DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and alpha-Est8

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster

Alignment Length:	578	Identity:	268/578 - (46%)
Similarity:	367/578 - (63%)	Gaps:	16/578 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLRVSFSDKLKLGAKIIGHKVVQYKLGTGQTKELATKYGQLKGQQRRTLYDGEPYYSFEGIPFA 65
            |...::.:|::::....:..|..|.:|.:.......|.||::||.:.:::| |..||||||||||
  Fly     1 MSFDIAVADQMRIALNYVKFKTNQQRLRSNDKVIADTVYGKVKGVKWQSIY-GNNYYSFEGIPFA 64

  Fly    66 QPPVGELRFRAPQPPSSWQGVRDCTYAREKPMQRNSITNAAEGSEDCLYLNVYAKRLESPKPLPV 130
            :||||||||:||..|..|..|:.||:.|.||.|.|.:....:|||||||||||.:.|...:||||
  Fly    65 KPPVGELRFKAPVEPEHWSDVKRCTHVRAKPCQVNIVLKQVQGSEDCLYLNVYTRELHPHRPLPV 129

  Fly   131 MVWIFGGGFQVGGASRELYGPDYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQA 195
            :|||:|||||:|.|||:||.|||.|...::||.|:||:|.||||||.|:||.:|||||||||:.|
  Fly   130 LVWIYGGGFQMGEASRDLYSPDYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMA 194

  Fly   196 LRWVKENIASFNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDR-K 259
            |||||.|...|.|||::||||||||||||||.:|.|:||:||||:.|:.|||||..||..|.. .
  Fly   195 LRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHIN 259

  Fly   260 WPQRLGKELGYAGNLESEKELLEFFQQIPASKLAQYCNSIVTQEEQRD-YEILAFAPVIEPYVGD 323
            ||.||.:..||.|: .:::::....::..||.:.:....|:|.||:.. ..:.:|.|.||||:..
  Fly   260 WPYRLAQATGYTGD-ANDRDIFAHLKKCKASSMLKVAEDIITMEERHQRLTMFSFGPTIEPYLTP 323

  Fly   324 DCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSYRTTLDDP--LYMLSAFEAIIPKQVRDAIDK 386
            .||||||..|.:...|||||||:|||.|||||..:......|  |..|...|.:.|:...  :|:
  Fly   324 HCVIPKSPLEMMRDCWGNSIPMVIGGNSFEGLLMFPEVNKWPELLCQLGDCENLAPQDAH--VDE 386

  Fly   387 EELAEMVRRLKKSYFDDPDRASMELYECLHILSIKNFWHDIHRTLLARLAYATNLPTYLYRFDMD 451
            ::.....:::::.||.|.......:.|...:.|.|.|||.||||||:|..:|...||:|||||.|
  Fly   387 QQRKAFGKKVRELYFGDRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFD 451

  Fly   452 SPHFNHYRILKCGKKVRGVCHADDISYMFYGILSSKLDKNSPEYRTIERLVGMWTSFATTGDPNC 516
            |.|||..||:.||:||||.|||||:||:||...:.||.:.:.|::||:|||.|...||.:||||.
  Fly   452 SKHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPNI 516

  Fly   517 EIIAPVK-------WDPL-RPGGVENCLNIADGLEFIPLPESKQFVVWDSFYTRESLY 566
            .::...:       |.|: :...|..||||:..:..|.|||:::..:||..|.||.||
  Fly   517 PMVCQDEKEQPRGAWLPISKDDKVFQCLNISHDVHVIDLPEAEKLRLWDCIYDRELLY 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	248/517 (48%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	68/104 (65%)
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	256/538 (48%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	68/104 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467344
Domainoid	1	1.000	450	1.000	Domainoid score	I1603
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	492	1.000	Inparanoid score	I3113
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26273
OrthoDB	1	1.010	-	-		D18817at7147
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	11	10.910