Protein Alignment dnr1 and frm-4

DIOPT Version :10

• Sequence 1: NP_001261137.1
• Gene: dnr1 / 37575
• FlyBaseID: FBgn0260866
• Length: 696
• Species: Drosophila melanogaster
• Sequence 2: NP_001249887.1
• Gene: frm-4 / 172189
• WormBaseID: WBGene00001491
• Length: 672
• Species: Caenorhabditis elegans
• Alignment Length: 707
• Identity: 126/707 - (17%)
• Similarity: 237/707 - (33%)
• Gaps: 220/707 - (31%)

  Fly    22 NGQECLEKVCRAMNIICEMEYFGLEHWTPNQKESQTRQWINLRNRLS-------GDSGSSGSGIQ 79
            :.|..|:.||: :..|.|.::.||.:    |...:.|.|::|...::       .:....|....
 Worm    50 SAQTILDYVCQ-LKHIQEKDFLGLRY----QDHHKHRYWLDLTRSINHVVKNFKKEIKKVGKTES 109

  Fly    80 LMLALRVKFWVPVHFILQE-SVRNLFYMQARRDLLEGRLTAPDWSGAAKLAALLCQADGLRFNES 143
            :.|.||.:::......|:: ::|...::|.:||||.|||..|. |.||:||||:.||....:||.
 Worm   110 MTLHLRFRYYPSDPARLRDPNLRYQLFVQLQRDLLHGRLYCPT-SSAAELAALILQAQLGDYNEE 173

  Fly   144 SLKADCPMRMRRELAQQQQQQQQQAQQHRLEQQRKEKEHVLSFKKRRLSKQKSMEHIEVCTLPAA 208
            ....:.....:..|.|..:.:::.|..|        ||     .|.:.|:...:|.:|    .|:
 Worm   174 KHVGNYVSGYKLLLKQTPKLEERIANNH--------KE-----LKGKSSESAELEFLE----KAS 221

  Fly   209 STTSCSLQP----SPSASASASASASASASASTSACSQTHSNSSSSSPSNSSSQTGLDERLASNP 269
            ...:.:..|    .|..:......||.......:..|:||:
 Worm   222 QLDTYAFDPYTIKEPHDTLPVYIGASCKGILIYTGQSRTHN------------------------ 262

  Fly   270 LRVYEEYFMQPSCEGEPPADYLRQIAVEH-GKLAKLQMSLKTAKYWLLKSIQDLEGY-GEELFSG 332
                              .|:...:.|:: ||..:|.:|               |.| |:...:|
 Worm   263 ------------------IDWSELVKVDYSGKEIRLTLS---------------ENYRGQITAAG 294

  Fly   333 VTTNESATRCDIAVGAHGITVCRGGEKQSIPFGAIAAAKSL-RRTFKLEYVDDHNDRKELEIKLP 396
            ..|.        .:..||            |.......||| ::...|:|.            .|
 Worm   295 TPTG--------TLNGHG------------PGSPSIMDKSLTKKPLTLKYT------------CP 327

  Fly   397 KQPIAAGLYRSITERHAFYVCDKVRGVVTNQFTRDLKGTIASMFMENTELGKRYVFDIQHTCREV 461
            ....|..|:..|..:.||:         .....:|:|...:...:.....|..:.|..:...||:
 Worm   328 SGQFAKHLWIHILSQQAFF---------NETSAQDVKLKFSKPRIPLLSRGSTFRFPSKRVYREI 383

  Fly   462 HDQ-ARRTLHERG-------------GDLVAEGAEGCSAVAGGLGASA-------------VGEP 499
            .:: ::..|.::.             .:...|....||.::..|.:.:             |.:|
 Worm   384 EEEDSKSILFDKSIMETSAVMNETTTSNENEESILNCSTISAPLSSGSGVVRYDLLRQTPRVEQP 448

  Fly   500 GVSPWAMALTTGAGGSMAGKIDLAIREKEAREAAIERCVDTR---ISEAMQCKICMDRAINTVFN 561
            .:...::.:||             :.:..|..::.....:|:   :|:.....:.::|.::|  :
 Worm   449 WLKQNSLKVTT-------------VHDNTASSSSSPDNSETQNNNLSKITNLNLSIEREVST--S 498

  Fly   562 PCCHVIACAQCAARCSNCPNCRVKITS-VVKIYLPPELRTSQTGSGATTTSSSSIMGDGQVEEQL 625
            |....:..........:      ..|| .|.:....|:.||.:.:.:|||:       ||
 Worm   499 PSTSPVPIVHTQQHSDH------NSTSFTVHLIKREEVATSSSSTSSTTTT-------GQ----- 545

  Fly   626 LQQQLDEISAAPASLEAGADAGVGVGGMAVGAGAGAGATGPGGQPKVTTAAXNWLCS 682
             ||.|::               .|.|.:|.|.|:|...    |:..|.|.....:|:
 Worm   546 -QQNLEK---------------NGNGKLANGGGSGVDL----GKKTVHTNGTTLICT 582

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dnr1	NP_001261137.1	Ubl1_cv_Nsp3_N-like	1..89	CDD:475130	16/73 (22%)
		FERM_M	91..>148	CDD:459788	22/57 (39%)
		FERM_C_MYLIP_IDOL	325..435	CDD:270016	20/111 (18%)
		RING-HC_IAPs	545..583	CDD:438173	3/37 (8%)
frm-4	NP_001249887.1	B41	29..226	CDD:214604	49/198 (25%)
		PH-like	212..346	CDD:473070	34/226 (15%)