DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and ces2a

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001070720.1	Gene:	ces2a / 566132	ZFINID:	ZDB-GENE-061013-99	Length:	555	Species:	Danio rerio

Alignment Length:	573	Identity:	169/573 - (29%)
Similarity:	245/573 - (42%)	Gaps:	179/573 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 KYGQLKGQQRRTLYDGEP--YYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCTYAREKP---M 97
            |:|.::||..:.  .|.|  ...:.||||||||||..|..||||...|:|:|:.|   |.|   :
Zfish    32 KHGSVRGQYVKA--KGSPAVVEQYLGIPFAQPPVGPHRLAAPQPVQGWEGIRNAT---EHPLMCL 91

  Fly    98 QRNSITNA----------AEG-SEDCLYLNVY--AKRLESPKPLPVMVWIFGGGFQVGGAS--RE 147
            |...|..|          |.| ||||||||||  ::|.||.| ||||:||.|||..:|||.  :|
Zfish    92 QNPDILPAIAKAIDLEVTAIGVSEDCLYLNVYTPSQRAESEK-LPVMIWIHGGGLAMGGACMFKE 155

  Fly   148 LY---GPDYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGD 209
            |.   |........:::|.|.||:|:||:.|..|:..|  ||.|..|||.||:||::||.:|.||
Zfish   156 LCLYDGTPLAAYEKVVVVVIQYRLGILGYFSTGDQHAK--GNWGFLDQIAALQWVQQNIEAFGGD 218

  Fly   210 PESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQRLGKELGYAGNL 274
            |:|:|:.||||||.|..:|..:...:|||.|||.|||.|...                 ||
Zfish   219 PQSVTIAGESAGGISASLLTLSPMTKGLFQRAIFQSGVATVK-----------------GY---- 262

  Fly   275 ESEKELLEFFQQIPASKLAQYCNSIVTQ-------------EEQRDYEILAFAPV--IEPYVGDD 324
                     |.:.|::......|  :|:             .|..:.:|:..|..  |.|....|
Zfish   263 ---------FVKDPSTHAQVIAN--ITECDFSSSEVLVKCIREMTEEQIIKAAQKKGIFPGAAVD 316

  Fly   325 CVIPKSQQEQ-LSSAWGNSIPMIIGGTSFEGLFSY----------------RTTLDDPLYMLSA- 371
            ....|:|.|: |.|.....:|::||.|:.|  |.:                .....|.|.:|:|
Zfish   317 GEFIKAQPEEILKSKDFQKVPILIGTTNHE--FGWMLPQIFLPKEWVKGMDTKAAKDRLGLLNAD 379

  Fly   372 -------------FE-AIIPKQVRDAIDKEELAEMVRRLKKSYFDDPDRASMELYECLHILSIKN 422
                         |: |..|:::|||     ..|::.               :::..:..:::.:
Zfish   380 GASGANGIIADEYFKNAKTPEEIRDA-----FTELLG---------------DIFMVIPSITVAS 424

  Fly   423 FWHDIHRTLLARLAYATNLPTYLYRFDMDSPHFNHYR--ILKCGKKVRGVCHADDISYMF----- 480
            :    ||        ...:|.|:|.|.......|.:|  .:|..       ||||:.::|
Zfish   425 Y----HR--------EAGVPVYMYEFQHGPSTANKFRPSFVKAD-------HADDVGFVFGACFW 470

  Fly   481 ------YGILS---SKLDKNSPEYRTIERLVGMWTSFATTGDPNCEIIAPVKW 524
                  .|.|:   ::|.:...:||         .:|..||.||   .|||.|
Zfish   471 DVHVKGLGTLTEEENQLCRTVMKYR---------ANFIRTGSPN---PAPVPW 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	169/573 (29%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	53/111 (48%)
ces2a	NP_001070720.1	COesterase	21..541	CDD:278561	169/573 (29%)
ces2a	NP_001070720.1	Aes	<122..346	CDD:223730	88/258 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575353
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840