DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and Ces3a

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_941074.1	Gene:	Ces3a / 382053	MGIID:	102773	Length:	571	Species:	Mus musculus

Alignment Length:	582	Identity:	171/582 - (29%)
Similarity:	254/582 - (43%)	Gaps:	133/582 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IIGHKVVQYKLGTGQTKELATKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPS 81
            :||.||.|        .|:.|..|:::|:|............|.||||||.|:|.|||.||.||.
Mouse    29 VIGPKVTQ--------PEVDTPLGRVRGRQVGVKDTDRMVNVFLGIPFAQAPLGPLRFSAPLPPQ 85

  Fly    82 SWQGVRDCTYAREKPMQRNSITNAAEG-------------SEDCLYLNVYAKRLESPKPL----- 128
            .|:||||.:.  ..||....:...:..             |||||.||:|     ||..:
Mouse    86 PWEGVRDASI--NPPMCLQDVERMSNSRFTLNEKMKIFPISEDCLTLNIY-----SPTEITAGDK 143

  Fly   129 -PVMVWIFGGGFQVG------GASRELYGPDYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGN 186
             ||||||.||...||      |::...||       |:::||:.||:|:.||||..||.:  |||
Mouse   144 RPVMVWIHGGSLLVGSSTSHDGSALAAYG-------DVVVVTVQYRLGIFGFLSTGDKHM--PGN 199

  Fly   187 AGLKDQIQALRWVKENIASFNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCA 251
            .|..|.:.|||||:.|||.|.|||..:|:||.||||.....|:.:..:.|||||||.||| .:.:
Mouse   200 RGFLDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGIIVSSLLLSPMSAGLFHRAISQSG-VVIS 263

  Fly   252 WATQPDRKWPQRLGKELGYAGNLESEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEILAFAPV 316
            ...:....|.:........|....|..||::             |   :.|:|.:|  ::....|
Mouse   264 KILEDLNAWSEAQNFANSVACGSASPAELVQ-------------C---LLQKEGKD--LITKKNV 310

  Fly   317 IEPYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSYRTTLDDPLYMLSAFEAIIPKQVR 381
            ...|..:|...|:..|:.|::....::|.::|.|:.|  |.         ::|..|..|:.|.
Mouse   311 NISYTVNDSFFPQRPQKLLANKQFPTVPYLLGVTNHE--FG---------WLLLKFWNILDKM-- 362

  Fly   382 DAIDKEELAEMVRRLK--------------KSYFDDPDRASMELYECLHILSIKNFWHDIHRTLL 432
            :.:.:|:|.|..|.|.              ..|.|:....|...|....:|.      || ..::
Mouse   363 EHLSQEDLLENSRPLLAHMQLPPEIMPTVIDEYLDNGSDESATRYALQELLG------DI-TLVI 420

  Fly   433 ARLAYATNL-----PTYLYRFDMDSPHFNHYR--ILKCGKKVRGVCHADDISYMFYGILSSKLDK 490
            ..|.::..|     |.:||.|......|..::  .:|..       |:.:.:::|.|...:  |:
Mouse   421 PTLIFSKYLQDAGCPVFLYEFQHTPSSFAKFKPAWVKAD-------HSSENAFVFGGPFLT--DE 476

  Fly   491 NS----PEYRTIER-----LVGMWTSFATTGDPNCEIIAPVKWDPLRPGGVENCLNIADGLE 543
            :|    ||....|:     ::..|:.||.||:||.:.:.|  |..|..  :|..|.|  |||
Mouse   477 SSLLAFPEATEEEKQLSLTMMAQWSQFARTGNPNGKGLPP--WPQLNQ--LEQYLEI--GLE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	160/560 (29%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	50/116 (43%)
Ces3a	NP_941074.1	COesterase	36..547	CDD:278561	167/575 (29%)
		Aes	75..>245	CDD:223730	74/185 (40%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832503
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740