DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and Ces2f

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001073334.2	Gene:	Ces2f / 71903	MGIID:	1919153	Length:	561	Species:	Mus musculus

Alignment Length:	518	Identity:	159/518 - (30%)
Similarity:	237/518 - (45%)	Gaps:	87/518 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCTYAREKPMQRNS 101
            |..||::|:...........::|.|||||:||||.|||..|:.|..|.||||.|......:|.:.
Mouse    38 THTGQVRGKFVHLTDIKAGAHNFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSQPAMCLQNDD 102

  Fly   102 ITNAAEG-------------SEDCLYLNVYA-KRLESPKPLPVMVWIFGGGFQVGGASRELY-GP 151
            |.| .||             ||||||||:|. ...:....||||||:.|||...|.||  :| |.
Mouse   103 IVN-LEGLKIIKMILPPFSMSEDCLYLNIYTPAHAQEGSNLPVMVWLHGGGLVAGMAS--MYDGS 164

  Fly   152 DYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVF 216
            ......|:::|...||:|:.||.|..|::.:  ||.|..||..||.||::|||:|.|:|:|:|:|
Mouse   165 VLAATEDVVVVVTQYRLGIPGFYSTGDEQAR--GNWGFLDQTAALHWVQQNIANFGGNPDSVTLF 227

  Fly   217 GESAGGAST--HILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQRL-GKELGYAGNLESEK 278
            |:||||.|.  |:|....|  |||||||::||.||.. ...||.  |:.: .|....:|...|..
Mouse   228 GQSAGGTSVSFHVLSPVSQ--GLFHRAIMESGVALLP-TIIPDS--PEMIFTKVANLSGCETSNS 287

  Fly   279 ELLEFFQQIPASKLAQYCNSIVTQEEQRDYEILAFAPVIE--PYVGDDCVIPKSQQEQLSSAWGN 341
            |.|                 :.....:.:.||||.:....  |.|.|...:|:..::.|:||..:
Mouse   288 EAL-----------------VRCLRGKSEAEILAMSKAFRFMPAVVDGKFLPRHPKKLLASADFH 335

  Fly   342 SIPMIIG------GTSFEGLFSYRTTLD-------DPLYMLSAFEAIIPKQVRDAIDKEELAEMV 393
            .:|.|||      |.....:|.:..|:.       ..:..::..:.::|.:..|.:.:|.|.:.
Mouse   336 PVPSIIGVNNDEYGWIIPKIFKFSQTIRKINRNNLKAIMKITTEQMMLPSECGDLLIEEYLRDT- 399

  Fly   394 RRLKKSYFDDPDRASMELYECLHILSIKNFWHDIHRTLLARLAYATNLPTYLYRFDMDSPHFNHY 458
                    :||....|:..|     .|.:|...|....:||. ..::.|.|.|.|...|....::
Mouse   400 --------EDPWTLQMQFRE-----MIGDFLIIIPALQVARF-QRSHAPVYFYEFQHRSSLLKYF 450

  Fly   459 R--ILKCGKKVRGVCHADDISYMFYG--ILSSKLDKNSPEYRTIERLVGMWTSFATTGDPNCE 517
            |  .:|..       |.|:: |:.:|  ....|....:.|.....:::..|.:||..|:||.|
Mouse   451 RPWHVKAD-------HGDEL-YLIFGSFFWGLKFSFTAEEKLLSRKMMKYWANFARYGNPNSE 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	159/518 (31%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	45/106 (42%)
Ces2f	NP_001073334.2	COesterase	32..540	CDD:395084	159/518 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832766
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.640