DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment px and Gse1

DIOPT Version :9

Sequence 1:	NP_726208.1	Gene:	px / 37573	FlyBaseID:	FBgn0003175	Length:	1995	Species:	Drosophila melanogaster
Sequence 2:	XP_006531208.3	Gene:	Gse1 / 382034	MGIID:	1098275	Length:	1923	Species:	Mus musculus

Alignment Length:	2188	Identity:	434/2188 - (19%)
Similarity:	631/2188 - (28%)	Gaps:	854/2188 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 CFVCGGHGSFEPQPLRIRHNAERPSESYFPFLERHEPPNGVPGVVPGQEYVWACMLCFRSLNEQW 168
            ||:||| |....:.|::......|::.:||||::.||..|..|:......|..|.:|...|.|||
Mouse    24 CFICGG-GIARGKELKLPVRPAGPAQPFFPFLQQQEPAPGARGLSATDGCVLVCAVCRCFLAEQW 87

  Fly   169 DAYERQKKPLLQRIYHMKRVDGKGYIGADVATQSEYAAQVLGLSAEHLTQNGLVEGHGDPYALAR 233
            .|:||.:.|:.:|:|.:||                          .|..........|     ||
Mouse    88 AAFERARTPVDKRVYWLKR--------------------------PHQCDASAAGRRG-----AR 121

  Fly   234 HYSPQQPSHHHHSTSRNASPSPNPIAAVGGGGEFYPRNSTPSSNHNRYLSRPQSRDMPVASPTSR 298
            .::.:.......|...:|...|.|                          .|:....|...|...
Mouse   122 EWNTEDARDSELSELSDADALPEP--------------------------EPEPEPEPEPEPEPE 160

  Fly   299 PPSEPPAMKSAGYAQQKFKLSPAPPVGYQGQAPYHPAQYQQLQQQTAAYHLLQQQVNAGGGATES 363
            |.....:.||..                                         ::...|.||..:
Mouse   161 PEDAHDSSKSGA-----------------------------------------RRRRTGPGAHWA 184

  Fly   364 AHYKGNPYGALPSPGSGPLGPRAASTLEDDNATVLDLRNSSNSSAPPAPRHVGSTASSVSQPSQP 428
            ...:.:....:..|..||..|...     |.|.      ||..:|||       ..||..:.:..
Mouse   185 PEPRASVLRGIQEPWPGPAAPDGT-----DGAA------SSRPAAPP-------ERSSTPEGNDV 231

  Fly   429 QSEVGILDLSMPDK---NSITEVCYVCGDEQRRGSLIELSTVKPRETGRPGPSVPYFPLFNEQHP 490
            ...:|...|..|.:   :|....|||||......|..::. |:.:||....|..|:..|    |.
Mouse   232 AGSLGDEGLERPPRIPADSQARCCYVCGSALSPASQQQIH-VQKQETPAQAPFFPFLWL----HS 291

  Fly   491 RPARSRPKDPRGMIQACLPCYEDLMQQWNVHQASHKPESERSYLLRKRS---------------- 539
            .|..::|....|....|..|:..|..||...:.::.|..:|.|::...|
Mouse   292 PPPGAQPITEAGSTLVCPCCFSSLTHQWQSFELANVPVLQRLYVVPLNSHAPGMASKARRLPREE 356

  Fly   540 --TPAAERTTFVCYTCGTDTPSSQLRLVYCCPNAEREPYYPFIKTMKVYKNASPISPQGMVQVCS 602
              .|.|......||.||.|          |..:|...|
Mouse   357 VPAPTAGLLREACYLCGED----------CTRDARAVP--------------------------- 384

  Fly   603 TCNEKHSGLAEGGPPPASSSIHSAVGGGSPSAGHSLESNSAMYSTSGAITGNSGAQFGGRNSPSE 667
                                                         |..:.||||.
Mouse   385 ---------------------------------------------SRLVNGNSGG---------- 394

  Fly   668 KSLANSDSMSNVRFRPYETNSNNSNSNTARDLKQIRRSDSRPNSPSSSQGAIENGHGQYPCSICK 732

Mouse   395 ----------------------------------------------------------------- 394

  Fly   733 VLCPSNKMDWLSTSAEHMNSHAMHFPCLKANAVTNNNNNNNNTNNNNNNNNNELNSNRVLACKDC 797
                                 :||||.|.......|....|             ....|.:|..|
Mouse   395 ---------------------SMHFPFLSLLPCPPNARPPN-------------KRCEVRSCPKC 425

