DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and CG10175

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster

Alignment Length:	561	Identity:	206/561 - (36%)
Similarity:	301/561 - (53%)	Gaps:	56/561 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TKYGQLKGQQRRTLYDGE--PYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCTYAREKPMQR 99
            |..|:::|:.:: ...||  .||||:|:.:..||.|..||||.:|...|.|:||.:...:....:
  Fly   158 TSLGKVRGRYQK-YRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCPHK 221

  Fly   100 NSITNAAEGSEDCLYLNVYAKRL-------ESPKPLPVMVWIFGGGFQVGGASRELYGPDYFMKH 157
            |.|.:..:|.||||::||:..::       |.|| ||||||:.||||..|..:..||||||.:..
  Fly   222 NMILDTFKGDEDCLFVNVFTTQMPKDDESAEQPK-LPVMVWLHGGGFSFGSGNSFLYGPDYLVAE 285

  Fly   158 DILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGESAGG 222
            ||:|||:|||:|.||||:...   ..|||.|||||:.||:||::|||:|.|||..:|:||||||.
  Fly   286 DIVLVTLNYRLGPLGFLTAGP---DAPGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAGA 347

  Fly   223 ASTHILMQTEQARGLFHRAIVQSGSALCAW---ATQPDRKWPQRLGKELGYAGNLESEKELLEFF 284
            :|..:|:.:.||:|||||||.||||||..|   |:...|  ..||...|||.|..::| ::|:|.
  Fly   348 SSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQR--AARLAANLGYVGANKTE-DILDFL 409

  Fly   285 QQIPASKLAQYCNSIVTQEEQRDYEILAFAPVIEPYVGDDCVIPKSQQEQL-------------- 335
            :::||.||.:...:.:|.|:||:...|.|.||:|.|...|     ||:||.
  Fly   410 RRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQD-----SQEEQFYEEPFLTQHPSDMY 469

  Fly   336 -SSAWGNSIPMIIGGTSFEGLFSYRTTLDDPLYMLSAFEAIIPKQVRDAIDKEELAEMVRRLKKS 399
             |..:.:.:..:.|..:.|.:...|....:| .:||..|....:.|...::..|..:.|.|..:|
  Fly   470 HSQNFNSDVAYMTGYNTHEAMLFIRRLRKNP-QLLSIIENDFGRLVPQDLNVTESHDRVTREIRS 533

  Fly   400 YFDDPDRASME-LYECLHILSIKNFWHDIHRTLLARLAYATNLPTYLYRFDMDSPHFNHYRILKC 463
            ::.......:| :.|.:.:|:...|...|.||......:. |.|.|:|||..|.....:.|:|
  Fly   534 FYLGSKHVGIESVDEMIALLTDLMFLQGIRRTARNHAKFG-NAPVYMYRFSFDGSLGLYKRML-- 595

  Fly   464 GKKVRGVCHADDISYMF-YGILSSKLDKNSPEYRTIERLVGMWTSFATTGDPNCEIIAPV---KW 524
            |....||||.|::.|:| :|..:..||..|.|.:...|:|.|||:||..|.|..:...|:   ||
  Fly   596 GIPRPGVCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRMVRMWTNFAKYGSPTPDSEDPMLTTKW 660

  Fly   525 DPLRPGGVENCLNIAD-----GLEFIPLPESKQFVVWDSFY 560
            .|:.|..|.|.||..|     .::..|.||.::|  ||..|
  Fly   661 APIDPTNVMNSLNYMDISANLAMKTNPEPERQRF--WDEMY 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	195/528 (37%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	59/111 (53%)
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	203/555 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.760