Protein Alignment dnr1 and Epb41l1

DIOPT Version :10

• Sequence 1: NP_001261137.1
• Gene: dnr1 / 37575
• FlyBaseID: FBgn0260866
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_067713.2
• Gene: Epb41l1 / 59317
• RGDID: 71087
• Length: 1551
• Species: Rattus norvegicus
• Alignment Length: 662
• Identity: 129/662 - (19%)
• Similarity: 207/662 - (31%)
• Gaps: 215/662 - (32%)

  Fly     3 CIVNLPNGTQQAVKWDPKANGQECLEKVCRAMNIICEMEYFGLEHWTPNQKESQTRQWINLRNRL 67
            |.|.|.:.::...:.:....||...:.||..:|:: |.:||||   |....:|| :.|::....:
  Rat    99 CRVTLLDASEYECEVEKHGRGQVLFDLVCEHLNLL-EKDYFGL---TFCDADSQ-KNWLDPSKEI 158

  Fly    68 SGDSGSSGSGIQLMLALRVKFWVPVHFILQESV-RNLFYMQARRDLLEGRLTAPDWSGAAKLAAL 131
            .....||    ....|..|||:.|....|.|.: |....:|.|.|::.|||.. .:...|.|.:.
  Rat   159 KKQIRSS----PWNFAFTVKFYPPDPAQLTEDITRYYLCLQLRADIITGRLPC-SFVTHALLGSY 218

  Fly   132 LCQAD---------------GLRF--NESSLKADCPMRMRRELAQQQQQQQQ--------QAQQH 171
            ..||:               .|||  |::           |||.::..:..:        :|:.|
  Rat   219 AVQAELGDHDTEEHVGNYVSELRFAPNQT-----------RELEERIMELHKTYRGMTPGEAEIH 272

  Fly   172 RLEQQRKEKEHVLSFKKRRLSKQKSMEHIEVCTLPAA---------------------------S 209
            .||..:|     ||.....|...|..|.|::.....|                           |
  Rat   273 FLENAKK-----LSMYGVDLHHAKDSEGIDIMLGVCANGLLIYRDRLRINRFAWPKILKISYKRS 332

  Fly   210 TTSCSLQPSP----SASASASASASASASASTSACSQTHSNSSSSSP-----------------S 253
            .....::|..    .::.........||......|.:.|:.....||                 .
  Rat   333 NFYIKIRPGEYEQFESTIGFKLPNHRSAKRLWKVCIEHHTFFRLVSPEPPPKGFLVMGSKFRYSG 397

  Fly   254 NSSSQTGLDERLASNPLRVYE-----EYFMQPSCEGEPPADYLRQIAVEHGKLAKLQMSLKTAKY 313
            .:.:||.....|...|...:|     .|.|..|.:|   |::.|..:|...
  Rat   398 RTQAQTRQASALIDRPAPFFERSSSKRYTMSRSLDG---AEFSRPASVSEN-------------- 445

  Fly   314 WLLKSIQDLEGYGEELFSGVTTNESATRCDIAVGAHGITVCRGGEKQSIPFGAIAAAKSLRR--- 375
                  .|....|::            |.|.|..        ||.:.....|.:.....::.
  Rat   446 ------HDAGPDGDK------------REDDAES--------GGRRSEAEEGEVRTPTKIKELKP 484

  Fly   376 ------TFKLEYVDDHNDRKELEIKLPKQPIAAGLYRSITERHAFYV-----CDKVRGVVTNQFT 429
                  ..|.|::|     |..::.|..|.....|.|::.|.::..:     .::.|.:.::..:
  Rat   485 EQETTPRHKQEFLD-----KPEDVLLKHQASINELKRTLKEPNSKLIHRDRDWERERRLPSSPAS 544

  Fly   430 RDLKGTIASMFMENTELGKRYVFDIQHTCREVHDQARRTLHERGGDLVAEGAEGCSA-VAGGLGA 493
            ...|||     .|.....:|    ||.|.|:              |||...|.|... ....|.|
  Rat   545 PSPKGT-----PEKASEAQR----IQDTSRQ--------------DLVPGTATGLEMFTQKSLAA 586

  Fly   494 SAVGEPG--------VSPWAMALTTGA-------GGSMAG--------KIDLAIREKEAREAAIE 535
            |..|...        ..|..:.|.|.|       |.|::|        |:|:.: :|...|.|.|
  Rat   587 SPEGSEHWVFIERVYTRPEDLGLLTVAATQRKESGSSLSGILADGRLSKVDILV-DKFKVEVATE 650

  Fly   536 RCVDTRISEAMQ 547
            ..|.||.:...|
  Rat   651 ETVRTRRTSTQQ 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnr1	NP_001261137.1	Ubl1_cv_Nsp3_N-like	1..89	CDD:475130	22/85 (26%)
		FERM_M	91..>148	CDD:459788	18/74 (24%)
		FERM_C_MYLIP_IDOL	325..435	CDD:270016	18/123 (15%)
		RING-HC_IAPs	545..583	CDD:438173	1/3 (33%)
Epb41l1	NP_067713.2	B41	98..288	CDD:214604	51/214 (24%)
		FERM_C_4_1_family	283..376	CDD:270005	11/92 (12%)
		FA	385..428	CDD:462582	6/42 (14%)
		SAB	493..>524	CDD:461285	9/35 (26%)
		4_1_CTD	1412..1537	CDD:461774