Protein Alignment dnr1 and EPB41L5

DIOPT Version :10

• Sequence 1: NP_001261137.1
• Gene: dnr1 / 37575
• FlyBaseID: FBgn0260866
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: XP_006712714.1
• Gene: EPB41L5 / 57669
• HGNCID: 19819
• Length: 740
• Species: Homo sapiens
• Alignment Length: 785
• Identity: 155/785 - (19%)
• Similarity: 260/785 - (33%)
• Gaps: 254/785 - (32%)

  Fly     3 CIVNLPNGTQQAVKWDPKANGQECLEKVCRAMNIICEMEYFGLE--------HWTPNQKESQTRQ 59
            |.|:|.:||..:|....||.|||..:::...:::| |.:||||.        ||....|..:.:.
Human    45 CRVSLLDGTDVSVDLPKKAKGQELFDQIMYHLDLI-ESDYFGLRFMDSAQVAHWLDGTKSIKKQV 108

  Fly    60 WINLRNRLSGDSGSSGSGIQLMLALRVKFW-VPVHFILQESVRNLFYMQARRDLLEGRLTAPDWS 123
            .|               |....|.|||||: ...:.:.:|..|.||.:|.::|:|.|:|..| :.
Human   109 KI---------------GSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLDCP-FD 157

  Fly   124 GAAKLAALLCQAD----GLRFNESSLKAD---CPMRMRR-ELA------QQQQQQQQQAQQHRL- 173
            .|.:|||...||:    .|..:...|.::   .|::... |||      :.:.|...||:.:.|
Human   158 TAVQLAAYNLQAELGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYRGQTPAQAETNYLN 222

  Fly   174 ----------------------------------------------------------------- 173
                                                                             
Human   223 KAKWLEMYGVDMHVVKARDGNDYSLGLTPTGVLVFEGDTKIGLFFWPKITRLDFKKNKLTLVVVE 287

  Fly   174 -EQQRKEKEHVLSFKKRRLSKQKSMEHIEVCTL----------PAASTTSCS------------- 214
             :.|.||:||...|   ||...|:.:|:..|.:          |...::..|
Human   288 DDDQGKEQEHTFVF---RLDHPKACKHLWKCAVEHHAFFRLRGPVQKSSHRSGFIRLGSRFRYSG 349

  Fly   215 ---LQPSPSASASASASASASASASTS-------ACS------QTHSNSSSSSPSNSSSQT-GLD 262
               .|.:.:..|..|.|.....|...|       ||:      ..|:|.|:.  ||.|.|. |:.
Human   350 KTEYQTTKTNKARRSTSFERRPSKRYSRRTLQMKACATKPEELSVHNNVSTQ--SNGSQQAWGMR 412

  Fly   263 ERL------ASNPLRVYEEYFMQPSCEGEPPADYLRQIAVEHG-KLAKLQMSLKTAKYWLLKSIQ 320
            ..|      :|.|:.|..|...|     .|..|       :|. |...|.:.|..:...|..:|.
Human   413 SALPVSPSISSAPVPVEIENLPQ-----SPGTD-------QHDRKCIPLNIDLLNSPDLLEATIG 465

  Fly   321 DLEGYGEELFSGVTTNESATRCDIAVGAHGITVCRGGEKQSIPFGAIAAAKSLRRTF-KLEYVDD 384
            |:.|..:.:    .|:::....::|....|:     ||.:       ...::|:.|. ||:.::.
Human   466 DVIGASDTM----ETSQALNDVNVATRLPGL-----GEPE-------VEYETLKDTSEKLKQLEM 514

  Fly   385 HND-----RKELEIKLPKQPIAAGLYRSITERHAFYVCDKVRGVVTNQFTRDLKGTIASMFMENT 444
            .|.     |..:::.:..|....    .:||:....|.:. .|:...:...|.|..|....:|..
Human   515 ENSPLLSPRSNIDVNINSQEEVV----KLTEKCLNNVIES-PGLNVMRVPPDFKSNILKAQVEAV 574

  Fly   445 ELGKRYVFDIQHTCREVHDQARRT--LHERGGDLVAEGAEGCSAVAGGLGASAVGEPGVSPWAMA 507
            ....:....:.|....|.|.|..:  |:|....|..|..|                     ..|.
Human   575 HKVTKEDSLLSHKNANVQDAATNSAVLNENNVPLPKESLE---------------------TLML 618

  Fly   508 LTTGAGGSMAGKIDLAIREKEAREAAI-ERCVDTRISEAMQCKICMDRAINTVFNPCCHVIACA- 570
            :|....||:   :..|..|.:|..|:: |..:|..::..:        :..::..|...|..|.
Human   619 ITPADSGSV---LKEATDELDALLASLTENLIDHTVAPQV--------SSTSMITPRWIVPLCVY 672

  Fly   571 ---QCAARCSNCPNCRVKITSV--------VKIYLPPELRTSQTGSGATTTSSSSIMGDGQVEEQ 624
               |..|..:....|.:.:|..        :.:..||......     ..|||..|:    .||.
Human   673 LPQQSGAMSNGLAGCEMLLTGKEGHGNKDGISLISPPAPFLVD-----AVTSSGPIL----AEEA 728

  Fly   625 LLQQQ 629
            :|:|:
Human   729 VLKQK 733

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnr1	NP_001261137.1	Ubl1_cv_Nsp3_N-like	1..89	CDD:475130	27/93 (29%)
		FERM_M	91..>148	CDD:459788	18/60 (30%)
		FERM_C_MYLIP_IDOL	325..435	CDD:270016	18/115 (16%)
		RING-HC_IAPs	545..583	CDD:438173	5/41 (12%)
EPB41L5	XP_006712714.1	FERM_F1_EPB41L5	41..126	CDD:340725	28/96 (29%)
		B41	44..235	CDD:214604	54/206 (26%)
		FERM_C_NBL4_NBL5	231..324	CDD:270007	11/95 (12%)
		FA	337..378	CDD:462582	6/40 (15%)