DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and Jhedup

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	168/545 - (30%)
Similarity:	259/545 - (47%)	Gaps:	81/545 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 GQQRRTL---YDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCTYAREKPMQRNSITN- 104
            |..|.||   |....:.:|.||||||||||.||.:.|.|...|:||.|...|::..:||:....
  Fly    28 GCMRGTLMPGYQSGEFEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSCIQRSYFAKE 92

  Fly   105 -AAEGSEDCLYLNVYAKRLESPKPLPVMVWIFGGGFQVGGASRELYGPDYFM-KHDILLVTINYR 167
             ...|.|||||||||..:..:...|||||:|.||||..|.|.....||:|.| .:.:::||:|||
  Fly    93 WGLMGVEDCLYLNVYRPKNRAEDKLPVMVYIHGGGFFSGSAHPMASGPEYLMDTNKVVMVTMNYR 157

  Fly   168 VGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGESAGGASTHILMQTE 232
            :|..||||..|:.:  |||.|.|||..||:|::::||:|.|||:.:||.|.||||.|.|:.|.:.
  Fly   158 LGPFGFLSTGDEHM--PGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHSAGGISAHLHMISP 220

  Fly   233 QARGLFHRAIVQSGSA-LCAWATQPD-RKWPQRLGKELG--YAGNLESEKELLEFFQQIPASKLA 293
            .::|||..::..:|:. |.|.....| ....:||||||.  .|.:|.|: :|.|..:.:...||.
  Fly   221 NSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQAESLSSQ-DLAEALRNVCPKKLL 284

  Fly   294 QYCNSIVTQEEQRDYEILAFAPVIEPYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSY 358
            ...:|:...:....   |...||:|. ...|..:.:...:...:...|.:|.|:..:|..|
  Fly   285 VSVDSLKVWDNMPH---LTTLPVLEA-PSPDAFLVEDPLDAHRAGRINQMPWILSLSSRAG---- 341

  Fly   359 RTTLDDPLYMLSAFEAIIPKQVRDAIDK---EELA-----------EMVRRLKKSY-FDDPDRAS 408
                :..|:::.||  |.|| :|...::   |.:|           :||..:..:| |......:
  Fly   342 ----EGSLFIMRAF--INPK-LRAEFNENFLEHMALLLNLPEGTPVQMVSEILDAYDFKGDSLNN 399

  Fly   409 MELYECLHILSIKNFWHDIHRTLLARLAYATNL---PTYLYRFDMDSPH---------FNHYRIL 461
            ..:.:...|....||::.|:.|:.:.:.|| ||   |.::|.|:....:         .:.|.:
  Fly   400 DTMLKLAEISGDFNFYYPIYETISSYVTYA-NLEENPLFIYIFEFAGLNSITKFFAGTTDDYGL- 462

  Fly   462 KCGKKVRGVCHADD--------ISYMFYGILSSKLDKNSPEYRTIERLVGMWTSFATTGDPNCEI 518
                   |..|.||        :|:       ....|:|.:.:.|:|:..:.|.||.||..:.|.
  Fly   463 -------GAVHMDDGLHTIRIPVSF-------DDFPKDSEDAKVIQRMSSLMTDFAKTGVFHEES 513

  Fly   519 IAPVKWDPLRPGGVENCLNIADGLE 543
            |..|  ...:..|:.|.|:.....|
  Fly   514 ICKV--SDFKEQGMCNYLHFGGNKE 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	165/534 (31%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	50/105 (48%)
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	159/510 (31%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	50/105 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440391
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	9	8.800