DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and Ache

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_038945765.1	Gene:	Ache / 83817	RGDID:	69313	Length:	616	Species:	Rattus norvegicus

Alignment Length:	588	Identity:	176/588 - (29%)
Similarity:	262/588 - (44%)	Gaps:	101/588 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LGTGQTKE--------LATKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSW 83
            ||.|...|        :..:.|||:|.:.:.  .|.|..:|.|||||:||||..||..|:|...|
  Rat    25 LGGGARAEGREDPQLLVRVRGGQLRGIRLKA--PGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPW 87

  Fly    84 QGVRDCTYAREKPMQR-NSITNAAEG----------SEDCLYLNVYAKRLESPKPLPVMVWIFGG 137
            .|:.|.|..:....|. :::....||          |||||||||:........|.||::||:||
  Rat    88 SGILDATTFQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLIWIYGG 152

  Fly   138 GFQVGGASRELYGPDYFMK-HDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKE 201
            ||..|.:|.::|...:..: ...:||::|||||..|||:|.... ..|||.||.||..||:||:|
  Rat   153 GFYSGASSLDVYDGRFLAQVEGTVLVSMNYRVGTFGFLALPGSR-DAPGNVGLLDQRLALQWVQE 216

  Fly   202 NIASFNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQR--- 263
            |||:|.|||.|:|:||||||.||..:.:.:..:|.|||||::|||:....|||....:..:|
  Rat   217 NIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATL 281

  Fly   264 ----LGKELGYAGNLESEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEILAFAPVIEPYVGDD 324
                :|...|.||.  ::.||:...:..||..|..:...::.||....:   :|.||::   ||
  Rat   282 LARLVGCPPGGAGG--NDTELISCLRTRPAQDLVDHEWHVLPQESIFRF---SFVPVVD---GD- 337

  Fly   325 CVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSYRTTLDDP--------LYMLSAFEAIIPKQVR 381
             .:..:.:..:::.....:.:::|....||  ||......|        |...:.|.|.:...|.
  Rat   338 -FLSDTPEALINTGDFQDLQVLVGVVKDEG--SYFLVYGVPGFSKDNESLISRAQFLAGVRIGVP 399

  Fly   382 DAIDKEELAEMVRRLKKSYFDDPDRASMELYECLHILSIKNFWHDIHRT------LLARLAYATN 440
            .|.|....|.::......:.:||          .|:....:.....|..      |..||| |..
  Rat   400 QASDLAAEAVVLHYTDWLHPEDP----------AHLRDAMSAVVGDHNVVCPVAQLAGRLA-AQG 453

  Fly   441 LPTYLYRFDMDSPHFNHYRILKCGKKVRGVCHADDISYMFYGILSSKLDKNSPEYRTIERLVGMW 505
            ...|.|.|:       |...........||.|..:|.::|...|...|:....|....:||:..|
  Rat   454 ARVYAYIFE-------HRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTVEERIFAQRLMKYW 511

  Fly   506 TSFATTGDPN--CEIIAPVKWDP------------LRPGGVENCLNIADGLEFIPLPESKQFVVW 556
            |:||.|||||  .:..:| :|.|            |:|      |.:..||      .::....|
  Rat   512 TNFARTGDPNDPRDSKSP-RWPPYTTAAQQYVSLNLKP------LEVRRGL------RAQTCAFW 563

  Fly   557 DSF 559
            :.|
  Rat   564 NRF 566

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	170/560 (30%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	50/105 (48%)
Ache	XP_038945765.1	COesterase	37..563	CDD:395084	170/571 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810