||:.||
Mouse   163 PVKQYPKFNFVGKILGPQGNTIKRLQEETGAKISVLGKGSMRDKAKEEELRKGGDPKYAHLNMDL 227

  Fly   158 FLEVSAVAPPAECYARIAYALAEIRKYLIPDDNDDVWHEQQRELMEMN--PESAKKSNGLNM--- 217
            .:.:....||.|.||.:|:|:.|::|:|:||..||:..||..||..:|  ||.: :..|:::
Mouse   228 HVFIEVFGPPCEAYALMAHAMEEVKKFLVPDMMDDICQEQFLELSYLNGVPEPS-RGRGVSVRGR 291

  Fly   218 -------------------------APYRSIFDKTIGGNR--------NGAPKYNNQ---IRRV- 245
                                     .|.|....:.....|        .|||....:   |:|:
Mouse   292 GAAPPPPPVPRGRGVGPPRGALVRGTPVRGSITRGATVTRGVPPPPTVRGAPTPRARTAGIQRIP 356

  Fly   246 ---TENPREVADM-----------------------EEVEYDYDEHRMPPSRPSLG-FEYSKPPP 283
               |..|....|.                       |...|||....:..|..:.| .:::...|
Mouse   357 LPPTPAPETYEDYGYDDTYAEQSYEGYEGYYSQSQGESEYYDYGHGELQDSYEAYGQDDWNGTRP 421

  Fly   284 SMTATNATPFKRAYPYPTDMNRTREPPIKSY 314
            |:.|..|.|.|.||         ||.|...|
Mouse   422 SLKAPPARPVKGAY---------REHPYGRY 443

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
nsr	NP_001286736.1	SF1_like-KH	87..206	CDD:239088	61/120 (51%)
Khdrbs1	NP_035447.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..94
		Involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:Q07666	100..260		66/159 (42%)
		Qua1	103..153	CDD:318503	9/49 (18%)
		SF1_like-KH	157..276	CDD:239088	60/118 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..317		1/37 (3%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..345		4/18 (22%)
		Interaction with HNRNPA1. /evidence=ECO:0000250\|UniProtKB:Q07666	351..443		22/100 (22%)
		Sam68-YY	366..415	CDD:318716	7/48 (15%)
		Interaction with ZBTB7A. /evidence=ECO:0000250\|UniProtKB:Q07666	400..420		2/19 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..443		12/40 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167845528
Domainoid	1	1.000	56	1.000	Domainoid score	I10944
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	186	1.000	Inparanoid score	I3911
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012406at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8696
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.860