DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment px and Gse1

DIOPT Version :9

Sequence 1:	NP_726208.1	Gene:	px / 37573	FlyBaseID:	FBgn0003175	Length:	1995	Species:	Drosophila melanogaster
Sequence 2:	XP_017456938.2	Gene:	Gse1 / 307913	RGDID:	1562686	Length:	1919	Species:	Rattus norvegicus

Alignment Length:	2175	Identity:	459/2175 - (21%)
Similarity:	667/2175 - (30%)	Gaps:	817/2175 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   104 CFVCGGHGSFEPQPLRIRHNAERPSESYFPFLERHEPPNGVPGVVPGQEYVWACMLCFRSLNEQW 168
            ||:||| |....:.|::......|::.:||||::.||..|..|:......|..|.:|...|.|||
  Rat    24 CFICGG-GIARGKELKLPVRPAGPAQPFFPFLQQQEPAPGARGLSATDGCVLVCAVCRCFLAEQW 87

  Fly   169 DAYERQKKPLLQRIYHMKR-----VDGKGYIGA-----DVATQSEYAAQVLGLSAEHLTQNGLVE 223
            .|:||.:.|:.:|:|.:||     ....|..||     :.|..||.        :|....:.|.|
  Rat    88 AAFERARTPVDKRVYWLKRPHQCDASAGGRRGAREWNTEDARDSEL--------SELSDADALPE 144

  Fly   224 GHGDPYALARHYSPQ---QPSHHHHSTSRNASPSPNPIAAVGGGGEFYPRNSTPSSNHNRYLSRP 285
            ...:|       .|:   :|...|.||...|..     ...|.|..:.|.   |.::..|.:..|
  Rat   145 PEPEP-------EPEPEPEPEDAHDSTKSGARR-----RRTGSGAHWAPE---PRASVLRGIQEP 194

  Fly   286 QSRDMPVASPTSRPPSEPPAMKSAGYAQQKFKLSPAPPVGYQGQAPYHPAQYQQLQQQTAAYHLL 350
            ..                               |||...|..|.|...||
  Rat   195 WP-------------------------------SPAASDGTDGAASSRPA--------------- 213

  Fly   351 QQQVNAGGGATESAHYKGNPYGALPSPGSGPLGPRAASTLEDDNATVLDLRNSSNSSAPPAPRHV 415
                                  |||...:.|.|...|.:|.|:..           ..||
  Rat   214 ----------------------ALPERSNTPEGSDVAGSLGDEGL-----------ERPP----- 240

  Fly   416 GSTASSVSQPSQPQSEVGILDLSMPDKNSITEVCYVCGDEQRRGSLIELSTVKPRETGRPGPS-V 479
                   ..|:..|:                ..|||||......|..::. |:.:||    || .
  Rat   241 -------RTPADSQA----------------RCCYVCGSALSPASQQQIH-VQKQET----PSQA 277

  Fly   480 PYFPLFNEQHPRPARSRPKDPRGMIQACLPCYEDLMQQWNVHQASHKPESERSYLLRKRS----- 539
            |:|| |...|..|..::|....|....|..|:..|..||...:.::.|..:|.|::...|
  Rat   278 PFFP-FLWLHSPPPGAQPITEAGSTLVCPCCFSSLTHQWQSFELANVPVLQRLYVVPLNSHAPGM 341

  Fly   540 -------------TPAAERTTFVCYTCGTD-------TPSSQLRLVYCCPNAEREPYYPFIKTMK 584
                         .|.|......||.||.|       .||   |||.  .|:....::||:..:.
  Rat   342 ASKARRLPREEGPAPTAGLLREACYLCGEDCTRDARAVPS---RLVN--GNSGGSMHFPFLSLLP 401

  Fly   585 VYKNASPISPQGMVQVCSTCNEKHSGLAEGGPPPASSSIHSAVGGGSPSAGHSLESNSAMYSTSG 649
            ...||.|.:.:..|:.|..|                .|:              ||...|:|..|
  Rat   402 CPPNARPPNKRCEVRSCPKC----------------FSV--------------LEDVWALYRAS- 435

  Fly   650 AITGNSGAQFGGRNSPSEKSLANSDSMSNVRFRPYETNSNNSNSNTARDLKQIRRSDSRPNSPSS 714
                                 .|.:.:|:|
  Rat   436 ---------------------HNRELISSV----------------------------------- 444

  Fly   715 SQGAIENGHGQYPCSICKVLCPSNKMDWLSTSAEHMNSHAMHFPCLKANAVTNNNNNNNNTNNNN 779
             ||.:    |:|
  Rat   445 -QGFL----GRY----------------------------------------------------- 451