  Fly   798 KDYLASQWETMDAERVPLEHRRYNIPSPMLTSSSPN--GSRHGAMSINTPPSTPSISSSTPASTS 860
            ...|...|....|     .|.|      .|.||...  |..|.|.|. :.|:...:.:|......
Mouse   426 FSVLEDVWALYRA-----SHNR------ELISSVQGFLGRYHQAFSA-SDPTLSELPASAQGGPP 478

  Fly   861 IYCYLCGLH----SDLTLARVLYASKEGSR-PYFPLLLKHNSLPNAEQLRNNSALV--CTFCYHS 918
            ..||:||..    .:..|: :..||..|.: |:||.|..:...|.|.. .:::.||  |..|||.
Mouse   479 AVCYICGAELGPGKEFQLS-MNPASHLGEKEPFFPFLTVYPPAPRARP-ADSTGLVATCVLCYHD 541

  Fly   919 MLNQWRKYEAQS--PSVNPADRKYNWHDYNCHLC--------GITTYRKRVRALPVNEFPFVKHQ 973
            :|.||.::||::  ..|:...|:|....:.|..|        |:.:.  ||..||:    |:...
Mouse   542 LLGQWLQHEARAAHQPVSAWSRQYQVDTFVCFFCQQEKKRCLGLKSV--RVARLPL----FLYTL 600

  Fly   974 KSDDGLLLENGEYAVV--CLDCYESLRQQASQHDRFGVPISRRAYNWVPQPPPPEDSPESAVARL 1036
            ::...||:::|...::  |::|  .....|.|    || .|:....|        .||.:.|.::
Mouse   601 RASHSLLVDDGRQLIIGACVEC--GTLVCAGQ----GV-ASQGPIGW--------SSPTAGVTKV 650

  Fly  1037 PCG--ERSDRIHINNALRPVPGKKTTSPKQYDKSKEVPPKAGQKRPATSPAPHIPVPHHLQTPPG 1099
            ...  |....:|              :|....:.:.|||.....|...:....:||.....:...
Mouse   651 TSAPLEAPAIVH--------------APASEPELQPVPPTDSLSRGIRTTQEPLPVSSQQSSRDS 701

  Fly  1100 GGAGG--LPGSSVANSPIPSSAGGNALMNHALPNNHIGTPSPQQQHQHQQHQQQQQQQQHQAQQQ 1162
            ....|  |..:.:::.|...|.|..:.........:..||||..
Mouse   702 WDGDGVDLTATGMSHEPKSPSIGMLSTATRTTATVNPLTPSPLN--------------------- 745

  Fly  1163 AQQQAVAAAVQQQLAAGVGLPPGAIG-----AASASSRGSFAAALRTLAKQADIKEEDVGGDRSV 1222
                            |..:|.|:..     :|.|:...|||||||.|||||   ||..|...|.
Mouse   746 ----------------GALVPTGSPATSSTLSAQAAPSSSFAAALRKLAKQA---EEPRGSSLSS 791

  Fly  1223 PTSGAGGPPPSSSGPGS---------------------------------LNSVAGRVGSERPGE 1254
            .:|....|..:.|.|.|                                 :|.|......:..|.
Mouse   792 ESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDSGS 856

  Fly  1255 DRVSSNKKR---SPPSPQPPEKIA------RLSHTP-----------QTASLQPELLAR------ 1293
            ...||.::|   .||..|  ||.|      .|..||           |.:..||..|.|
Mouse   857 RGSSSGRERLLVEPPLAQ--EKAAGPAIPSHLLSTPYPFGLSPGSVVQDSRFQPLNLQRPVHHVV 919

  Fly  1294 ----------SGFQPYRSDERL----MHPAGAFPLEAYSHFAGLQGIPPAFLNPAGLP------- 1337
                      ..|:||.:.|.|    :.|.|..|..|.:::      .|::|.|...|
Mouse   920 PPSTVTEDYLRSFRPYHTAEDLRMSSLPPLGLDPATAAAYY------HPSYLAPHPFPHPAFRMD 978

  Fly  1338 --YTEQLYLEHRYQLFRAAGAHPSHPHAAAL------YPQMASPYSHLYSMMPGAAL---GISPA 1391
              |.........|.:.......|.||.|..|      ||...| :|.|      |||   .:|..
Mouse   979 DSYCLSALRSPFYPIPTPGSLPPLHPSAMHLHLSGVRYPPELS-HSSL------AALHSERMSSL 1036

  Fly  1392 MHDRMKLEEEHRARLAREEEREREIQREKERELREQREKEQREKEQREKEQREREQREKEQREKE 1456
            ..:|::::||    |.||.|||||.:||.:||..::||:|||||| |||| .|||      ||||
Mouse  1037 SAERLQMDEE----LRREREREREREREADREREKEREREQREKE-REKE-LERE------REKE 1089

