DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and Ces1b

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001074841.1	Gene:	Ces1b / 382044	MGIID:	3779470	Length:	567	Species:	Mus musculus

Alignment Length:	563	Identity:	164/563 - (29%)
Similarity:	245/563 - (43%)	Gaps:	128/563 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IIGHKVVQYKLGTGQTKELATKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPS 81
            |.||......:.|.|.|.|. ||..|:|.:       .|...|.|:|||:||:|.|||..|:|..
Mouse    16 IWGHSPSSPVVDTTQGKILG-KYTSLEGFE-------HPVAVFLGVPFAKPPLGSLRFAPPEPAE 72

  Fly    82 SWQGVRDCTY--------AREKPMQRNSITNAAEG-----SEDCLYLNVYAKR-LESPKPLPVMV 132
            .|..|::.|.        |....:..:.::...|.     ||||||||:|:.. |.....|||||
Mouse    73 PWSFVKNATSYPPMCSQDAVAVQLLSDMLSTKKESIPPLFSEDCLYLNIYSPADLTKSSLLPVMV 137

  Fly   133 WIFGGGFQVGGASRELYGPDYFMKHD-ILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQAL 196
            ||.|||...||||  ||.......|: :::|||.||:|:.|..|..|:..:  ||....||:.||
Mouse   138 WIHGGGLMTGGAS--LYNGLALSAHENVVVVTIQYRLGIWGLFSTGDEHSR--GNWAHLDQLAAL 198

  Fly   197 RWVKENIASFNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSAL-----------C 250
            |||::|||:|.|:|:|:||||.||||.|..:|:.:..|:.||||||.:|...|           |
Mouse   199 RWVQDNIANFGGNPDSVTVFGSSAGGVSVSVLVLSPLAKNLFHRAISESSVVLENIVITLDLVAC 263

  Fly   251 AWATQPDRKWPQRLGKELG----------YAGNLESEKELLEFFQQIPASKLAQYCNSIVTQEEQ 305
            ..:        |.:....|          .....::|.||||...::..:|:....::      :
Mouse   264 DLS--------QMIATVSGCNDTSSTAMVQCLRQKTENELLEITVKLEVTKVGGAASA------K 314

  Fly   306 RDYEILAFAPVIEPYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSYRTTLDDPLYMLS 370
            :|.  .:.:.||     |..|:||:.:|.|:....:::|.|:|....|
Mouse   315 KDN--TSMSTVI-----DGVVLPKAPEEILAEKSFSTVPYIVGFNKQE----------------- 355

  Fly   371 AFEAIIPKQVRDAIDK----EELAEMVRR---------------LKKSYF---DDPDRASMELYE 413
             |..|||..:.|.:.:    ||.|.::.|               :.:.|.   |||.:....|.:
Mouse   356 -FGWIIPTMLGDLLSEGKMNEETASLLLRRFHSDLNISESLIPAVIEKYLRGTDDPAKKRDLLLD 419

  Fly   414 CLHILSIKNFWHDIHRTLLARLAYATNLPTYLYRFDMDSPHFNHYRIL----KCGKKVRGVCHAD 474
                 ...:.:..|...||:|......:.||:|.|        .||..    |..:.|.| .|.|
Mouse   420 -----MFSDVFFGIPAVLLSRSLRDAGVSTYMYEF--------RYRPSFVSDKRPQTVEG-DHGD 470

  Fly   475 DISYMFYGILSSKLDKNSPEYRTIERLVGMWTSFATTGDPNCE 517
            :| :..:||...|...:..|....:.::..|.:||..|:||.|
Mouse   471 EI-FSVFGIPLLKEGTSEEETNLSKMVMKFWANFARNGNPNGE 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	161/552 (29%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	50/106 (47%)
Ces1b	NP_001074841.1	COesterase	19..547	CDD:278561	162/560 (29%)
Ces1b	NP_001074841.1	Aes	<121..>239	CDD:223730	55/121 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832600
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650