DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment dnr1 and birc2

DIOPT Version :9

Sequence 1:	NP_001261137.1	Gene:	dnr1 / 37575	FlyBaseID:	FBgn0260866	Length:	696	Species:	Drosophila melanogaster
Sequence 2:	XP_005161213.1	Gene:	birc2 / 373107	ZFINID:	ZDB-GENE-030825-6	Length:	647	Species:	Danio rerio

Alignment Length:	346	Identity:	74/346 - (21%)
Similarity:	137/346 - (39%)	Gaps:	68/346 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 NPLRVYEEYFMQPSCE---GEPPADYLRQIAVEHGKLAK--LQMSLKTAKYWLLKSIQDLEGYGE 327
            :|...:.::|  |.||   .|...:::.||.....:|.:  |......::.::...:..| |.||
Zfish   350 DPWVEHAKWF--PRCEYLLQEKGQEFVHQIQARFPRLFEQLLTNGDSNSREFVDPPVVHL-GPGE 411

  Fly   328 ELF-SGVTTNESATRCDIAVGAHGITVCRGGEKQSIPFGAIAAAKSLRRTFKL--EYVDDHNDRK 389
            :.. ..|..|....:..:.:|..     ||..||::....:.:.::.:...:|  :.:...::::
Zfish   412 DRSEDAVMMNNPVVKSALEMGFE-----RGLVKQTVQSKILTSGENYKTVQELVSDLLSAEDEKR 471

  Fly   390 ELEIKLPKQPIAAGLYRSITERHAFYVCDKVRGVVTNQFTRDLKGTIASMFMENTELGKRYVFDI 454
            |.|.:|..:.:|:..:..:.:.||          ..:|..:.::..:..:..||....|.|  |.
Zfish   472 EEERELLAEEMASDGFTFLKKHHA----------ALSQRLKSVQSLMDHLLEENVISQKEY--DS 524

  Fly   455 QHTCREVHDQARRTLHERGGDLVAEGAEGCSAVAGGLGASAVGEPGVSPW-----------AMAL 508
            ...|..|..|..:.:     |||         ::.|..|:.|    ...|           .||.
Zfish   525 IRNCTSVKQQTGQLI-----DLV---------LSKGNAAAEV----FRNWIKKNDVYLLRELMAQ 571

  Fly   509 TTGAGGSMAGKIDLAIREKEAREAAIERCVDTRISEAMQCKICMDRAINTVFNPCCHVIACAQCA 573
            |..|........||.: |::.|          |:.|...||:|||:.:|.||.||.|::.|.:||
Zfish   572 TNEAASPSQDLSDLPM-EEQLR----------RLQEERTCKVCMDKEVNIVFIPCGHLVVCKECA 625

  Fly   574 ARCSNCPNCRVKITSVVKIYL 594
            .....||.||..:...|:.:|
Zfish   626 PSLRKCPICRGMVKGTVRTFL 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
dnr1	NP_001261137.1	B41	3..>143	CDD:214604
		FERM_N	5..67	CDD:286467
		FERM_M	93..>143	CDD:278785
		FERM_C_MYLIP_IDOL	325..435	CDD:270016	17/112 (15%)
		zf-C3HC4_3	544..589	CDD:290631	19/44 (43%)
birc2	XP_005161213.1	BIR	51..117	CDD:237989
		BIR	206..274	CDD:197595
		BIR	299..366	CDD:237989	5/17 (29%)
		UBA_BIRC2_3	420..466	CDD:270577	7/50 (14%)
		CARD_BIRC2_BIRC3	482..573	CDD:260038	21/120 (18%)
		zf-C3HC4_3	596..641	CDD:290631	19/44 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1340284at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920