Protein Alignment dnr1 and frmd5a

DIOPT Version :10

• Sequence 1: NP_001261137.1
• Gene: dnr1 / 37575
• FlyBaseID: FBgn0260866
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: XP_699526.3
• Gene: frmd5a / 570903
• ZFINID: ZDB-GENE-050419-226
• Length: 576
• Species: Danio rerio
• Alignment Length: 686
• Identity: 128/686 - (18%)
• Similarity: 213/686 - (31%)
• Gaps: 243/686 - (35%)

  Fly     3 CIVNLPNGTQQAVKWDPKANGQECLEKVCRAMNIICEMEYFGLEHWTPNQKESQTRQWINLRNRL 67
            |.|.|.:.|:........|.||...:.:|..:|:: |.:|||:.:..|:::    |.|:.....:
Zfish    20 CTVRLLDDTEYTCTIQRDAKGQYLFDLICHHLNLL-EKDYFGIRYVDPDKQ----RHWLEFTKSI 79

  Fly    68 SGDSGSSGSGIQLMLALRVKFWVPVHFILQESV-RNLFYMQARRDLLEGRLTAPDWSGAAKLAAL 131
            |....|..   ...:.|||||:.|....|:|.: |.|.::|.:|||..|||.... |.||.|||.
Zfish    80 SKQMKSQP---PFTMCLRVKFYPPDPAALKEEITRYLVFLQIKRDLYHGRLLCKT-SDAAMLAAY 140

  Fly   132 LCQADGLRFNESSLKADCPMRMRRELAQQQQQQQQQAQQHRLEQQRKEKEHVLSFKKRRLSKQKS 196
            :.||                    |:......:..:....:.:...|..|.:    :||:::...
Zfish   141 ILQA--------------------EIGDYDPGKHPEGYSSKFQFFPKHSEKL----ERRIAEIHK 181

  Fly   197 MEHIEVCTLPAASTTSCSLQPSPSASASASASASASASASTSACSQTHSNSSSSSPSNSSSQTGL 261
            .|.|
Zfish   182 TELI------------------------------------------------------------- 185

  Fly   262 DERLASNPLRVYEEYFMQPSCEGEPPADYLRQIAVEHGKLAKLQMSLKTAKYWLLKSIQDLEGYG 326
                                  |:.|                     :|::...|:..|.||.||
Zfish   186 ----------------------GQTP---------------------ETSELKFLQKAQMLETYG 207

  Fly   327 EELFSGVTTNESATRCDIAVGAHGITVCRGGEK-QSIPFGAIAAAKSLRRTFKLEYVDDHNDRKE 390
            .:  .....:.|.....:|....|..|.:|.:: ..:.:..:...|...:||.: |.:...|:|.
Zfish   208 VD--PHPCKDVSGNPAFLAFTPFGFVVLQGNKRVHFLKWNEVTKLKFEGKTFHI-YANQKEDKKI 269

  Fly   391 LEIKLPKQPIAA-GLYRSITERHAFYVCDK---VRGVVTNQFTRDLKGTIASMFMENTELGKRYV 451
            :.......|.|. .|::...|..|||..:|   ||.|           :.:::|.:    |.|:.
Zfish   270 ILTYFAPTPEACKHLWKCGVENQAFYKLEKSSQVRTV-----------SSSNLFFK----GSRFR 319

  Fly   452 FDIQHTCREVHDQARRTLHE-----RGGDLVAEGAEGCSAVAGGLGASAVGEPGVSPWAMALTTG 511
            :. ....:||.:|:.:...|     |.| ||.  :..|.::..|...|:|
Zfish   320 YS-GRVAKEVMEQSAKIKREPPEIHRAG-LVP--SRSCPSITHGPRLSSV--------------- 365

  Fly   512 AGGSMAGKIDLAIREKEAREAAIERCVDTRISEAMQCKICMDRAINTVFNPCCHVIACAQCAARC 576
                               .....|.|...|.|.::.  ..|.|.:|......|..:
Zfish   366 -------------------PRTRRRAVHISIMEGLES--LRDSAHSTPVRSVSHGDS-------- 401

  Fly   577 SNCPNCRVKITSVVKIYLPPELRTSQTGSGATT--------TSSSSIMGDGQVEEQLLQQQLDEI 633
                             ..|..|:..|.||..|        :.|.|::.....|..|......:|
Zfish   402 -----------------FMPRSRSQMTDSGDRTAIISDESYSPSDSVLPTPVAEHSLELAVSRQI 449

  Fly   634 SAAPASLEAGADAGVG---VGGMAVGAGAGAGATGP 666
            :.||.|:|...::..|   ||.:| ..||.:.|.||
Zfish   450 NGAPCSIEEEKESEAGTPSVGDVA-EFGADSRAAGP 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnr1	NP_001261137.1	Ubl1_cv_Nsp3_N-like	1..89	CDD:475130	22/85 (26%)
		FERM_M	91..>148	CDD:459788	20/57 (35%)
		FERM_C_MYLIP_IDOL	325..435	CDD:270016	24/114 (21%)
		RING-HC_IAPs	545..583	CDD:438173	4/37 (11%)
frmd5a	XP_699526.3	B41	19..211	CDD:214604	59/329 (18%)
		PH-like	192..296	CDD:473070	23/106 (22%)
		FA	310..355	CDD:462582	12/52 (23%)