DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and Ces1e

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_113753.2	Gene:	Ces1e / 29225	RGDID:	621508	Length:	561	Species:	Rattus norvegicus

Alignment Length:	556	Identity:	168/556 - (30%)
Similarity:	246/556 - (44%)	Gaps:	124/556 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 GHKVVQYKLGTGQTKELATKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSW 83
            ||......:.|.|.|.|. ||..|:|..       :|...|.|:|||:||:|.|||..|||...|
  Rat    18 GHPSSLPVVDTLQGKVLG-KYVSLEGFT-------QPVAVFLGVPFAKPPLGSLRFAPPQPAEPW 74

  Fly    84 QGVRDCT----YAREKPMQ----RNSITNAAEG-----SEDCLYLNVYAKR-LESPKPLPVMVWI 134
            ..|::.|    ...:.|:.    .:.:||..|.     ||||||||:|... |.....|||||||
  Rat    75 SFVKNTTSYPPMCSQDPVAGQIVNDLLTNREENISLQFSEDCLYLNIYTPADLTKRDRLPVMVWI 139

  Fly   135 FGGGFQVGGASRELYGPDYFMKHD-ILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRW 198
            .|||..:||||  .|.......|: :::|.|.||:|:.||.|..|:..:  ||.|..||:.||.|
  Rat   140 HGGGLVLGGAS--TYDGLALSTHENVVVVVIQYRLGIWGFFSTGDEHSR--GNWGHLDQVAALHW 200

  Fly   199 VKENIASFNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQR 263
            |::||.:|.|||.|:|:|||||||.|..:|:.:..|:.|||:||.:||.||.|...   :|..:.
  Rat   201 VQDNIDNFGGDPGSVTIFGESAGGESVSVLVLSPLAKNLFHKAISESGVALTAGLV---KKNTRP 262

  Fly   264 LGKELGYAGNLES--------------EKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEILAFA 314
            |.:::......:|              |:||||...::....|..:.:|      ::.|..:
  Rat   263 LAEKIAVVSGCKSTTSAAMVHCLRQKTEEELLETTLKLNLFSLDLHGDS------RQSYPFV--- 318

  Fly   315 PVIEPYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSYRTTLD--------DPL----- 366
                |.|.|..|:||..:|.|:....|::|.|:|....|..:...|.::        ||:
  Rat   319 ----PTVLDGVVLPKMPEEILAEKDFNTVPYIVGINKQEFGWILPTMMNYPPSDMKLDPMTATSL 379

  Fly   367 -----YMLSAFEAIIPKQVRDAIDKEELAEMVRRLKKSYFDDPDRASMELYECLHILSIKNFWHD 426
                 ::|:..|..||..|...:              .:.|||||...:|.|.:         .|
  Rat   380 LKKSSFLLNLPEEAIPVAVEKYL--------------RHTDDPDRNKDQLLELI---------GD 421

  Fly   427 I------------HRTLLARLAYATNLPTYLYRFDMDSPHFNHYRILKCGKKVRGVCHADDISYM 479
            :            ||...||        ||:|.|.. .|.|:..  :|....|..  |.|:| |.
  Rat   422 VIFGVPSVIVSRGHRDAGAR--------TYMYEFQY-RPSFSSK--MKPSTVVGD--HGDEI-YS 472

  Fly   480 FYGILSSKLDKNSPEYRTIERLVGMWTSFATTGDPN 515
            .:|....:...:..|....:.::..|.:||..|:||
  Rat   473 VFGAPILRGGTSKEEINLSKMMMKFWANFARNGNPN 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	166/547 (30%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	49/106 (46%)
Ces1e	NP_113753.2	COesterase	24..545	CDD:278561	166/550 (30%)
		Aes	43..>239	CDD:223730	84/206 (41%)
		Prevents secretion from ER (Potential)	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810