DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and Nlg3

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001036685.2	Gene:	Nlg3 / 40912	FlyBaseID:	FBgn0083963	Length:	1159	Species:	Drosophila melanogaster

Alignment Length:	612	Identity:	160/612 - (26%)
Similarity:	230/612 - (37%)	Gaps:	193/612 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 DG---EPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDC-----------------TYAREK- 95
            ||   :|..::.|||:|.||||.|||..|...:.|.||:..                 |.|.|:
  Fly   173 DGRHLDPVEAYRGIPYASPPVGNLRFMPPVSAAMWSGVKKADRFSPVCPQRLPDIHNETAALERM 237

  Fly    96 ------------PMQRNSITNAAEGSEDCLYLNVY------------------------------ 118
                        |..:|.       ||||||||:|
  Fly   238 PKGRLEYLKRLLPYLQNQ-------SEDCLYLNIYVPIQVGSRDSSGSSSSSSAGSSSSGSGGSS 295

  Fly   119 -----------AKRLESPKPLPVMVWIFGGGFQ------VGGASRELYGPDYFMKHDILLVTINY 166
                       :....||...||:|::.|..::      ..|:....||       .||:|||||
  Fly   296 SSSSSSSTSSSSAGSGSPAKYPVLVFVHGESYEWNSGNPYDGSVLASYG-------QILVVTINY 353

  Fly   167 RVGVLGFLSLK-DKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGESAGGASTHILMQ 230
            |:||||||:.. |:..|:|.|.||.|.|.||.|:|||||:|.|||.|||:.|...|.|..|.|:.
  Fly   354 RLGVLGFLNANTDRYSKLPANYGLMDIIAALHWLKENIAAFGGDPNSITLAGHGTGAACVHFLIS 418

  Fly   231 TEQA-RG-LFHRAIVQSGSALCAWATQPDRKWPQRLGKELGYAGNLESEKELLEFFQQIPASKLA 293
            :... .| ||:|||:.|||.|..|:...:   |.:....:.:..|..|:         :|.:.|.
  Fly   419 SMAVPEGLLFNRAILMSGSGLAPWSLVSN---PAKYAAIVAHHVNCASD---------LPHAHLM 471

  Fly   294 QYCNSIVTQEEQRDYEI------LAFAPVIEPYV--GDDCVIP------KSQQEQLSSAWGNSI- 343
            : |....|.::.....|      .||.|.|:..|  |.|.|.|      ...|.|.|:|.||.:
  Fly   472 K-CLREKTLDQLLSVPIRPPEFGFAFGPSIDGVVIDGGDYVPPAPGSPAAQAQAQASTAAGNGLG 535

  Fly   344 ----------------------------------PMIIGGTSFEGLFSYRTTLDDPLYMLSA--F 372
                                              .::.|.|..|..||:.:  .|..|.:.|  .
  Fly   536 GEAGIAAAGGWGTPGQLENIVLMRKTAINKLSRYDLMAGVTRAEAFFSFNS--GDVQYGIEADRR 598

  Fly   373 EAIIPKQVRDAIDKEELAEMVRRLKKSYFD------DPDRASMELYECL---HILSIKNFWHDIH 428
            ..|:...||:.. ...|.|:...:...|.|      .|.....|..|.|   .:::......|:|
  Fly   599 SRILKAYVRNTY-TFHLNEIFATIVNEYTDWERPVQHPINIRDETLEALSDAQVVAPAAQTVDLH 662

  Fly   429 RTLLARLAYATNLPTYLYRFDMDSPHFNHYRILKCGKKVRGVCHADDISYMFYGILSSKLDKNSP 493
            .        |.:..:|||.||..: .|..|      .:.:|..|.:|:.|:|...|....:..:.
  Fly   663 S--------ADHRNSYLYVFDYQT-RFGDY------PQRQGCIHGEDLPYIFGAPLVGGFNHFTR 712

  Fly   494 EYRTI-----ERLVGMWTSFATTGDPN 515
            .|...     |.::..|::|..||:||
  Fly   713 NYTKTEISLSEVVMFYWSNFVRTGNPN 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	160/612 (26%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	48/152 (32%)
Nlg3	NP_001036685.2	COesterase	151..791	CDD:278561	160/612 (26%)
Nlg3	NP_001036685.2	Aes	<313..>410	CDD:223730	46/103 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440328
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740