DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and nlgn4xa

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	XP_021330915.1	Gene:	nlgn4xa / 561122	ZFINID:	ZDB-GENE-100309-2	Length:	844	Species:	Danio rerio

Alignment Length:	614	Identity:	182/614 - (29%)
Similarity:	273/614 - (44%)	Gaps:	156/614 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LATKYGQLKGQQRRTLYDGE---PYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCT------ 90
            :.|.||:|:|  .:|....|   |...:.|||:|.||.||.||:.|:||.||.|:|:.|
Zfish    45 VTTNYGKLRG--LKTPLPNEILGPVEQYLGIPYALPPTGERRFQPPEPPMSWPGIRNATQFAPVC 107

  Fly    91 --YAREKPMQRNS------------ITNAAEGSEDCLYLNVYA---------------------K 120
              :..::.:..:.            :|...:.||||||||:|.                     |
Zfish   108 PQFLEDRFLLNDMLPVWFTANLDTVVTYVQDQSEDCLYLNIYVPTEDVGANKGDDFTNNEGGENK 172

  Fly   121 RLESPKPL-PVMVWIFGGGFQVG------GASRELYGPDYFMKHDILLVTINYRVGVLGFLSLKD 178
            .:.....| ||||:|.||.:..|      |:....||       ::::||:|||:|||||||..|
Zfish   173 DIHDENGLRPVMVYIHGGSYMEGTGNMIDGSILASYG-------NVIVVTLNYRLGVLGFLSTGD 230

  Fly   179 KELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIV 243
            :..|  ||.||.||||||||:||||.:|.|||:.:|:||..||.:...:|..:..:..||.:||:
Zfish   231 QAAK--GNYGLLDQIQALRWIKENIQAFKGDPKRVTIFGSGAGASCVSLLTLSHYSEDLFQKAII 293

  Fly   244 QSGSALCAWAT--QPDRKWPQRLGKELGYAGNLESEKELLEFFQQIPASKL-AQYCNSIVTQEEQ 305
            |||:||.:||.  || .|:.:.|.:::|.  |:....:|:|..|.....:| .||    :||.:
Zfish   294 QSGTALSSWAVNYQP-AKYTRILAEKVGC--NMLDSIDLVECLQNKNYKELIEQY----ITQAK- 350

  Fly   306 RDYEILAFAPVIEPYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSYRTTLDDPLYMLS 370
              |.| ||.|||:   ||  |||...|..:......:..:::|....|| |.:...:.|....:|
Zfish   351 --YHI-AFGPVID---GD--VIPDDPQILMEQGEFLNYDIMLGVNQGEG-FKFVDGIVDSEDGVS 406

  Fly   371 AFEAIIPKQVRDAID--------KEELAEMVRRLKKSYFDDPDRASMEL-YECLHILSIKNFW-- 424
            |.:  ....|.|.:|        |:.|.|.:   |..|.|..|:.:.|. .:.|..|...:.|
Zfish   407 AND--FDFAVSDFVDHLYGYPEGKDTLRETI---KFMYTDWADKENPETRRKTLVALFTDHQWVA 466

  Fly   425 -----HDIHRTLLARLAYATNLPTYLYRFDMDSPHFNHYRILKCGKKVR----GVCHADDISYMF 480
                 .|:|      ..|.:  |||.|.|      ::|     |..:::    ...|.|::.|:|
Zfish   467 PAVATADLH------AQYGS--PTYFYAF------YHH-----CQSEMKPSWSDSAHGDEVPYVF 512

  Fly   481 YGI--------LSSKLDKNSPEYRTIERLVGMWTSFATTGDPNCEIIAPVKWDPLRPGGVENCLN 537
             ||        .:....||......:  ::..||:||.|||||..:....|:...:|...|.
Zfish   513 -GIPMLGPTDLFNCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEE--- 571

  Fly   538 IADGLEFIPLPESKQFVVWDSFYTRESLY 566
                            |.|..:..::.||
Zfish   572 ----------------VAWSKYNPKDQLY 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	177/580 (31%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	52/132 (39%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:306613	182/614 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575657
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740