  Fly   780 NNNNNELNSNRVLACKDCKDYLASQWETMDAERVPLEHRRYNIPSPMLTSSSPNGSRHGAMSINT 844
                                                 |:.::...|.| |..|..::.|
  Rat   452 -------------------------------------HQAFSASDPTL-SELPTSAQGG------ 472

  Fly   845 PPSTPSISSSTPASTSIYCYLCGLH----SDLTLARVLYASKEGSR-PYFPLLLKHNSLPNAEQL 904
            ||:.              ||:||..    .:..|: :..||..|.: |:||.|..:...|.|..
  Rat   473 PPAV--------------CYICGAELGPGKEFQLS-MNPASHLGEKEPFFPFLTVYPPAPRARP- 521

  Fly   905 RNNSALV--CTFCYHSMLNQWRKYEAQS--PSVNPADRKYNWHDYNCHLC--------GITTYRK 957
            .:::.||  |..|||.:|.||.::||:|  .:|:...|:|....:.|..|        |:.:.
  Rat   522 ADSTGLVATCVLCYHDLLGQWLQHEARSAHQAVSAWSRQYQVDTFVCFFCQQEKKRCLGLKSV-- 584

  Fly   958 RVRALPVNEFPFVKHQKSDDGLLLENGEYAVV--CLDCYESLRQQASQHDRFGVPISRRAYNWVP 1020
            ||..||:    |:...::...||:::|...::  |::|              |..:.  |...:.
  Rat   585 RVARLPL----FLYTLRASHSLLVDDGRQLIIGACVEC--------------GTLVC--AGQGLT 629

  Fly  1021 QPPPPE-DSPESAVARLPCG--ERSDRIHINNALRPVPGKKTTSPKQYDKSKEVPPKAGQKRPAT 1082
            .|.|.. .||.:.|.::...  |....:|              :|....:.:.|||.....|...
  Rat   630 SPGPMGWSSPAAGVTKVTSAPLEAPAIVH--------------APAPEPELQPVPPTDSLSRGTR 680

  Fly  1083 SPAPHIPVPHHLQTPP--GGGAGGLPGSSVANSPIPSSAGGNALMNHALPNNHIGTPSPQQQHQH 1145
            :....:|.|.|.....  .|....|..:.:::.|...|.|..:.........:..||||..
  Rat   681 TTQEPLPAPSHQSNRDIWDGDGVDLTATGMSHEPKSPSIGMLSTATRTTATVNPLTPSPLN---- 741

  Fly  1146 QQHQQQQQQQQHQAQQQAQQQAVAAAVQQQLAAGVGLPPGAIGAASASS-----RGSFAAALRTL 1205
                                             |..:|.|:...:||.|     ..|||||||.|
  Rat   742 ---------------------------------GALVPTGSPATSSALSAQAAPSSSFAAALRKL 773

  Fly  1206 AKQADIKEEDVGGDRSVPTSGAGGPPPSSSGPGS------------------------------- 1239
            ||||   ||..|...|..:|....|..:.|.|.|
  Rat   774 AKQA---EEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVPPGGHSVPSTPPVVTIAPT 835

  Fly  1240 --LNSVAGRVGSERPGEDRVSSNKKR---SPPSPQPPEKIA------RLSHTP-----------Q 1282
              :|.|......:..|....||.::|   .||..|  ||.|      .|..||           |
  Rat   836 KTVNGVWRSESRQDSGSRGGSSGRERLLVEPPLAQ--EKAAGPAIPSHLLSTPYPFGLSPSSVVQ 898

  Fly  1283 TASLQPELLAR----------------SGFQPYRSDERL----MHPAGAFPLEAYSHFAGLQGIP 1327
            .:..||..|.|                ..|:||.:.|.|    :.|.|..|..|.:::      .
  Rat   899 DSRFQPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTAEDLRMSSLPPLGLDPATAAAYY------H 957

  Fly  1328 PAFLNPAGLP---------YTEQLYLEHRYQLFRAAGAHPSHPHAAAL------YPQMASPYSHL 1377
            |::|.|...|         |.........|.:.......|.||.|..|      ||...| :|.|
  Rat   958 PSYLTPHPFPHPAFRMDDSYCLSALRSPFYPIPTPGSLPPLHPSAMHLHLSGVRYPPELS-HSSL 1021

  Fly  1378 YSMMPGAAL---GISPAMHDRMKLEEEHRARLAREEEREREIQREKERELREQREKEQREKEQRE 1439
                  |||   .||....:|::::||    |.||.|||||.:||.:||..::||:||||||:.:
  Rat  1022 ------AALHSERISSLSAERLQMDEE----LRREREREREREREADREREKEREREQREKEREK 1076

