Protein Alignment px and GSE1

DIOPT Version :10

• Sequence 1: NP_726208.1
• Gene: px / 37573
• FlyBaseID: FBgn0003175
• Length: 1995
• Species: Drosophila melanogaster
• Sequence 2: XP_005255916.3
• Gene: GSE1 / 23199
• HGNCID: 28979
• Length: 1925
• Species: Homo sapiens
• Alignment Length: 2094
• Identity: 423/2094 - (20%)
• Similarity: 629/2094 - (30%)
• Gaps: 844/2094 - (40%)

  Fly   263 GGGEFYPR-NSTPSSNHNRYLSRPQSRDMPVASPTSRPPSEPPAMKSAGYAQQKFKLSPAP-PVG 325
            |||   || ........:..||.....|     |.|.|  :|||..:|...|..   :|.| |.|
Human    45 GGG---PRLRGAAEETRDSDLSELSDTD-----PLSEP--DPPARDAASPHQDG---APGPGPRG 96

  Fly   326 YQGQAPYHPAQYQQLQQQTAAYHLLQQQVNAGGGATE-----SAHYKGNPYG------------- 372
            .:|| .:.||......|...|        :|.|.|.|     .||..|.|..
Human    97 GRGQ-EWRPAPGPAPGQGAEA--------SAQGRAEEEGLPAKAHADGEPKSGVRRRRKGVGRHW 152

  Fly   373 ----------ALPSPGSGPL----------GP---RAASTLEDD--NATVLDLRNSSNSSAPPAP 412
                      ::..|..|||          ||   ||..|||..  ..|:.....|.:|.
Human   153 VPEARASVLRSIQDPWQGPLVQEAPADGMKGPPSGRATKTLESRPLGETLRGFCTSEDSD----- 212

  Fly   413 RHVGSTASSVSQPSQP--------QSEVGILDLSMPDKNSITE---VCYVCGDEQRRGSLIELST 466
              :..|:.......||        :...|.:..::.|..:...   .||:||......|..::..
Human   213 --INITSGEEDHKEQPFPGVCNPKEKNSGRVPRALQDSRAAPAEGLCCYICGAPLSPASHHQVHV 275

  Fly   467 VKPRETGRPGPSVPYFPLFNEQHPRPARSRPKDPRGMIQACLPCYEDLMQQWNVHQASHKPESER 531
            .|..:..:    .|:|| |...|..|..::|....|....|..|:..|.|||...:.::.|..:|
Human   276 QKQEKLAQ----APFFP-FLWLHSPPPGAQPISEGGSTLVCASCFSSLTQQWQSFELANVPVLQR 335

  Fly   532 SYLL-----------RKRSTPAAE-----RTTFVCYTCGTDTPSSQLRLVYCCPNAEREP----- 575
            .|::           :.|..|..|     .....||.||.|          |.|:|...|
Human   336 LYVVPLDSHAPGMASKGRRLPREEGLPSGALREACYLCGED----------CTPDARAVPSRILN 390

  Fly   576 -------YYPFIKTMKVYKNASPISPQGMVQVCSTCNEKHSGLAEGGPPPASSSIHSAVGGGSPS 633
                   ::||:..:....||...:.:..|:.|..|                .|:
Human   391 GNARSAMHFPFLSLLPCPPNAQGPNKRCEVRSCPKC----------------FSV---------- 429

  Fly   634 AGHSLESNSAMYSTSGAITGNSGAQFGGRNSPSEKSLANSDSMSNVRFRPYETNSNNSNSNTARD 698
                ||...|:|                      ::..|.:.:::|
Human   430 ----LEDVWALY----------------------RACQNEELITSV------------------- 449

  Fly   699 LKQIRRSDSRPNSPSSSQGAIENGHGQYPCSICKVLCPSNKMDWLSTSAEHMNSHAMHFPCLKAN 763
                             ||.:    |:|
Human   450 -----------------QGFL----GRY------------------------------------- 456

  Fly   764 AVTNNNNNNNNTNNNNNNNNNELNSNRVLACKDCKDYLASQWETMDAERVPLEHRRYNIPSPMLT 828
                                                                 |:.::...|.|
Human   457 -----------------------------------------------------HQAFSASDPAL- 467

  Fly   829 SSSPNGSRHGAMSINTPPSTPSISSSTPASTSIYCYLCGLH----SDLTLARVLYASKEGSR-PY 888
            |..|..::.|.:||                    ||:||..    .:..| .|..||:.|.: |:
Human   468 SELPASAQGGPVSI--------------------CYICGAELGPGKEFQL-NVNPASRLGEKEPF 511

