Protein Alignment dnr1 and MYLIP

DIOPT Version :9

• Sequence 1: NP_001261137.1
• Gene: dnr1 / 37575
• FlyBaseID: FBgn0260866
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_037394.2
• Gene: MYLIP / 29116
• HGNCID: 21155
• Length: 445
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 164/601 - (27%)
• Similarity: 248/601 - (41%)
• Gaps: 173/601 - (28%)

  Fly     1 MWCIVNLPNGTQQAVKWDPKANGQECLEKVCRAMNIICEMEYFGLEHWTPNQKESQTRQWINLRN 65
            |.|.|..|:.....|:.:.||||::||.:|||.:.|| |::||||: :|.::.||   .|:||||
Human     1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGII-EVDYFGLQ-FTGSKGES---LWLNLRN 60

  Fly    66 RLSGDSGSSGSGI-QLMLALRVKFWVPVHFILQESVRNLFYMQARRDLLEGR-LTAPDWSGAAKL 128
            |:|    ....|: ...|.|||||:|..|.||||..|::|::..:..||.|. |.:|:  .|.:|
Human    61 RIS----QQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKEALLAGHLLCSPE--QAVEL 119

  Fly   129 AALLCQADGLRFNESSLKADCPMRMRRELAQQQQQQQQQAQQHRLEQQRKEKEHVLSFKKRRLSK 193
            :|||.|.....:|:::.|.:
Human   120 SALLAQTKFGDYNQNTAKYN--------------------------------------------- 139

  Fly   194 QKSMEHIEVCTLPAASTTSCSLQPSPSASASASASASASASASTSACSQTHSNSSSSSPSNSSSQ 258
                                                                             
Human   140 ----------------------------------------------------------------- 139

  Fly   259 TGLDERLASNPLRVYEEYFMQPSCEGEPPADYLRQIAVEHGKLAKLQMSLKTAKYWLLKSIQDLE 323
                          |||.     |..|..:..|..|..:|.:|.  ..|..:|:|.:|:.:..:|
Human   140 --------------YEEL-----CAKELSSATLNSIVAKHKELE--GTSQASAEYQVLQIVSAME 183

  Fly   324 GYGEELFSGVTTNESATRCDIAVGAHGITVCRG--GEKQSIPFGAIAAAKSLRRTFKLEYVDDHN 386
            .||.|..|  ..:....:..|.||..||::|:.  .....|.:..:..|....:...|....:..
Human   184 NYGIEWHS--VRDSEGQKLLIGVGPEGISICKDDFSPINRIAYPVVQMATQSGKNVYLTVTKESG 246

  Fly   387 DRKELEIKLPKQPIAAGLYRSITERHAFYVCDKVRGVVTNQFTRDLKGTIASMFM-ENTELGKRY 450
            :...|..|:.....|:||||:|||.||||.||.|...|..|::|||||.:||:|: ||..|||:|
Human   247 NSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINLGKKY 311

  Fly   451 VFDIQHTCREVHDQARRTLHERG-GDLVAEGAEGCSAVAGGLGASAVGEPGVSPWAMALTTGAGG 514
            ||||:.|.:||:|.|||.|:..| .|||:...:               .|..||...:.::....
Human   312 VFDIKRTSKEVYDHARRALYNAGVVDLVSRNNQ---------------SPSHSPLKSSESSMNCS 361

  Fly   515 SMAGKIDLAIREKEAREAAIERCVDTRISEAMQCKICMDRAINTVFNPCCHVIACAQCAARCSNC 579
            |..|   |:.::....:..:.     ::.|||.|.:|.:..||:.|.||.|.:.|..|||:..:|
Human   362 SCEG---LSCQQTRVLQEKLR-----KLKEAMLCMVCCEEEINSTFCPCGHTVCCESCAAQLQSC 418

  Fly   580 PNCRVKITSVVKIYLP 595
            |.||.::..|..:|||
Human   419 PVCRSRVEHVQHVYLP 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnr1	NP_001261137.1	B41	3..>143	CDD:214604	57/141 (40%)
		FERM_N	5..67	CDD:286467	27/61 (44%)
		FERM_M	93..>143	CDD:278785	19/50 (38%)
		FERM_C_MYLIP_IDOL	325..435	CDD:270016	36/111 (32%)
		zf-C3HC4_3	544..589	CDD:290631	19/44 (43%)
MYLIP	NP_037394.2	B41	5..190	CDD:214604	74/326 (23%)
		FERM_C_MYLIP_IDOL	185..295	CDD:270016	36/111 (32%)
		RING-HC_MYLIP	386..423	CDD:319437	15/36 (42%)
		RING-HC finger (C3HC4-type)	387..421	CDD:319437	14/33 (42%)
		Critical for homodimerization	431..433		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151922
Domainoid	1	1.000	54	1.000	Domainoid score	I11261
eggNOG	1	0.900	-	-		E1_28NMI
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8309
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7064
OMA	1	1.010	-	-		QHG50100
OrthoDB	1	1.010	-	-		D1340284at2759
OrthoFinder	1	1.000	-	-		FOG0005564
OrthoInspector	1	1.000	-	-		oto90245
orthoMCL	1	0.900	-	-		OOG6_108913
Panther	1	1.100	-	-	LDO	PTHR23280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5236
SonicParanoid	1	1.000	-	-		X5201
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.700