  Fly  1440 KEQRERE-QREKE---QREKEARERKL----------------------RDEERERERERQQLLT 1478
            :.:|||| :||:|   |||:.|||::|                      ..|||.:..| |...|
  Rat  1077 ELEREREKERERELERQREQRAREKELLAAKALEPTFLPVAELHGLRGHTTEERPKPSE-QLTPT 1140

  Fly  1479 ASHHYSN---QLYSPLNRNLLGSMIPHLNM-SLRGPPGALHGLPGMSHYHAAAA----------- 1528
            .:....:   |...|:...|.....||..: ||....| :..|||.|   ||.|
  Rat  1141 RAEKLKDTGVQAPKPVQHPLHPVPAPHHTVPSLISSHG-IFSLPGSS---AATALLIQRTNEEEK 1201

  Fly  1529 -----------NAQRQS-----------PHGAMGLNLGMAGLPGVPPLGGHGPNLQHHLQQAAMG 1571
                       ...|||           .|    |:||.   |.||....|.|.
  Rat  1202 WLARQRRLRQEKEDRQSQVSEFRQQVLEQH----LDLGR---PLVPTEAEHRPE----------- 1248

  Fly  1572 LAHPGAAGLTHPGFSAAALGLGAHPHSLNLSHPHMSP---HH--------PASL----------- 1614
                    .|.||.:....|....|.......|.:||   ||        |.||
  Rat  1249 --------STRPGPNRHDQGSREPPQHFGGPPPLISPKPQHHTVPTALWNPVSLMDNTLETRRAE 1305

  Fly  1615 AHQLPPHTSSAGGGGLSNSIPVTASSSLSASSPHTSLNLTSSVKLSADQVPTSTPSGGVSGSGMP 1679
            :|.|..| .:|.......::|:.....:..:..........:..|...|.|...|.       .|
  Rat  1306 SHSLHSH-PTAFEPSRQAAVPLVKVERVYCTEKAEEPRKREATPLDKYQPPPPPPP-------PP 1362

  Fly  1680 PTTSSSHIPNMGHYYHHG---HLAAMHAAAAAASGMTPTAAHQQQPLSLPSSPKITPPITPSSSA 1741
            |..:....|..   :.||   .||.:..:       |.|...||:| ||..:       ||....
  Rat  1363 PREAGGLEPQT---FPHGPGPFLAELEKS-------TQTILGQQRP-SLSQT-------TPFGEL 1409

  Fly  1742 NGGRAGGSPHAMRHHIAAAVAAA-------AQQSAMIDK------AATPVTHEPTTLDLTGSNSN 1793
            .|....|||:.  |..|.....|       .|:..::.|      .......:....||..|...
  Rat  1410 TGSLKSGSPYC--HTTARGPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDE 1472

  Fly  1794 SSNQ---APSNASSGQP------TNHEVNGAESNGASQTESKEHLAIKEDG------HKSSPPPV 1843
            |..:   |.....:.||      ::.::...:..|.:..:.||.|..::..      .:.||.|.
  Rat  1473 SDEEEVRAHLRCVAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPP 1537

  Fly  1844 ALEKKPATPNAAADKPIHPDSSPENSSRRSASPQSDANNSLPAVSVTAAASGKCKEETPKILDSD 1908
            |::.|..||            ||..:.....||  |..|:.|..           ||..|.|
  Rat  1538 AIQCKRQTP------------SPRLALSTRYSP--DEMNNSPNF-----------EEKRKFL--- 1574

  Fly  1909 TTATTKTDIEEEKQRARLSVSPTPTAPK---IMVASPDTVSTSGGVTSTT-----SGTTPPPVVS 1965
             |....|.|..||::.:..:.....|.|   :..|..|:|:|:....|.|     ..|.|.|:
  Rat  1575 -TFFNLTHISAEKRKDKERLVEMLRAMKQRALSAAVADSVATNSSRDSPTISLSEPATQPAPL-- 1636

  Fly  1966 SSTSSAGKAPALTSDEVSTSAATSAAEPTR 1995
             .|......||..|| |..:..|...|..|
  Rat  1637 -ETDQPAGVPASLSD-VPKAVETGRLEQLR 1664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
px	NP_726208.1	MAP7	<1424..>1456	CDD:283355	18/35 (51%)
px	NP_726208.1	DUF4078	<1426..1456	CDD:290039	18/33 (55%)
Gse1	XP_017456938.2	DUF3736	<799..903	CDD:403661	19/105 (18%)
Gse1	XP_017456938.2	DUF3736	1439..1579	CDD:403661	32/168 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6300
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.000