Protein Alignment gas and NLGN4X

DIOPT Version :9

• Sequence 1: NP_611678.1
• Gene: gas / 37572
• FlyBaseID: FBgn0034736
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: XP_005274621.1
• Gene: NLGN4X / 57502
• HGNCID: 14287
• Length: 836
• Species: Homo sapiens
• Alignment Length: 619
• Identity: 176/619 - (28%)
• Similarity: 268/619 - (43%)
• Gaps: 168/619 - (27%)

  Fly    37 TKYGQLKGQQRRTLYDGE---PYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCT-YAREKPM 97
            |.||:::|  .||....|   |...:.|:|:|.||.||.||:.|:|||||.|:|:.| :|...|.
Human    50 TNYGKIRG--LRTPLPNEILGPVEQYLGVPYASPPTGERRFQPPEPPSSWTGIRNTTQFAAVCPQ 112

  Fly    98 QRNS-------------------ITNAAEGSEDCLYLNVYAKRLE-------------------- 123
            ..:.                   :|...:.:|||||||:|....:
Human   113 HLDERSLLHDMLPIWFTANLDTLMTYVQDQNEDCLYLNIYVPTEDGANTKKNADDITSNDRGEDE 177

  Fly   124 ------SPKPLPVMVWIFGGGFQVG------GASRELYGPDYFMKHDILLVTINYRVGVLGFLSL 176
                  |.|  ||||:|.||.:..|      |:....||       :::::|||||:|:|||||.
Human   178 DIHDQNSKK--PVMVYIHGGSYMEGTGNMIDGSILASYG-------NVIVITINYRLGILGFLST 233

  Fly   177 KDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGESAGGASTHILMQTEQARGLFHRA 241
            .|:..|  ||.||.||||||||::||:.:|.|||:.:|:||..||.:...:|..:..:.|||.:|
Human   234 GDQAAK--GNYGLLDQIQALRWIEENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKA 296

  Fly   242 IVQSGSALCAWAT--QPDRKWPQRLGKELGYAGNLESEKELLEFFQQIPASKLAQYCNSIVTQEE 304
            |:|||:||.:||.  || .|:.:.|..::|.  |:....:::|..:.....:|.|...:..|
Human   297 IIQSGTALSSWAVNYQP-AKYTRILADKVGC--NMLDTTDMVECLRNKNYKELIQQTITPAT--- 355

  Fly   305 QRDYEILAFAPVIEPYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSYRTTLDDPLYML 369
               |.| ||.|||:   ||  |||...|..:......:..:::|....|||......:|:.
Human   356 ---YHI-AFGPVID---GD--VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFVDGIVDNE---- 407

  Fly   370 SAFEAIIPK----QVRDAID--------KEELAEMVRRLKKSYFDDPDRASMEL-YECLHILSIK 421
               :.:.|.    .|.:.:|        |:.|.|.:   |..|.|..|:.:.|. .:.|..|...
Human   408 ---DGVTPNDFDFSVSNFVDNLYGYPEGKDTLRETI---KFMYTDWADKENPETRRKTLVALFTD 466

  Fly   422 NFW-------HDIHRTLLARLAYATNLPTYLYRFDMDSPHFNHYRILKCGKKVR----GVCHADD 475
            :.|       .|:|      ..|.:  |||.|.|      ::|     |..:::    ...|.|:
Human   467 HQWVAPAVATADLH------AQYGS--PTYFYAF------YHH-----CQSEMKPSWADSAHGDE 512

  Fly   476 ISYMFYGI--------LSSKLDKNSPEYRTIERLVGMWTSFATTGDPNCEIIAPVKWDPLRPGGV 532
            :.|:| ||        .|....||......:  ::..||:||.|||||..:....|:...:|...
Human   513 VPYVF-GIPMIGPTELFSCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRF 574

  Fly   533 ENCLNIADGLEFIPLPESKQFVVWDSFYTRESLY 566
            |.                   |.|..:..::.||
Human   575 EE-------------------VAWSKYNPKDQLY 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	171/585 (29%)
		Aes	<117..>222	CDD:223730	49/136 (36%)
NLGN4X	XP_005274621.1	COesterase	42..610	CDD:278561	176/619 (28%)
		Aes	<179..>286	CDD:223730	50/117 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142821
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740