DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and Cel

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_058693.2	Gene:	Cel / 24254	RGDID:	2331	Length:	612	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	170/551 - (30%)
Similarity:	258/551 - (46%)	Gaps:	112/551 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KLGTGQTKELATKYGQLKGQQRR-TLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDC 89
            |||.     :.|:.|.::|..:: :|..|:....|:|||||.....|    .||....|||....
  Rat    22 KLGA-----VYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKTLE----NPQRHPGWQGTLKA 77

  Fly    90 TYAREKPMQRNSITNAAEGSEDCLYLNVYAK--RLESPKPLPVMVWIFGGGFQVG---GAS---R 146
            |..:::.:|.....:...|.|||||||::..  |.:....|||||||:||.|.:|   ||:   .
  Rat    78 TDFKKRCLQATITQDDTYGQEDCLYLNIWVPQGRKQVSHDLPVMVWIYGGAFLMGSGQGANFLKN 142

  Fly   147 ELY-GPDYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDP 210
            .|| |.:...:.::::||.|||||.|||||..|..|  |||.||:||..|:.|||.|||:|.|||
  Rat   143 YLYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANL--PGNFGLRDQHMAIAWVKRNIAAFGGDP 205

  Fly   211 ESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRK-WPQRLGKELG----- 269
            ::||:||||||.||..:...:...:||..|||.|||.||..||.|.:.. |.:.:.|::|
  Rat   206 DNITIFGESAGAASVSLQTLSPYNKGLIRRAISQSGVALSPWAIQENPLFWAKTIAKKVGCPTED 270

  Fly   270 ---YAGNLE-SEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEI---LAFAPVIE-PYVGDDCV 326
               .||.|: ::...|....::|.              :.::|.|   |||.||:: .::.||.:
  Rat   271 TAKMAGCLKITDPRALTLAYRLPL--------------KSQEYPIVHYLAFIPVVDGDFIPDDPI 321

  Fly   327 IPKSQQEQLSSAWGNS--IPMIIGGTSFEG-LFSYRTTLDDPLYMLSAFEAIIPKQVRDAIDKEE 388
                      :.:.|:  |..:.|....:| ||:   |:|.|         .|.|..:| :.:|:
  Rat   322 ----------NLYDNAADIDYLAGINDMDGHLFA---TVDVP---------AIDKAKQD-VTEED 363

  Fly   389 LAEMV------RRLK----------KSYFDDPDRASMELYECLHILSIKNFWHDI------HRTL 431
            ...:|      :.||          :|:..||.:.:|:       .::..|..||      ...|
  Rat   364 FYRLVSGHTVAKGLKGTQATFDIYTESWAQDPSQENMK-------KTVVAFETDILFLIPTEMAL 421

  Fly   432 LARLAYATNLPTYLYRFDMDSPHFNHYRILKCGKKVRGVCHADDISYMFYGILSSKLDKNSPEYR 496
            ....|:|.:..||.|.       |:|...:....|..|..||||:.|:|....::.|...:.:..
  Rat   422 AQHRAHAKSAKTYSYL-------FSHPSRMPIYPKWMGADHADDLQYVFGKPFATPLGYRAQDRT 479

  Fly   497 TIERLVGMWTSFATTGDPNC-EIIAPVKWDP 526
            ..:.::..||:||.:||||. ....|..|.|
  Rat   480 VSKAMIAYWTNFAKSGDPNMGNSPVPTHWYP 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	168/549 (31%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	56/113 (50%)
Cel	NP_058693.2	COesterase	26..542	CDD:278561	167/542 (31%)
		Aes	<118..>247	CDD:223730	68/130 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..612
		4 X 11 AA tandem repeats, O-glycosylated region	556..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336388
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.640