DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and ces2b

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_021326380.1	Gene:	ces2b / 561967	ZFINID:	ZDB-GENE-041014-96	Length:	1611	Species:	Danio rerio

Alignment Length:	565	Identity:	182/565 - (32%)
Similarity:	255/565 - (45%)	Gaps:	113/565 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCTYAREKPM--QR 99
            ||.|.|:|.............|:..||||:.|||.||...|||..:||||||.|  ::.||  |.
Zfish   559 TKLGSLRGSYMMAKGKDSVISSYFAIPFAKSPVGPLRLTPPQPADAWQGVRDAT--KQPPMCLQP 621

  Fly   100 NSI-----------TNAAEGSEDCLYLNVYA-KRLESPKPLPVMVWIFGGGFQVGGASRELYGPD 152
            ..:           |...|.||||||||:|. .:....|.|||||||.|||...|.||
Zfish   622 KEVMVDLLATMPLKTEFPEVSEDCLYLNIYTPSKPGDNKKLPVMVWIHGGGLAFGSAS------- 679

  Fly   153 YFMKH------DILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPE 211
            .|..|      ||::|.:.||:|:|||.|..|:.  .|||.||.||:.||:||:|||.||.|||.
Zfish   680 IFDAHALAAYQDIVVVMVQYRLGLLGFFSTGDEH--APGNYGLLDQVAALQWVQENIHSFGGDPG 742

  Fly   212 SITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQRLGKELGYAG--NL 274
            |:|||||||||.|..:|:.:..:..||||||.:||:|.......||   |....:.||...  ::
Zfish   743 SVTVFGESAGGVSASLLVLSPLSANLFHRAIAESGTAAMNAIMSPD---PLSTARSLGNVSGCDI 804

  Fly   275 ESEKELLEFFQQIPASKLAQYCNSIVTQEE----QRDYEILAFAPVIEPYVGDDCVIPKSQQEQL 335
            .|.|::::             |...:|:|:    .|:..:|.|...:     |...:|||..|.|
Zfish   805 SSTKKIVD-------------CVMQMTEEDILKIAREQVLLRFGVTV-----DGQFLPKSVDELL 851

  Fly   336 SSAWGNSIPMIIGGTSFEGLFSYRTTLDDPLYMLSAFEAIIPKQVRDAIDKEELAEMVRRLKKSY 400
            .|...:.:|::.|.|..:|.|    ||.         |.|.|...||.:.|:::...:    .:|
Zfish   852 QSQEFSKVPLMTGVTDDDGGF----TLP---------EFIAPPGWRDGMTKDQIMPFL----PTY 899

  Fly   401 ---FDDPDRASMELYECLHILSIK------------NFWHDIHRTLLARLAYATNLPTYLYRFDM 450
               ..||..|.:.|.|.|...:.|            :|:.::....||.....|..|.|:|.|..
Zfish   900 NYDLQDPGLAEIVLKEYLGATTDKIKIRDGFREIVGDFFFNLPARKLANYHRDTGAPVYMYEFQH 964

  Fly   451 DSPHFNHYRILKCGKKVRGVCHADDISYMF-----YGILSSKLDKNSPEYRTIERLVGMWTSFAT 510
            .:..|.:.|     ....|..|.|::.::|     .|.:..:.:.:..|....:..:..|.:||.
Zfish   965 PAYIFQNKR-----PSFVGCDHGDELLFVFGYCFGNGHIKVEGELSKEEQELCKTTMAYWGNFAR 1024

  Fly   511 TGDPNCEIIAP--VKWDPLRPGGVENCLNIADGLEFIPLPESKQF 553
            ||:||    .|  |:|.  :.|.....|.|  |||   ...||.|
Zfish  1025 TGNPN----GPGLVEWP--KYGAEAEYLGI--GLE---QKSSKNF 1058

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	174/544 (32%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	55/111 (50%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:306613
		COesterase	553..1065	CDD:306613	182/565 (32%)
		COesterase	1079..1592	CDD:306613
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.820