DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and Ces2g

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001099645.1	Gene:	Ces2g / 291952	RGDID:	1308358	Length:	560	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	159/545 - (29%)
Similarity:	243/545 - (44%)	Gaps:	146/545 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCTYAREKPMQRN- 100
            |..||::|:...:.......::|.|||||:.|||.|||..|:.|..|.||||.|      .|.|
  Rat    38 THTGQVQGKLTHSKDFKSGVHTFLGIPFAKAPVGPLRFAPPEAPEPWSGVRDGT------SQSNI 96

  Fly   101 ---SITNAAEG-------------SEDCLYLNVYA-KRLESPKPLPVMVWIFGGGFQVGGASREL 148
               ::....||             ||||||||:|| ........|||||||.||...||.||  :
  Rat    97 CPQNVRMNMEGLKEMKLTLPPVSMSEDCLYLNIYAPAHAHEGSHLPVMVWIHGGALTVGMAS--M 159

  Fly   149 Y-GPDYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPES 212
            | |.......|:::|||.||:|||||.|..|...:  ||.|..||:.|||||::|||.|.|:|:.
  Rat   160 YDGSMLAATEDVVVVTIQYRLGVLGFFSTGDHHAR--GNWGYLDQVAALRWVQQNIAHFGGNPDC 222

  Fly   213 ITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQRLGKELGYAGNLESE 277
            :|:|||||||.|....:.:..::|||||||::||.||                    ..|.:.:.
  Rat   223 VTIFGESAGGLSVSSHVVSPMSKGLFHRAIMESGVAL--------------------MPGTIFNF 267

  Fly   278 KELLEFFQQI----------PASKLAQYCNSIVTQEE----QRDYEILAFAPVIEPYVGDDCVIP 328
            .|::  :|.:          |.|.:  :|....::|:    .::::::       |.|.|...:|
  Rat   268 SEMV--YQMVVKLSGCEAMDPESLV--HCLRGKSEEQITVISKEFQMI-------PAVVDGEFLP 321

  Fly   329 KSQQEQLSSAWGNSIPMIIG---------------------GTSFEGLFSYRTTLDDPLYMLSAF 372
            ...||.|:||..:.:|.|||                     |.:.|.|.::   |.|     :|.
  Rat   322 NHPQELLASADFHPVPSIIGFNNDEYGWIVPKVIGSAQTIKGITRENLQAF---LKD-----TAP 378

  Fly   373 EAIIPKQVRDAIDKEELAEMVRRLKKSYFDDPDRASMELYECLHILSIKNFWHDIHRTLLARLAY 437
            :.::|.:..|.:.:|.:.::         :||.....:..|.:     ::|...|....:||. .
  Rat   379 QMMLPPECSDLLMEEYMGDI---------EDPQTLQAQFTEMM-----EDFMFVIPSLQVARF-Q 428

  Fly   438 ATNLPTYLYRF--------DMDSPHFNHYRILKCGKKVRGVCHADDISYM----FYGILSSKLDK 490
            .::.|.|.|.|        |:..||..             ..|.|::.::    |:|:   ||:.
  Rat   429 RSHAPVYFYEFQHQSSFLKDIRPPHVK-------------ADHGDEVPFVFGSFFWGM---KLNL 477

  Fly   491 NSPEYRTIERLVGMWTSFATTGDPN 515
            ...|.....|::..|.:||..|:||
  Rat   478 TEGEKLLNRRMMKYWANFARYGNPN 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	159/545 (29%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	52/106 (49%)
Ces2g	NP_001099645.1	COesterase	31..539	CDD:278561	159/545 (29%)
Ces2g	NP_001099645.1	Aes	<129..>232	CDD:223730	52/106 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336285
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640