DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3927 and QKI

DIOPT Version :9

Sequence 1:	NP_611681.1	Gene:	CG3927 / 37576	FlyBaseID:	FBgn0034739	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_006766.1	Gene:	QKI / 9444	HGNCID:	21100	Length:	341	Species:	Homo sapiens

Alignment Length:	214	Identity:	63/214 - (29%)
Similarity:	109/214 - (50%)	Gaps:	38/214 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 EKQNQDQPTYQPRLNEVAQKFLADLDAERKRLSAEFPLCAL------LIDESVDRVYSTGRIPGK 67
            |.:.:::|...|       .:|..|..::|.:|:....|.:      |:||.:.||       .|
Human     4 EMETKEKPKPTP-------DYLMQLMNDKKLMSSLPNFCGIFNHLERLLDEEISRV-------RK 54

  Fly    68 EPFADVYQQKPMK-----------IIQ---KVFVPVNKFPKFNFTGKILGPKGNSLRRLQEETHC 118
            :.:.|.......|           |:|   |::|||.::|.|||.|:||||:|.:.::|:.||.|
Human    55 DMYNDTLNGSTEKRSAELPDAVGPIVQLQEKLYVPVKEYPDFNFVGRILGPRGLTAKQLEAETGC 119

  Fly   119 KIVIKGRNSMRDRNKEEELRSSGDPRYAHLHKDLFLEVSAVAPPAECYARIAYALAEIRKYLIP- 182
            ||:::|:.||||:.|||:.|  |.|.:.||::||.:.::..........::..|:.|::|.|:|
Human   120 KIMVRGKGSMRDKKKEEQNR--GKPNWEHLNEDLHVLITVEDAQNRAEIKLKRAVEEVKKLLVPA 182

  Fly   183 -DDNDDVWHEQQRELMEMN 200
             :..|.:...|..||..:|
Human   183 AEGEDSLKKMQLMELAILN 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3927	NP_611681.1	SF1_like-KH	83..201	CDD:239088	46/123 (37%)
QKI	NP_006766.1	STAR_dimer	10..66	CDD:406848	14/69 (20%)
		Qua1 domain, involved in homodimerization. /evidence=ECO:0000250\|UniProtKB:Q17339	11..82		16/84 (19%)
		KH-I_Hqk	81..183	CDD:411893	41/103 (40%)
		Qua2 domain, involved in RNA binding. /evidence=ECO:0000269\|PubMed:23630077	182..213		5/20 (25%)
		PHA03247	<211..314	CDD:223021
		SH3-binding	276..279
		Quaking_NLS	312..341	CDD:406855
		Nuclear localization signal. /evidence=ECO:0000250	324..330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155042
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740