Protein Alignment gas and ACHE

DIOPT Version :10

• Sequence 1: NP_611678.1
• Gene: gas / 37572
• FlyBaseID: FBgn0034736
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 184/605 - (30%)
• Similarity: 279/605 - (46%)
• Gaps: 100/605 - (16%)

  Fly    27 LGTGQTKE--------LATKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSW 83
            ||.|...|        :..:.|:|:|.:.:|  .|.|..:|.|||||:||:|..||..|:|...|
Human    92 LGGGVGAEGREDAELLVTVRGGRLRGIRLKT--PGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPW 154

  Fly    84 QGVRDCTYAREKPMQR-NSITNAAEG----------SEDCLYLNVYAKRLESPKPLPVMVWIFGG 137
            .||.|.|..:....|. :::....||          |||||||||:........|.||:|||:||
Human   155 SGVVDATTFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGG 219

  Fly   138 GFQVGGASRELYGPDYFMKHD-ILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKE 201
            ||..|.:|.::|...:.::.: .:||::|||||..|||:|.... :.|||.||.||..||:||:|
Human   220 GFYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSR-EAPGNVGLLDQRLALQWVQE 283

  Fly   202 NIASFNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWAT---QPDRKWPQR 263
            |:|:|.|||.|:|:||||||.||..:.:.:..:|||||||::|||:....|||   ...|:...:
Human   284 NVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQ 348

  Fly   264 LGKELGY--AGNLESEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEILAFAPVIEPYVGDDCV 326
            |...:|.  .|...::.||:...:..||..|..:...::.||....:   :|.||::   ||  .
Human   349 LAHLVGCPPGGTGGNDTELVACLRTRPAQVLVNHEWHVLPQESVFRF---SFVPVVD---GD--F 405

  Fly   327 IPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSYRTTLDDP--------LYMLSAFEAIIPKQVRDA 383
            :..:.:..:::...:.:.:::|....||  ||......|        |...:.|.|.:...|...
Human   406 LSDTPEALINAGDFHGLQVLVGVVKDEG--SYFLVYGAPGFSKDNESLISRAEFLAGVRVGVPQV 468

  Fly   384 IDKEELAEMVRRLKKSYFDDPDRASMELYECL-HILSIKNFWHDIHRTLLARLAYATNLPTYLYR 447
            .|....|.::......:.:||.|    |.|.| .::...|....:.: |..||| |.....|.|.
Human   469 SDLAAEAVVLHYTDWLHPEDPAR----LREALSDVVGDHNVVCPVAQ-LAGRLA-AQGARVYAYV 527

  Fly   448 FDMDSPHFNHYRILKCGKKVRGVCHADDISYMFYGILSSKLDKNSPEYRTIERLVGMWTSFATTG 512
            |:       |...........||.|..:|.::|...|....:..:.|....:||:..|.:||.||
Human   528 FE-------HRASTLSWPLWMGVPHGYEIEFIFGIPLDPSRNYTAEEKIFAQRLMRYWANFARTG 585

  Fly   513 DPN--CEIIAPVKWDP------------LRPGGVENCLNIADGL---------EFIP-------- 546
            |||  .:..|| :|.|            |||      |.:..||         .|:|
Human   586 DPNEPRDPKAP-QWPPYTAGAQQYVSLDLRP------LEVRRGLRAQACAFWNRFLPKLLSATDT 643

  Fly   547 LPESKQFVVWDSFYTRESLY 566
            |.|:::  .|.:.:.|.|.|
Human   644 LDEAER--QWKAEFHRWSSY 661

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	31..529	CDD:395084	168/545 (31%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	172/558 (31%)
		AChE_tetra	645..678	CDD:430146	5/19 (26%)