Protein Alignment gas and CES4A

DIOPT Version :9

• Sequence 1: NP_611678.1
• Gene: gas / 37572
• FlyBaseID: FBgn0034736
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 579
• Identity: 177/579 - (30%)
• Similarity: 270/579 - (46%)
• Gaps: 124/579 - (21%)

  Fly    22 VVQYKLGTGQTK--ELATKYGQLKGQQRRTLYDGE-PYYSFEGIPFAQPPVGELRFRAPQPPSSW 83
            :.|..||...||  ::.||||.|:|:|   ::.|: |...|.|:||::||:|.|||..|:||..|
Human    37 MAQTALGALHTKRPQVVTKYGTLQGKQ---MHVGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPW 98

  Fly    84 QGVRDCT----------------YAREKPMQRNSITNAA-------------------------- 106
            :|:||.|                .||    .|.:.|:|:
Human    99 KGIRDATTYPPGWSLALSPGWSAVAR----SRLTATSASRVQASLLPQPLSIWGYRCLQESWGQL 159

  Fly   107 --------------EGSEDCLYLNVYA-KRLESPKPLPVMVWIFGGGFQVGGASRELYGPDYFMK 156
                          ..||||||||||| .|......||||||..||.|.||.|| ...|.|...:
Human   160 ASMYVSTRERYKWLRFSEDCLYLNVYAPARAPGDPQLPVMVWFPGGAFIVGAAS-SYEGSDLAAR 223

  Fly   157 HDILLVTINYRVGVLGFLSLKDK--ELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGES 219
            ..::||.:.:|:|:.|||..:.:  :....||.||.||:.|||||:||||:|.|||.::|:||:|
Human   224 EKVVLVFLQHRLGIFGFLRWRGRTDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQS 288

  Fly   220 AGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQRLGKELGY-AG-NLESEKELLE 282
            ||..|...||.:..|.|||||||.|||:||.......:   |.::.|::.: || |..|.:.|:.
Human   289 AGAMSISGLMMSPLASGLFHRAISQSGTALFRLFITSN---PLKVAKKVAHLAGCNHNSTQILVN 350

  Fly   283 FFQQIPASKLAQYCNSI--VTQEEQRDYE--ILAFAPVIEPYVGDDCVIPKSQQEQLSSAWGNSI 343
            ..:.:..:|:.:..|.:  :....|||.|  |.:.:||:     |..|||......|:....:|:
Human   351 CLRALSGTKVMRVSNKMRFLQLNFQRDPEEIIWSMSPVV-----DGVVIPDDPLVLLTQGKVSSV 410

  Fly   344 PMIIG--GTSFEGLFSYRTTLDDPLYMLSAFEAIIPKQVRDA-----IDKEELAEMVRRLKKSYF 401
            |.::|  ...|..|..|  .:..||...:..:..|.|.:...     |.||::..:|    :.|.
Human   411 PYLLGVNNLEFNWLLPY--IMKFPLNRQAMRKETITKMLWSTRTLLNITKEQVPLVV----EEYL 469

  Fly   402 DDPDRASMELYECLHILSIKNFWHDIHRTLLARLAYAT----------NLPTYLYRFDMDSPHFN 456
            |:.:....::        ::|...||.:.  |...|||          .||.|||.|:      :
Human   470 DNVNEHDWKM--------LRNRMMDIVQD--ATFVYATLQTAHYHRDAGLPVYLYEFE------H 518

  Fly   457 HYRILKCGKKVRGVCHADDISYMFYGILSSKLDKNSPEYRTIERLVGMWTSFATTGDPN 515
            |.|.:....:..|..|.|::.::|.|..::.|.....:..::: ::..|.:||.||:||
Human   519 HARGIIVKPRTDGADHGDEMYFLFGGPFATGLSMGKEKALSLQ-MMKYWANFARTGNPN 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	175/573 (31%)
		Aes	<117..>222	CDD:223730	50/107 (47%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	174/570 (31%)
		Aes	<184..>291	CDD:223730	50/107 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142748
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.700