Protein Alignment dnr1 and frmd7

DIOPT Version :10

• Sequence 1: NP_001261137.1
• Gene: dnr1 / 37575
• FlyBaseID: FBgn0260866
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: XP_005173955.3
• Gene: frmd7 / 751637
• ZFINID: ZDB-GENE-060825-67
• Length: 675
• Species: Danio rerio
• Alignment Length: 519
• Identity: 90/519 - (17%)
• Similarity: 161/519 - (31%)
• Gaps: 178/519 - (34%)

  Fly    11 TQQAVKWDPKANGQECLEKVCRAMNIICEMEYFGLEHWTPNQKESQTRQWINLRNRLSGDSGSSG 75
            ::...:.:.:..|::....||..:.:: |.||||||.    :....:..|:.|...|:.......
Zfish    32 SEHVFQMEQRVLGKDFFNSVCGHLKLV-EKEYFGLEF----RHHCGSYVWLELLKPLAKQIKRRN 91

  Fly    76 SGIQLMLALRVKFWVPVHFILQESV-RNLFYMQARRDLLEGRLTAPDWSGAAKLAALLCQADGLR 139
               .|:....|||:.|....||..| |.||.:|.::||..|.||..| :.||.|.:.|.||:...
Zfish    92 ---DLIFRFIVKFFPPDPGELQREVTRYLFALQIKQDLSNGSLTCSD-NSAALLVSYLLQAEIGD 152

  Fly   140 FNESSLKADCPMRMRRELAQQQQQQQQQAQQHRLEQQRKEKEHVLSFKKRRLSKQKSMEHIEVCT 204
            |.|             ||                     :|:|:   :.:|....:.:.|.::
Zfish   153 FIE-------------EL---------------------DKQHL---ENKRYIPNQDVLHKKI-- 178

  Fly   205 LPAASTTSCSLQPSPSASASASASASASASASTSACSQTHSNSSSSSPSNSSSQTGLDERLASNP 269
                                                                             
Zfish   179 ----------------------------------------------------------------- 178

  Fly   270 LRVYEEYFMQPSCEGEPPADYLRQIAVEHGKLAKLQMSLKTAKYWLLKSIQDLEGYGEELFSGVT 334
            :|.::.:      .|:.||:                     |.:.||:..:.|:.||  :.....
Zfish   179 MRFHKRH------RGQSPAE---------------------ADHQLLEVSRKLDMYG--IRPHAA 214

  Fly   335 TNESATRCDIAVGAHGITVCRGGEK-QSIPFGAIAAAKSLRRTF--KLEYVDDHNDRKELEIKLP 396
            |:....|.::||...|:.|.:|..| .:..:..:......|:.|  ||......:.:..:|..:.
Zfish   215 TDGENMRINLAVTHCGVLVFQGNTKINTFSWANVRKLSFKRKHFLIKLHTTIVASCKDTVEFTMA 279

  Fly   397 KQPIAAGLYRSITERHAFY------------------VCDKVRGVVTNQ---FTRDLKGTIASMF 440
            .:.:....::...|.|.|:                  .|.:..|....|   ||:..:..|...|
Zfish   280 NRDVCKAFWKMCVEYHTFFRLSQEPKSKQKSLLYSRGSCFRYSGRTQKQLLDFTKKSEEKINLPF 344

  Fly   441 MENTELGKRYVFDIQHT--CREVHD---QARRTLHERGGDLVAEGAEGCSAVAGGLGASAVGEP 499
            |      ::|..|...|  ||...|   ...:..:|:.........:.|.:....|..|...:|
Zfish   345 M------RKYCKDYYDTRQCRSSPDLLTDVSKQAYEQSCGFPPPSGKRCQSAVEVLNTSEFQDP 402

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnr1	NP_001261137.1	Ubl1_cv_Nsp3_N-like	1..89	CDD:475130	16/77 (21%)
		FERM_M	91..>148	CDD:459788	22/57 (39%)
		FERM_C_MYLIP_IDOL	325..435	CDD:270016	23/133 (17%)
		RING-HC_IAPs	545..583	CDD:438173
frmd7	XP_005173955.3	FERM_F1_FRMD7	21..106	CDD:340708	18/81 (22%)
		FERM_B-lobe	114..204	CDD:271216	31/221 (14%)
		FERM_C_FARP1-like	199..319	CDD:270014	19/121 (16%)
		FA	312..>347	CDD:462582	8/40 (20%)