DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ERCC6L2 and Chd3

DIOPT Version :9

Sequence 1:	NP_064592.3	Gene:	ERCC6L2 / 375748	HGNCID:	26922	Length:	1550	Species:	Homo sapiens
Sequence 2:	NP_649111.1	Gene:	Chd3 / 40111	FlyBaseID:	FBgn0023395	Length:	892	Species:	Drosophila melanogaster

Alignment Length:	724	Identity:	193/724 - (26%)
Similarity:	314/724 - (43%)	Gaps:	148/724 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    96 NRKFPSSSVAFKLSDNGDSIPYTINRYLRDYQREGTRFLYGHYIHGGGCILGDDMGLGKTVQVIS 160
            |:|:....|..|          .....|..:|.||..:|...:..|...||.|:||||||:|.:.
  Fly   250 NKKYEDQPVFLK----------EAGLKLHPFQIEGVSWLRYSWGQGIPTILADEMGLGKTIQTVV 304

Human   161 FLAAVLHKKGTREDIENNMPEFLLRSMKKEPLSSTAKKMFLIVAPLSVLYNWKDELDTWG--YFR 223
            ||.: |.|:|                        ..:..|||..|||.|.||:.||:.|.  .:.
  Fly   305 FLYS-LFKEG------------------------HCRGPFLISVPLSTLTNWERELELWAPELYC 344

Human   224 VTVLHGN------RKDN---ELIRVK-------QRKCEIALTTYETLRLCLDELNSLEWSAVIVD 272
            ||.:.|.      ||..   |.:..|       |.|..:.||:||.:.:....|..::|:|::||
  Fly   345 VTYVGGKTARAVIRKHEISFEEVTTKTMRENQTQYKFNVMLTSYEFISVDAAFLGCIDWAALVVD 409

Human   273 EAHRIKNPKARVTEVMKALKCNVRIGLTGTILQNNMKELWCVMDWAVPGLLGSGTYFKKQFSDPV 337
            ||||:::.:::...::...:...::.||||.||||::||:.::::...|.......|:.:|:|
  Fly   410 EAHRLRSNQSKFFRILSKYRIGYKLLLTGTPLQNNLEELFHLLNFLSSGKFNDLQTFQAEFTD-- 472

Human   338 EHGQRHTATKRELATGRKAMQRLAKKMSGWFLRRTKTLIKDQLPKKEDRMVYCSLTDFQKAVYQT 402
                   .:|.|      .::||.:.:....|||.|..:...:|.|.:.:|...|:..||..|:.
  Fly   473 -------VSKEE------QVKRLHEILEPHMLRRLKADVLKSMPPKSEFIVRVELSSMQKKFYKH 524

Human   403 VLETEDVTLILQSSEPCTCRSGQKRRNCCYKTNSHGETVKTLYLSYLTVLQKVANHVALLQAAST 467
            :| |::...:.|......|.                      .|:.:..|:|..||..|..:|:
  Fly   525 IL-TKNFKALNQKGGGRVCS----------------------LLNIMMDLRKCCNHPYLFPSAA- 565

Human   468 SKQQETLIKRICDQVFSRFPDFVQKSKDAAFETLSDPKYSGKMKVLQQLLNHCRKNRDKVLLFSF 532
               :|..|                 |....:|..|..|.|||:.:|.::|...:.:..:|||||.
  Fly   566 ---EEATI-----------------SPSGLYEMSSLTKASGKLDLLSKMLKQLKADNHRVLLFSQ 610

Human   533 STKLLDVLQQYCMASGLDYRRLDGSTKSEERLKIVKEFNS-TQDVNICLVSTMAGGLGLNFVGAN 596
            .||:|:||:.:....|..|.|:|||.|.:.|.|.:..||. ..:..:.|:||.|||||:|...|:
  Fly   611 MTKMLNVLEHFLEGEGYQYDRIDGSIKGDLRQKAIDRFNDPVSEHFVFLLSTRAGGLGINLATAD 675

Human   597 VVVLFDPTWNPANDLQAIDRAYRIGQCRDVKVLRLISLGTVEEIMYLRQIYKQQL---HCVV-VG 657
            .|::||..|||.||:||..||:|:||.:.|.:.|.::..:|||  .:.|:.|.::   |.|| .|
  Fly   676 TVIIFDSDWNPHNDVQAFSRAHRMGQKKKVMIYRFVTHNSVEE--RIMQVAKHKMMLTHLVVRPG 738

Human   658 SENAKRYFEAVQGSKEHQGEL--FGIHNLFKFRSQGSC-----LTKDILEREGQVEAGIMTATTW 715
            .......|     ||:...::  ||..:|||.....:.     ...|:|:|..:   ||....:|
  Fly   739 MGGMTTNF-----SKDELEDILRFGTEDLFKDGKSEAIHYDDKAVADLLDRTNR---GIEEKESW 795

Human   716 LKEGPPAHKLEMPRQPDCQECRGTEQAAEPLAKEACDLCSDFSDEEPVGATGIK-TAKNKAPDSS 779
            ..|...:.|:             ...|.:...:|..|..:|..:.:|.....:. .::.|.|...
  Fly   796 ANEYLSSFKV-------------ASYATKEDHEEHDDYNNDAENTDPFYWENLMGKSQPKLPKKQ 847

Human   780 KASSSPGQL 788
            |..|...|:
  Fly   848 KKQSQQSQV 856

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ERCC6L2	NP_064592.3	TUDOR	21..71	CDD:119391
		HepA	<59..651	CDD:223627	163/573 (28%)
		DEXHc_ERCC6L2	123..371	CDD:350763	74/265 (28%)
		VIGSSK	<1117..1142	CDD:373284
Chd3	NP_649111.1	PHD2_CHD_II	37..79	CDD:277007
		CHROMO	85..147	CDD:237991
		CHROMO	181..233	CDD:214605
		SNF2_N	270..561	CDD:278600	92/353 (26%)
		DEXDc	288..440	CDD:238005	52/176 (30%)
		Helicase_C	585..700	CDD:278689	49/114 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910