DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and Bche

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_075231.1	Gene:	Bche / 65036	RGDID:	619996	Length:	597	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	155/545 - (28%)
Similarity:	243/545 - (44%)	Gaps:	116/545 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 GTGQTKE---LATKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDC 89
            |...|:|   :.||.|:::|.....|  |....:|.|||:||||:|.|||:.|||.:.|..|.:.
  Rat    19 GKSHTEEDVIITTKTGRVRGLSMPIL--GGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDVYNA 81

  Fly    90 TYAREKPMQRNSITNAAEG-------------SEDCLYLNVYAKRLESPKPLPVMVWIFGGGFQV 141
            |.......|  :|..|..|             |||||||||:.. :..||...||||::|||||.
  Rat    82 TKYANSCYQ--NIDQAFPGFQGSEMWNPNTNLSEDCLYLNVWIP-VPKPKNATVMVWVYGGGFQT 143

  Fly   142 GGASRELYGPDYFMKHD-ILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIAS 205
            |.:|..:|...:..:.: :::|::|||||.||||:..... :.|||.||.||..||:|::.|||:
  Rat   144 GTSSLPVYDGKFLTRVERVIVVSMNYRVGALGFLAFPGNS-EAPGNMGLFDQQLALQWIQRNIAA 207

  Fly   206 FNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQR---LGKE 267
            |.|:|:|:|:||||||.||..:.:...|:..||.|||::|||:...||.:...:...|   |.|.
  Rat   208 FGGNPKSVTLFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTLAKF 272

  Fly   268 LGYAGNLESEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEILAFAPVIEPYVGDDCVIPKSQQ 332
            :|.  :.|:|||::...:.....::......::..:..|.   :.|.|.::   ||.........
  Rat   273 IGC--SKENEKEIITCLRSKDPQEILLNEKLVLPSDSIRS---INFGPTVD---GDFLTDMPHTL 329

  Fly   333 EQLSSAWGNSIPMIIG-----GTSF----------------------EGLFSYRTTLDDPLYMLS 370
            .||...  .:..:::|     ||:|                      |||..|     .|.....
  Rat   330 LQLGKV--KTAQILVGVNKDEGTAFLVYGAPGFSKDNDSLITRREFQEGLNMY-----FPGVSSL 387

  Fly   371 AFEAIIPKQVRDAIDKEELAEMVRRLKKSYFDD---------PDRASMELYECLHILSIKNFWHD 426
            ..|||:...|      :.|.:....:.:..|||         |   ::|..:....|.|..|::.
  Rat   388 GKEAILFYYV------DWLGDQTPEVYREAFDDIIGDYNIICP---ALEFTKKFAELEINAFFYY 443

  Fly   427 I-HRTLLARLAYATNLPTYLYRFDMDSPHFNHYRILKCGKKVRGVCHADDISYMFYGILSSKLDK 490
            . ||:  ::|.:    |.::                       ||.|..:|.::|...|..:::.
  Rat   444 FEHRS--SKLPW----PEWM-----------------------GVMHGYEIEFVFGLPLERRVNY 479

  Fly   491 NSPEYRTIERLVGMWTSFATTGDPN 515
            ...|......::..|.:||..|.||
  Rat   480 TRAEEIFSRSIMKTWANFAKYGHPN 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	155/545 (28%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	48/105 (46%)
Bche	NP_075231.1	COesterase	21..545	CDD:278561	154/543 (28%)
		Aes	<120..>272	CDD:223730	64/153 (42%)
		AChE_tetra	560..594	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810