Protein Alignment dnr1 and Frmd5

DIOPT Version :10

• Sequence 1: NP_001261137.1
• Gene: dnr1 / 37575
• FlyBaseID: FBgn0260866
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: XP_038962754.1
• Gene: Frmd5 / 311362
• RGDID: 1561554
• Length: 599
• Species: Rattus norvegicus
• Alignment Length: 669
• Identity: 131/669 - (19%)
• Similarity: 217/669 - (32%)
• Gaps: 210/669 - (31%)

  Fly     3 CIVNLPNGTQQAVKWDPKANGQECLEKVCRAMNIICEMEYFGLEHWTPNQKESQTRQWINLRNRL 67
            |.|.|.:.::........|.||...:.:|..:|:: |.:|||:....|:::    |.|:.....:
  Rat    19 CTVRLLDDSEYTCTIQRDAKGQYLFDLLCHHLNLL-EKDYFGIRFVDPDKQ----RHWLEFTKSV 78

  Fly    68 SGDSGSSGSGIQLMLALRVKFWVPVHFILQESV-RNLFYMQARRDLLEGRLTAPDWSGAAKLAAL 131
            .....|..   ...:..||||:......|:|.: |.|.::|.:|||..|||.... |.||.|||.
  Rat    79 VKQLRSQP---PFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKT-SDAALLAAY 139

  Fly   132 LCQADGLRFNESSLKADCPMRMRRELAQQQQQQQQQAQQHRLE----QQRKEKEHVLSFKKRRLS 192
            :.||                    |:......:..:....:.:    ...|.::.:....|..||
  Rat   140 ILQA--------------------EIGDYDPGKHPEGYSSKFQFFPKHSEKLEKKIAEIHKTELS 184

  Fly   193 KQKSMEHIEVCTLPAAST-TSCSLQPSPSASASASASASASASASTSACSQTHSNSSSSSPSNSS 256
            .|..... |:..|..|.| .:..:.|.|....|.:|:.
  Rat   185 GQTPATS-ELNFLRKAQTLETYGVDPHPCKDVSGNAAF--------------------------- 221

  Fly   257 SQTGLDERLASNPLRVYEEYFMQPSCEGEPPADYLRQIAVEHGKLAKLQMSLKTAKYWLLKSIQD 321
                    ||..|       |.....:|.....:::.|         |..|...|.:|
  Rat   222 --------LAFTP-------FGFVVLQGNKRVHFIKCI---------LFASFTAAIHW------- 255

  Fly   322 LEGYGEELFSGVTTNESATRCDIAVGAHGITVCRGGEKQSIPFGAIAAAKSLRRTFKLEYVDDHN 386
              ..|.:.||.:|                        .:.:.:..:...|...:||.| ||....
  Rat   256 --AGGFKDFSTIT------------------------PKPLSWNEVTKLKFEGKTFYL-YVSQKE 293

  Fly   387 DRKELEIKLPKQPIAA-GLYRSITERHAFYVCDKVRGVVT----NQFTRDLK----GTIASMFME 442
            ::|.:.......|.|. .|::...|..|||..:|...|.|    |.|.:..:    |.:|...||
  Rat   294 EKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVSSSNLFFKGSRFRYSGRVAKEVME 358

  Fly   443 NTELGKRYVFDI-------QHTC---------REVHDQARRTLHERGGDLVAEGAEGC--SAVAG 489
            ::...||...:|       ..:|         ..|....||.:|..    :.||.|..  ||.:.
  Rat   359 SSAKIKREPPEIHRAGMVPSRSCPSITHGPRLSSVPRTRRRAVHIS----IMEGLESLRDSAHST 419

  Fly   490 GLGASAVGE---PGVSPWAMALTTGAGGSMAGKID-LAIREKEAREAAIERCVDTRISEAMQCKI 550
            .:.:|:.|:   |.|.           .|.|...: :|:...||...| :..:.|.::|.....:
  Rat   420 PVRSSSHGDTFLPHVR-----------SSRADSNERVAVIADEAYSPA-DSVLPTPVAEHSLELM 472

  Fly   551 CMDRAINTVFNPCCHVIACAQCAARCSNCPNCRVKITSVVKIYLPPELRTSQTGSGATTTSSSSI 615
            .:.|.||               .|.||                 ..|.:.|:| |..|:|.:.::
  Rat   473 LLSRQIN---------------GATCS-----------------IEEEKESET-STPTSTEAEAL 504

  Fly   616 MGD---------GQVEEQL 625
            .|:         |..:||:
  Rat   505 GGELRALCQGHGGSEQEQV 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnr1	NP_001261137.1	Ubl1_cv_Nsp3_N-like	1..89	CDD:475130	19/85 (22%)
		FERM_M	91..>148	CDD:459788	19/57 (33%)
		FERM_C_MYLIP_IDOL	325..435	CDD:270016	23/118 (19%)
		RING-HC_IAPs	545..583	CDD:438173	6/37 (16%)
Frmd5	XP_038962754.1	B41	19..210	CDD:214604	49/220 (22%)
		PH-like	191..324	CDD:473070	35/218 (16%)
		FA	338..383	CDD:462582	10/44 (23%)