  Fly   889 FPLLLKHNSLPNAEQLRNNSALV--CTFCYHSMLNQWRKYEAQSP--SVNPADRKYNWHDYNCHL 949
            ||.|..:...|.|..: :::.||  |..|||.:|.||.::||:|.  :|:...|:|....:.|..
Human   512 FPFLTVYPPAPRARPV-DSTGLVATCVLCYHDLLAQWLQHEARSSHHAVSAWSRQYQVETFVCFF 575

  Fly   950 C--------GITTYRKRVRALPVNEFPFVKHQKSDDGLLLENGEYAVV--CLDC------YESLR 998
            |        |:.:.  ||..||:    |:...::...||:::|:..::  |::|      .:.|.
Human   576 CQQEKKRCLGLKSV--RVARLPL----FLYTLRASHSLLVDDGQQLIIGACVECGTLVCAGQGLT 634

  Fly   999 QQASQHDRFGVPISRRAYNWVPQPPPPEDSPESAVARLPCGERSDRIHINNALRPVPGKKTTSPK 1063
            :|.        |:|     |        .||.:|..:..||.    :..:.|..|...:..|.|:
Human   635 RQG--------PMS-----W--------SSPVAAATKPVCGS----LEASAASHPPTRESETRPR 674

  Fly  1064 QYDKSKEVPPKAGQK-RPATSPAPHIPVPHHLQTPPGGGAGGLPGSSVANSPIPSSAGGNALMNH 1127
            ...::....|:..|: |||..          ||:........|.|:.:::.|...|.|..:....
Human   675 APTETLPRGPRMAQELRPAQC----------LQSSREEDGPDLTGAGMSHEPKSPSLGMLSTATR 729

  Fly  1128 ALPNNHIGTPSPQQQHQHQQHQQQQQQQQHQAQQQAQQQAVAAAVQQQLAAGVGLPPGAIGAASA 1192
            .....:..||||..                                     |..:|.|:...:||
Human   730 TTATVNPLTPSPLN-------------------------------------GALVPSGSPATSSA 757

  Fly  1193 SS-----RGSFAAALRTLAKQADIKEEDVGGDRSVPTSGAGGPPPSSSGPGS------------- 1239
            .|     ..|||||||.|||||   ||..|...|..:|....|..:.|.|.|
Human   758 LSAQAAPSSSFAAALRKLAKQA---EEPRGSSLSSESSPVSSPATNHSSPASTPKRVPMGPIIVP 819

  Fly  1240 --------------------LNSVAGRVGSERPGEDRVSSNKKR---SPPSPQP----PEKIARL 1277
                                :|.|......:..|....|..::|   .||.||.    |...:.|
Human   820 PGGHSVPSTPPVVTIAPTKTVNGVWRSESRQDAGSRSSSGGRERLIVEPPLPQEKAGGPAIPSHL 884

  Fly  1278 SHTPQTASLQPELLARS---------------------------GFQPYRSDERL----MHPAGA 1311
            ..||....|.|..:.:.                           .|:||.:.:.|    :.|.|.
Human   885 LSTPYPFGLSPSSVVQDSRFPPLNLQRPVHHVVPPSTVTEDYLRSFRPYHTTDDLRMSSLPPLGL 949

  Fly  1312 FPLEAYSHFAGLQGIPPAFLNPAGLP---------YTEQLYLEHRYQLFRAAGAHPSHPHAAAL- 1366
            .|..|.:::      .|::|.|...|         |.........|.:.......|.||.|..|
Human   950 DPATAAAYY------HPSYLAPHPFPHPAFRMDDSYCLSALRSPFYPIPTPGSLPPLHPSAMHLH 1008

  Fly  1367 -----YPQMASPYSHLYSMMPGAALGISPAMHDRMKLEEEHRARLAREEEREREIQREKERELRE 1426
                 ||...| :|.|.::......|:|.   :|::::||    |.||.|||||  ||:|||...
Human  1009 LSGVRYPPELS-HSSLAALHSERMSGLSA---ERLQMDEE----LRRERERERE--REREREADR 1063

  Fly  1427 QREKEQREKEQREKEQREREQREKEQREKEARERKLRDEERERERERQQLLTASHHYSNQLYSPL 1491
            :|||| ||:| |||   ||||.::.:|||| |||:|..:..:|.||: :||.|         ..|
Human  1064 EREKE-RERE-REK---EREQEKEREREKE-RERELERQREQRAREK-ELLAA---------KAL 1112