  Fly  1457 ARERKLRDEERERERERQQLLTASHHYSNQLYSPLNRNLLGSMIPHLNMSLRGPPGALHGLPGMS 1521
             |||:|..:..:|.||::.|...:...:..|                      |...||||.|.|
Mouse  1090 -RERELERQREQRAREKELLAAKALEPTTFL----------------------PVAELHGLRGHS 1131

  Fly  1522 HYHAAAANAQRQSPHGAMGLNLGMAGLPGVPPLGGHGPNLQHHLQQAAMGLAHPGAAGLTHPGFS 1586
                   ..:|..|...:                  .|.....|:...:....|    :.||
Mouse  1132 -------TEERPKPSEQL------------------TPTRAEKLKDVGLQAPKP----VQHP--- 1164

  Fly  1587 AAALGLGAHPHSLNLSHPHMSPHHPASLAHQLPPHTSSAGGGGLSNSIPVTA------------- 1638
                           .||..:||      |.:|...||.|...|..|...||
Mouse  1165 ---------------LHPVPAPH------HTVPSLISSHGIFSLPGSSATTALLIQRTNEEEKWL 1208

  Fly  1639 -------------SSSLS-----ASSPHTSLNLTSSVKLSADQVPTSTPSG---GVSGSGMPPTT 1682
                         .|.:|     ....|..|. ...|...|:..|.||..|   ...||..||
Mouse  1209 ARQRRLRQEKEDRQSQVSEFRQQVLEQHLDLG-RPLVPTEAEHRPESTRPGTNRHEQGSREPP-- 1270

  Fly  1683 SSSHIPNMGHYYHHGHLAAMHAAAAAASGMTPTAAHQQQPLSLPSSPKITPPITPSSSANGGRAG 1747
                       .|.|             |..|..:.:.|..::|::  :..|::...:|...|..
Mouse  1271 -----------QHFG-------------GPPPLISPKPQQHTVPTA--LWNPVSLMDNALETRRA 1309

  Fly  1748 GSPHAMRHH--------IAAAVAAAAQQSAMIDKAATPVTHEPTTLDLTGSNSNSSNQAPSNASS 1804
            .| |::..|        .||......::....:||..|...|.|.||  ..........|..|.|
Mouse  1310 ES-HSLHSHPTAFEPSRQAAVPLVKVERVYCSEKAEEPRKREATPLD--KYQPPPPPPPPREAGS 1371

  Fly  1805 GQP----------------TNHEVNGAESNGASQTESKEHLAIKEDGHKSSPPPVALEKKPATPN 1853
            .:|                :...:.|.:....||..|        .|..|.|      .||.:|.
Mouse  1372 LEPQTFPHGPGPFLTELEKSTQTILGQQRPSLSQATS--------FGELSGP------LKPGSPY 1422

  Fly  1854 AAADKPIHPDS---SP--------------------ENSSRRSASPQS---DANNSL-PAVSVTA 1891
            .      ||.:   .|                    |...||.|..:.   |.::|. .:.....
Mouse  1423 C------HPTARGPDPAYIYDEFLQQRRKLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEV 1481

  Fly  1892 AASGKCKEETPKI-LDSD------------TTATTKTDIEEEKQRARLSV----SPTPTA----- 1934
            .|..:|..|.|.: ||:.            ||...|.::..:|:|.|..:    ||:|.|
Mouse  1482 RAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPPAVQCKR 1546

  Fly  1935 ----PKIMVA---SPDTVSTS-----------------------------------------GGV 1951
                |::.::   |||.::.|                                         ...
Mouse  1547 QTPSPRLALSTRYSPDEMNNSPNFEEKRKFLTFFNLTHISAEKRKDKERLVEMLRAMKQRALSAA 1611

  Fly  1952 TSTTSGTTPPPVVSSSTSSAGKAPALTSDEVSTSAATSAAEPT 1994
            .|.|:.:...|.||.|..:...||..|...|...|:.|....|
Mouse  1612 DSVTNSSRDSPPVSLSEPATQPAPLETDQPVGVPASLSDVPKT 1654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
px	NP_726208.1	MAP7	<1424..>1456	CDD:283355	17/31 (55%)
px	NP_726208.1	DUF4078	<1426..1456	CDD:290039	17/29 (59%)
Gse1	XP_006531208.3	DUF3736	<803..907	CDD:372175	19/105 (18%)
		DUF3736	1442..1582	CDD:372175	27/139 (19%)
		BST2	<1848..1906	CDD:374748
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6300
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000