DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and Gli

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster

Alignment Length:	580	Identity:	172/580 - (29%)
Similarity:	235/580 - (40%)	Gaps:	164/580 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LATKYGQLKGQQRRTLYDG-------EPYYS-----------FEGIPFAQPPVGELRFRAPQPPS 81
            :.|.|||::| .:..:||.       .||:|           |.|||:|.||..|.||:.|:...
  Fly   137 VTTNYGQVQG-FKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHR 200

  Fly    82 SWQGVRDCTYAREKPMQRNSITNAAEG----SEDCLYLNVYAKRLESPK-------PLPVMVWIF 135
            .||.::...:....| |....|.|.:|    .|||||||||     |||       ..||||:|.
  Fly   201 GWQLLQAVDFGPACP-QPVRYTGATKGIMDMDEDCLYLNVY-----SPKTGAGVAQKYPVMVYIH 259

  Fly   136 GGGFQVGGASRELYGPDYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVK 200
            ||.| :.|||....|......:|:::||:|||:|.|||||..|:  ..|||.|:.||..|||||.
  Fly   260 GGEF-IRGASNLFQGHILASFYDVVVVTLNYRLGALGFLSTGDE--NSPGNYGILDQAMALRWVY 321

  Fly   201 ENIASFNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQRLG 265
            :||..||||..|||:||..|||||..:||...|.|.:..|.|.||||||..||...|:...|...
  Fly   322 DNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTS 386

  Fly   266 KELG--YAGNLESEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEILAFAPVIEPYVGDDCVIP 328
            :.||  ...::||..:|:               |.:.|   .|.:..|..|. ..|.||
  Fly   387 RVLGQLLGCSIESSWKLV---------------NCLRT---GRSFYELGNAE-FSPQVG------ 426

  Fly   329 KSQQEQLSSAWGN------SIPMIIGGTSFEGL----FSYRTTLDDPLYMLSAFEAIIPKQVRDA 383
                   |..||.      ::|   |...:||.    :.:.|...:.|.....|...|  |....
  Fly   427 -------SFPWGPVLDHNFTLP---GDDWYEGWREKDWRFLTQTPETLIRAGKFNRNI--QYMTG 479

  Fly   384 IDKEELAEMVRR---------LKKSYFDDPDRASM----------ELYECLHILSIKNFWHDIHR 429
            :..:|.|..|.:         |...:||...|..:          .:||.  |..|..||.|.:.
  Fly   480 VTTQEAAFFVAQNESLSPYYELDGRFFDQKIREHVFRYNYTLNPNGVYEA--IKYIYTFWPDPNN 542

  Fly   430 TLLARLAYATNLPTYLYRFDMDSPHFNHYRILKCGKKVRGVCHADDISYMFYGILSSKLDK-NSP 493
            ..:.|..|...|....||..:|             :.|:.:.......||:  :|::.::. |.|
  Fly   543 NTIIRDQYINMLSDLYYRAPVD-------------QMVKLMLEQKVPVYMY--VLNTTVEALNLP 592

  Fly   494 EYR----TIER--LVG------------------MW---------------TSFATTGDP 514
            ::|    .|||  |.|                  ||               |:||..|:|
  Fly   593 QWRKYPHDIERYFLTGAPFMDTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNP 652

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	172/580 (30%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	53/111 (48%)
Gli	NP_476602.1	COesterase	134..695	CDD:278561	172/580 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440426
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.740