DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3927 and KHDRBS3

DIOPT Version :9

Sequence 1:	NP_611681.1	Gene:	CG3927 / 37576	FlyBaseID:	FBgn0034739	Length:	270	Species:	Drosophila melanogaster
Sequence 2:	NP_006549.1	Gene:	KHDRBS3 / 10656	HGNCID:	18117	Length:	346	Species:	Homo sapiens

Alignment Length:	275	Identity:	98/275 - (35%)
Similarity:	140/275 - (50%)	Gaps:	46/275 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 QKFLADLDAERKRLSAEFPLCALLIDESVDRVYSTGRIPGKEPFADVYQQKPMKIIQKVFVPVNK 91
            :|:|.:|.||:..|...|.....|:::.::: :..|....:|.:.||...|.||:.|||.:||.:
Human     3 EKYLPELMAEKDSLDPSFTHALRLVNQEIEK-FQKGEGKDEEKYIDVVINKNMKLGQKVLIPVKQ 66

  Fly    92 FPKFNFTGKILGPKGNSLRRLQEETHCKIVIKGRNSMRDRNKEEELRSSGDPRYAHLHKDLFLEV 156
            ||||||.||:|||:||||:||||||..|:.|.|:.||||:.||||||.||:.:|.||:.||.:.:
Human    67 FPKFNFVGKLLGPRGNSLKRLQEETLTKMSILGKGSMRDKAKEEELRKSGEAKYFHLNDDLHVLI 131

  Fly   157 SAVAPPAECYARIAYALAEIRKYLIPDDNDDVWHEQQRELMEMN--------------------- 200
            ...|||||.|||:.:||.||:|:||||.||::...|.:||..:|
Human   132 EVFAPPAEAYARMGHALEEIKKFLIPDYNDEIRQAQLQELTYLNGGSENADVPVVRGKPTLRTRG 196

  Fly   201 ---PKSAKKSNGLNMAPYRSNFDKAI----GAIRNRAPKYNNQ--------------IRRVTENP 244
               |...:...|:...|......:..    |.:..|.|....:              .|.....|
Human   197 VPAPAITRGRGGVTARPVGVVVPRGTPTPRGVLSTRGPVSRGRGLLTPRARGVPPTGYRPPPPPP 261

  Fly   245 REVAYMEEVEYDYDE 259
            .:..|   .|||||:
Human   262 TQETY---GEYDYDD 273

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3927	NP_611681.1	SF1_like-KH	83..201	CDD:239088	69/141 (49%)
KHDRBS3	NP_006549.1	Involved in homodimerization. /evidence=ECO:0000269\|PubMed:26758068	1..160		78/157 (50%)
		Qua1	4..53	CDD:406639	12/49 (24%)
		KH-I_KHDRBS3	48..160	CDD:411898	67/111 (60%)
		Interaction with SIAH1. /evidence=ECO:0000269\|PubMed:15163637	212..251		4/38 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..267		7/56 (13%)
		Sam68-YY	266..320	CDD:406871	6/11 (55%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155050
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5176
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	168	1.000	Inparanoid score	I4151
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1012406at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8456
orthoMCL	1	0.900	-	-		OOG6_110428
Panther	1	1.100	-	-	O	PTHR11208
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.760