  Fly  1492 NRNLLGSMIPHLNMSLRGPPGALHGLPGMSHYHAAAANAQRQSPHGAMGLNLGMAGLPGVPPLGG 1556
            ..:.|             |...||||.|    |   |..:|..|...:
Human  1113 EPSFL-------------PVAELHGLRG----H---ATEERGKPSEQL----------------- 1140

  Fly  1557 HGPNLQHHLQQAAMGLAHPGAAGLTHPGFSAAALGLGAHPHSLNLSHPHMSPHHPASLAHQLPPH 1621
             .|.....|:.|.:....|    :.||                  .||..:||      |.:|..
Human  1141 -TPTRAEKLKDAGLQAPKP----VQHP------------------LHPVPTPH------HTVPSL 1176

  Fly  1622 TSSAGGGGLSNSIPVTA--------------------------SSSLS-----ASSPHTSLNLTS 1655
            .|:.|...|.:|...||                          .|.:|     ....|..:. ..
Human  1177 ISNHGIFSLPSSSAATALLIQRTNEEEKWLARQRRLRQEKEDRQSQVSEFRQQVLEQHLDMG-RP 1240

  Fly  1656 SVKLSADQVPTSTPSGGVSG------------SGMPPTTSSSHIPNMGH---------------- 1692
            .|...|:..|.||...|.:.            .|.||..|..  |.: |
Human  1241 PVPAEAEHRPESTTRPGPNRHEPGGRDPPQHFGGPPPLISPK--PQL-HAAPTALWNPVSLMDNT 1302

  Fly  1693 --------YYHHGHLAAMHAAAAAASGMT-------PTAAHQ----QQPLSLPSSPKITPPITPS 1738
                    :..|.|.||...:..||..:.       |..|.:    ::|..|   .|..||..|.
Human  1303 LETRRAESHSLHSHPAAFEPSRQAAVPLVKVERVFCPEKAEEGPRKREPAPL---DKYQPPPPPP 1364

  Fly  1739 SSANGGRAGGSPHAMRHH---------IA----AAVAAAAQQSAMIDKAAT-------------- 1776
                  |.|||   :.|.         :|    :......||.|.:.:|||
Human  1365 ------REGGS---LEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATFGELSGPLKPGSPY 1420

  Fly  1777 --PVTHEPTT----------------------------------LDLTGSNSNSSNQ---APSNA 1802
              ||...|..                                  .||..|...|..:   |....
Human  1421 RPPVPRAPDPAYIYDEFLQQRRRLVSKLDLEERRRREAQEKGYYYDLDDSYDESDEEEVRAHLRC 1485

  Fly  1803 SSGQP------TNHEVNGAESNGASQTESKEHLAIKEDG------HKSSPPPVALEKKPATPNAA 1855
            .:.||      ::.::...:..|.:..:.||.|..::..      .:.||.|..::.|..||
Human  1486 VAEQPPLKLDTSSEKLEFLQLFGLTTQQQKEELVAQKRRKRRRMLRERSPSPPTIQSKRQTP--- 1547

  Fly  1856 ADKPIHPDSSPENSSRRSASPQSDANNSLPAVSVTAAASGKCKEETPKILDSDTTATTKTDI--E 1918
                     ||..:.....||  |..|:.|..           ||..|.|    |....|.|  |
Human  1548 ---------SPRLALSTRYSP--DEMNNSPNF-----------EEKKKFL----TIFNLTHISAE 1586

  Fly  1919 EEKQRARLSVSPTPTAPKIMVASPDTVSTSGGVTSTTSGTTPPPVVSSSTSSAGKAPALTSDEVS 1983
            :.|.:.||        .:::.|......::....|.|:.....|.||.|..:..:|.......|.
Human  1587 KRKDKERL--------VEMLRAMKQKALSAAVADSLTNSPRDSPAVSLSEPATQQASLDVEKPVG 1643

  Fly  1984 TSAATS----AAEP 1993
            .:|:.|    ||||
Human  1644 VAASLSDIPKAAEP 1657

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
px	NP_726208.1	dnaA	237..>428	CDD:455861	49/209 (23%)
		MAP7	1424..>1457	CDD:461709	17/32 (53%)
		DUF5585	1596..1984	CDD:465521	100/545 (18%)
GSE1	XP_005255916.3	PHA03247	<638..978	CDD:223021	82/412 (20%)
		DUF3736	<801..905	CDD:463624	18/103 (17%)
		DUF3736	1440..1581	CDD:463624	29/169 (17%)
		Smc	<1829..>1906	CDD:440809