Protein Alignment dnr1 and Mylip

DIOPT Version :9

• Sequence 1: NP_001261137.1
• Gene: dnr1 / 37575
• FlyBaseID: FBgn0260866
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_722484.2
• Gene: Mylip / 218203
• MGIID: 2388271
• Length: 445
• Species: Mus musculus
• Alignment Length: 605
• Identity: 166/605 - (27%)
• Similarity: 254/605 - (41%)
• Gaps: 181/605 - (29%)

  Fly     1 MWCIVNLPNGTQQAVKWDPKANGQECLEKVCRAMNIICEMEYFGLEHWTPNQKESQTRQWINLRN 65
            |.|.|..|:.....|:.:.||||::||.:|||.:.|| |::||||: :|.::.||   .|:||||
Mouse     1 MLCYVTRPDAVLMEVEVEAKANGEDCLNQVCRRLGII-EVDYFGLQ-FTGSKGES---LWLNLRN 60

  Fly    66 RLSGDSGSSGSGI-QLMLALRVKFWVPVHFILQESVRNLFYMQARRDLLEGRL-TAPDWSGAAKL 128
            |:|    ....|: ...|.|||||:|..|.||||..|::|::..:..||.|.| .:|:  .|.:|
Mouse    61 RIS----QQMDGLAPYRLKLRVKFFVEPHLILQEQTRHIFFLHIKESLLAGHLQCSPE--QAVEL 119

  Fly   129 AALLCQADGLRFNESSLKADCPMRMRRELAQQQQQQQQQAQQHRLEQQRKEKEHVLSFKKRRLSK 193
            :|||.|.....:|:::
Mouse   120 SALLAQTKFGDYNQNT------------------------------------------------- 135

  Fly   194 QKSMEHIEVCTLPAASTTSCSLQPSPSASASASASASASASASTSACSQTHSNSSSSSPSNSSSQ 258
                                                                             
Mouse   136 ----------------------------------------------------------------- 135

  Fly   259 TGLDERLASNPLRVYEEYFMQPSCEGEPPADYLRQIAVEHGKLAKLQMSLKTAKYWLLKSIQDLE 323
                           .:|..:..||.|..:..|..|..:|.:|..:  |..:|:|.:|:.:..:|
Mouse   136 ---------------AQYSYEDLCEKELSSSTLNSIVAKHKELEGI--SQASAEYQVLQIVSAME 183

  Fly   324 GYGEELFSGVTTNESATRCDIAVGAHGITVCRGGEKQSIPFGAIA------AAKSLRRTFKLEYV 382
            .||.| :..|..:| ..:..|.||..||::|:   :...|...||      |.:|.:..: |...
Mouse   184 NYGIE-WHAVRDSE-GQKLLIGVGPEGISICK---EDFSPINRIAYPVVQMATQSGKNVY-LTVT 242

  Fly   383 DDHNDRKELEIKLPKQPIAAGLYRSITERHAFYVCDKVRGVVTNQFTRDLKGTIASMFM-ENTEL 446
            .:..:...|..|:.....|:||||:|||.||||.||.|...|..|::|||||.:||:|: ||..|
Mouse   243 KESGNSIVLLFKMISTRAASGLYRAITETHAFYRCDTVTSAVMMQYSRDLKGHLASLFLNENINL 307

  Fly   447 GKRYVFDIQHTCREVHDQARRTLHERG-GDLVAEGAEGCSAVAGGLGASAVGEPGVSPWAMALTT 510
            ||:|||||:.|.:||:|.|||.|:..| .|||:...:               .|..||...:.::
Mouse   308 GKKYVFDIKRTSKEVYDHARRALYNAGVVDLVSRSDQ---------------SPPSSPLKSSDSS 357

  Fly   511 GAGGSMAGKIDLAIREKEAREAAIERCVDTRISEAMQCKICMDRAINTVFNPCCHVIACAQCAAR 575
            .:..|..|   |:.::....:..:.     ::.|||.|..|.:..||:.|.||.|.:.|..|||:
Mouse   358 MSCSSCEG---LSCQQTRVLQEKLR-----KLKEAMLCMACCEEEINSTFCPCGHTVCCESCAAQ 414

  Fly   576 CSNCPNCRVKITSVVKIYLP 595
            ..:||.||.::..|..:|||
Mouse   415 LQSCPVCRSRVEHVQHVYLP 434

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnr1	NP_001261137.1	B41	3..>143	CDD:214604	57/141 (40%)
		FERM_N	5..67	CDD:286467	27/61 (44%)
		FERM_M	93..>143	CDD:278785	19/50 (38%)
		FERM_C_MYLIP_IDOL	325..435	CDD:270016	40/115 (35%)
		zf-C3HC4_3	544..589	CDD:290631	19/44 (43%)
Mylip	NP_722484.2	B41	5..190	CDD:214604	72/327 (22%)
		FERM_N	5..67	CDD:286467	29/70 (41%)
		FERM_M	85..190	CDD:278785	35/238 (15%)
		FERM_C_MYLIP_IDOL	185..295	CDD:270016	40/115 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	340..363		3/37 (8%)
		zf-C3HC4_3	383..428	CDD:290631	19/44 (43%)
		Critical for homodimerization. /evidence=ECO:0000250	431..433		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842051
Domainoid	1	1.000	54	1.000	Domainoid score	I11218
eggNOG	1	0.900	-	-		E1_28NMI
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H8309
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7064
OMA	1	1.010	-	-		QHG50100
OrthoDB	1	1.010	-	-		D1340284at2759
OrthoFinder	1	1.000	-	-		FOG0005564
OrthoInspector	1	1.000	-	-		oto93823
orthoMCL	1	0.900	-	-		OOG6_108913
Panther	1	1.100	-	-	LDO	PTHR23280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5236
SonicParanoid	1	1.000	-	-		X5201
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.700