Protein Alignment dnr1 and frm-2

DIOPT Version :10

• Sequence 1: NP_001261137.1
• Gene: dnr1 / 37575
• FlyBaseID: FBgn0260866
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_001040870.1
• Gene: frm-2 / 175848
• WormBaseID: WBGene00001489
• Length: 589
• Species: Caenorhabditis elegans
• Alignment Length: 502
• Identity: 88/502 - (17%)
• Similarity: 159/502 - (31%)
• Gaps: 191/502 - (38%)

  Fly     3 CIVNLPNGTQQAVKWDPKANGQECLEKVCRAMNIICEMEYFGLEHWTPNQKESQTRQWINLRNRL 67
            |.|.|.:|....:.....|.|.|..|:|..::::. |.:||||::..|    ...:.|::...::
 Worm    53 CKVLLLDGAHLNIVVPRNAVGSELYEEVFYSLDLE-ERDYFGLQYTDP----FNVQHWLDPTKKV 112

  Fly    68 SGDSGSSGSGIQLMLALRVKFWV--PVHFILQESVRNLFYMQARRDLLEGRLTAPDWSGAAKLAA 130
               :.....|....|..||||:.  |...:.:|..|..|::|.::|:..|||
 Worm   113 ---AKQVAIGPPFTLRFRVKFFTSEPSSNLKEELTRYQFFLQIKQDISSGRL------------- 161

  Fly   131 LLCQADGLRFNESSLKADCPMRMRRELAQQQQQQQQQAQQHRLEQQRKEKEHVLSFKKRRLSKQK 195
                             .||.::..|||       ..|.|..|.....|....|...:.|...::
 Worm   162 -----------------QCPHQLAIELA-------AFALQSELGDYNPELHTALFISEFRFHPEQ 202

  Fly   196 SMEHIEVCTLPAASTTSCSLQPSPSASASASASASASASASTSACSQTHSNSSSSSPSNSSSQTG 260
                                                                             
 Worm   203 ----------------------------------------------------------------- 202

  Fly   261 LDERLASNPLRVYEEYFMQPSCEGEPPADYLRQIAVEHGKLAKLQMSLKTAKYWLLKSIQDLEGY 325
             ||::   .:.:.|.|   .:|.|:.||.            |:|.. |..|::        :|.|
 Worm   203 -DEKM---EVEILERY---KACRGQTPAQ------------AELNY-LNKARW--------IEMY 239

  Fly   326 GEELFSGVTTNESATRCDIAVGAHGITVCRGGEK---------QSIPFGAIAAAKSLRRTFKLEY 381
            |.::.  :...:......:.:...|:.|..|.:|         |.:.|      |:.:.|..:|.
 Worm   240 GVDMH--IVEGKDGNTYRLGLTPQGMLVFDGPQKIGLFLWEKLQKLDF------KNKKITLVVEE 296

  Fly   382 VDDHNDRKELEI-----KLPKQPIAAGLYRSITERHAFYVCDKVRGVVTN---QFTRDLKGTIAS 438
            ..|.::..::::     .|..:..|...::...|:|||:.. |.|.:..|   ||.|
 Worm   297 DADQSNNGQIQLHTFVFHLTSEKAAKHFWKCAIEQHAFFRL-KSRPIQANRKIQFFR-------- 352

  Fly   439 MFMENTELGKRYVFDIQHTCREVHDQARRTLHERGGDLVAEGAEGCS 485
                   ||..:    ::..|..::    |:|:.|..|  ...:.||
 Worm   353 -------LGSTF----KYRGRTEYE----TIHKEGARL--SRRQSCS 382

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnr1	NP_001261137.1	Ubl1_cv_Nsp3_N-like	1..89	CDD:475130	21/85 (25%)
		FERM_M	91..>148	CDD:459788	9/56 (16%)
		FERM_C_MYLIP_IDOL	325..435	CDD:270016	24/126 (19%)
		RING-HC_IAPs	545..583	CDD:438173
frm-2	NP_001040870.1	B41	53..244	CDD:214604	57/328 (17%)
		FERM_C_NBL4_NBL5	240..336	CDD:270007	17/103 (17%)
		FA	349..394	CDD:462582	12/59 (20%)