DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and Ces2h

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001037723.1	Gene:	Ces2h / 498940	RGDID:	1560889	Length:	558	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	161/525 - (30%)
Similarity:	237/525 - (45%)	Gaps:	92/525 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 QLKGQQR----RTLYDGE-------------PYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRD 88
            |::||..    ||.:.|:             ..:||.|||||:||:|.|||..|:.|..|.||||
  Rat    22 QVQGQDSLSPIRTTHTGQILGSLIHMKGLDVGVHSFLGIPFAKPPIGPLRFAPPEAPEPWSGVRD 86

  Fly    89 CTYAREKPMQRNSITN------------AAEGSEDCLYLNVYA-KRLESPKPLPVMVWIFGGGFQ 140
            .|......:|..:..|            ....||||||||:|. ........|||||||.||...
  Rat    87 GTSHPAMCLQDITAMNMQAFKLLKLTLPLIPMSEDCLYLNIYTPNHAHEGSNLPVMVWIHGGALV 151

  Fly   141 VGGASRELY-GPDYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIA 204
            :|.||  || |.......::::|||.||:|||||.|..|:..:  ||.|..||:.||.||::|||
  Rat   152 IGMAS--LYDGSMLAAMENVVVVTIQYRLGVLGFFSTGDQHAR--GNWGYLDQVAALHWVQQNIA 212

  Fly   205 SFNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQRLGKELG 269
            .|.|:|:.:|:|||||||.|....:.:..:|||||.||::||.||.:....        :..::.
  Rat   213 HFGGNPDRVTIFGESAGGTSVSSHVVSPMSRGLFHGAIMESGVALMSSLIS--------VSSDVV 269

  Fly   270 Y--AGNLESEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEILAFAPVIEPYVGDDCVIPKSQQ 332
            |  ..||..       .:|:.:..|.   |.:..:.|:....|.....:|...| |...:|:..:
  Rat   270 YRTVANLSG-------CEQVDSKALV---NCLRGKSEEEIMSINKAFRIISGIV-DGIFLPRHPK 323

  Fly   333 EQLSSAWGNSIPMIIGGTSFEG---LFSYRTTLDDPLYM-LSAFEAIIPKQVRDAIDKEELAEMV 393
            |.|:||..:.||.|||..:.|.   :.|..||.|....| ....:||:.|:|...:...|.::::
  Rat   324 ELLASADFHPIPSIIGVNNDEYGWIIPSSMTTTDSKKKMDRQMVQAILQKRVAQMMWPPEFSDLL 388

  Fly   394 RRLKKSYFDDPDRASMELYECLHILSIKNFWHDIHRTLLARLAYATNLPTYLYRF--------DM 450
            ........:||....::..|.:     ::|...|....:|.. ..:|.|.|.|.|        |.
  Rat   389 LEEYMGDSEDPQFLQVQFKEMM-----EDFTFVIPALQVAHF-QRSNAPVYFYEFQHRPSFFKDS 447

  Fly   451 DSPHFNHYRILKCGKKVRGVCHADDISYM---FYGILSSKLDKNSPEYRTIERLVGMWTSFATTG 512
            ..||..             ..|.|:|.::   |:|  .:::|....|.....|::..|.:||..|
  Rat   448 KPPHVK-------------ADHGDEILFIFRSFWG--GTQVDLTEEEELLSRRMMKYWANFARQG 497

  Fly   513 DPNCE 517
            :||.|
  Rat   498 NPNSE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	161/525 (31%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	49/106 (46%)
Ces2h	NP_001037723.1	COesterase	30..537	CDD:278561	158/517 (31%)
Ces2h	NP_001037723.1	Aes	<127..>230	CDD:223730	49/106 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336454
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640