DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and Ces2a

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	163/519 - (31%)
Similarity:	231/519 - (44%)	Gaps:	90/519 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 TKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCTYAREKPMQRNS 101
            |..||::|............::|.|||||:||||.|||..|:.|..|.||||.|......:|.:.
  Rat    36 THTGQVRGSFVHVKDTKSGIHTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTDI 100

  Fly   102 I-----------TNAAEGSEDCLYLNVYA-KRLESPKPLPVMVWIFGGGFQVGGASRELYGPDYF 154
            :           .:....||||||||:|. ........|||||||.|||..:|.||.. ......
  Rat   101 MNLDGIKEMKLTVHPTPMSEDCLYLNIYTPAHAREGSNLPVMVWIHGGGLVLGSASMN-DASTLA 164

  Fly   155 MKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGES 219
            ...:|::|:|.||:|||||.|..|:..:  ||.|..||:.|||||::|||.|.|:...:|:||.|
  Rat   165 ATEEIVIVSIQYRLGVLGFFSTGDQNAR--GNWGYLDQVAALRWVQQNIAYFGGNHGKVTIFGGS 227

  Fly   220 AGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQRLGKELGYAGNLESEKELLEFF 284
            |||.|....:.:..::||||.||:|||.||.     ||                |.|:|..:.:.
  Rat   228 AGGTSVSSHVVSPMSKGLFHGAIMQSGVALL-----PD----------------LISDKSEVVYK 271

  Fly   285 Q-------QIPASKLAQYCNSIVTQEEQRDYEILAFAPVIE--PYVGDDCVIPKSQQEQLSSAWG 340
            .       :.|.|:....|....:::     ||||...|.:  |.|.|...:||..||.|:|...
  Rat   272 TVANLSGCEAPDSEALIRCLRAKSKQ-----EILAINQVFKMIPGVVDGKFLPKHPQELLASGDF 331

  Fly   341 NSIPMIIGGTSFE---GLFSYRTTLDDPLYMLSAFEAIIPKQVRDAID---KEELAEM------V 393
            :.:|.|||..:.|   |:         |:::  ..:.||.|..|:.:.   |...|:|      :
  Rat   332 HPVPSIIGINTDECGWGI---------PVFL--GLDHIIKKITRETLPTVLKSTAAQMMLPPECI 385

  Fly   394 RRLKKSYFDDPDRASMELYECLHILSIKNFWHDIHRTLLARLAYATNLPTYLYRFDMDSPHFNHY 458
            ..:.:.|..|.:.......:..|:|.  :|...|....:|.. ..:..|.|.|.| ...|.|.
  Rat   386 DLIMEEYMGDTENPETLQEQFRHMLG--DFMFVIPALQVAHF-QRSQAPVYFYEF-QHLPSFI-- 444

  Fly   459 RILKCGKKVR----GVCHADDISYMFYGIL-SSKLDKNSPEYRTIERLVGMWTSFATTGDPNCE 517
                  |:||    ...|.|||.::|...| ....|....|.....|::..|.:||.||:||.|
  Rat   445 ------KQVRPSHVKADHGDDILFVFGSYLWGMTFDLTEEEELLKRRVMKYWANFARTGNPNGE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	163/519 (31%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	46/105 (44%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	163/519 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336217
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840