DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3927 and SF1

DIOPT Version :9

Sequence 1:	NP_611681.1	Gene:	CG3927 / 37576	FlyBaseID:	FBgn0034739	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_001365886.1	Gene:	SF1 / 7536	HGNCID:	12950	Length:	764	Species:	Homo sapiens

Alignment Length:	232	Identity:	57/232 - (24%)
Similarity:	106/232 - (45%)	Gaps:	43/232 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PSELTEKQNQDQPTYQ---PRLNEVAQKFLADLDAERKRLSAEFPLCALLIDESVDRVYSTGRIP 65
            |....::....:|.|.   .|||....:....|:.||..|..|  :.||              .|
Human   198 PPNPEDRSPSPEPIYNSEGKRLNTREFRTRKKLEEERHNLITE--MVAL--------------NP 246

  Fly    66 GKEPFADVYQQKPMKIIQKVFVPVNKFPKFNFTGKILGPKGNSLRRLQEETHCKIVIKGRNSMRD 130
            ..:|.|| |:....::..||.:|.:::|:.||.|.::||:||:|:.:::|.:.||:|:|:.|:::
Human   247 DFKPPAD-YKPPATRVSDKVMIPQDEYPEINFVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKE 310

  Fly   131 ----RNKEEELRSSGDPRYAHLHKDLFLEVSAVAPPAECYARIAYALAEIRKYL-----IPDDND 186
                |...:.|....:|.:|.:             .|.....:..|:.:||..|     .|:|.:
Human   311 GKVGRKDGQMLPGEDEPLHALV-------------TANTMENVKKAVEQIRNILKQGIETPEDQN 362

  Fly   187 DVWHEQQRELMEMNPKSAKKSNGLNMAPYRSNFDKAI 223
            |:...|.|||..:|....:..|.: :.|::|:..::|
Human   363 DLRKMQLRELARLNGTLREDDNRI-LRPWQSSETRSI 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3927	NP_611681.1	SF1_like-KH	83..201	CDD:239088	34/126 (27%)
SF1	NP_001365886.1	MSL5	142..382	CDD:227503	53/213 (25%)
SF1	NP_001365886.1	ZnF_C2HC	403..418	CDD:197667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.731683	Normalized mean entropy	S1317
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.760