Protein Alignment gas and CES3

DIOPT Version :9

• Sequence 1: NP_611678.1
• Gene: gas / 37572
• FlyBaseID: FBgn0034736
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_079198.2
• Gene: CES3 / 23491
• HGNCID: 1865
• Length: 571
• Species: Homo sapiens
• Alignment Length: 609
• Identity: 175/609 - (28%)
• Similarity: 255/609 - (41%)
• Gaps: 146/609 - (23%)

  Fly    15 AKIIGHKVVQYKLGTGQTKELATKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQP 79
            |...|.:|.|        .|:.|..|:::|:|............|.||||||||:|..||.||.|
Human    24 ATATGPEVAQ--------PEVDTTLGRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPHP 80

  Fly    80 PSSWQGVRDCTYAREKPMQ----RNSITNAAEG-------SEDCLYLNVYAKRLESPKPL----- 128
            ...|:||||.:.|....:|    .||......|       |||||.||||     ||..:
Human    81 AQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIFSVSEDCLVLNVY-----SPAEVPAGSG 140

  Fly   129 -PVMVWIFGGGFQVG------GASRELYGPDYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGN 186
             |||||:.||....|      |::...||       |:::||:.||:|||||.|..|:.  .|||
Human   141 RPVMVWVHGGALITGAATSYDGSALAAYG-------DVVVVTVQYRLGVLGFFSTGDEH--APGN 196

  Fly   187 AGLKDQIQALRWVKENIASFNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCA 251
            .|..|.:.|||||:||||.|.||...:||||.||||:....|:.:..|.|||||||.|||.
Human   197 QGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSIISGLVLSPVAAGLFHRAITQSGV---- 257

  Fly   252 WATQP----DRKWP--QRLGKELGYAGNLESEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEI 310
             .|.|    ...||  |::...|  |.:..|..|:::..||....:|       |..::.::
Human   258 -ITTPGIIDSHPWPLAQKIANTL--ACSSSSPAEMVQCLQQKEGEEL-------VLSKKLKN--- 309

  Fly   311 LAFAPVIEPYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSYRTTLDDPLYMLSAFEAI 375
                 .|.|...|..|.|||.:|.|.....:|:|.::|..:.|                  |..:
Human   310 -----TIYPLTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHE------------------FSWL 351

  Fly   376 IPK-----QVRDAIDKEELAEMVRRLKKSYFDDPDRASMELYECL--------HILSIKNFWHDI 427
            ||:     ...:.:.:|::..:...:..|....|:.....:.|.|        ...:.:.|..|:
Human   352 IPRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTVIDEYLGSNSDAQAKCQAFQEFMGDV 416

  Fly   428 HRTL----LARLAYATNLPTYLYRFDMDSPHFNHYRILKCGKKVRGVC----HADDISYMFYGIL 484
            ...:    .:|....:..|.:.|.|......|         .|::...    |..:.:::|.|
Human   417 FINVPTVSFSRYLRDSGSPVFFYEFQHRPSSF---------AKIKPAWVKADHGAEGAFVFGG-- 470

  Fly   485 SSKLDKNS----PEYRTIER-----LVGMWTSFATTGDPNCEIIAPVKWDPLRPGGVENCLNIAD 540
            ...:|::|    ||....|:     ::..||.||.|||||.:.:.|  |..         .|.|:
Human   471 PFLMDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGDPNSKALPP--WPQ---------FNQAE 524

  Fly   541 G-LEFIPLPESKQFV--VWDSFYT 561
            . ||..|:|.:.|..  .|..|::
Human   525 QYLEINPVPRAGQKFREAWMQFWS 548

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	162/564 (29%)
		Aes	<117..>222	CDD:223730	50/116 (43%)
CES3	NP_079198.2	COesterase	32..547	CDD:278561	171/598 (29%)
		Aes	<129..>247	CDD:223730	54/131 (41%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142621
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.790