DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and Ces2b

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_937814.1	Gene:	Ces2b / 234669	MGIID:	2448547	Length:	556	Species:	Mus musculus

Alignment Length:	566	Identity:	165/566 - (29%)
Similarity:	246/566 - (43%)	Gaps:	150/566 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 IIGHKVVQYKLGTGQTKELA-----TKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRA 76
            ::||  ||     ||....|     |..||::|............::|.|||||:||||.|||..
Mouse    20 LLGH--VQ-----GQDSPEASPIRNTHTGQVRGSLVHVKDTKAGVHTFLGIPFAKPPVGPLRFAP 77

  Fly    77 PQPPSSWQGVRDCTYAREKPMQRNSITN-------AAEGSEDCLYLNVYA-KRLESPKPLPVMVW 133
            |:.|..|.||||.|......:|...:..       ....||||||||:|. ........||||||
Mouse    78 PEAPEPWSGVRDGTAHPAMCLQNLGVMKEIKLKLPPVSTSEDCLYLNIYTPAHAHEGSNLPVMVW 142

  Fly   134 IFGGGFQVGGASRELY-GPDYFMKHDILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALR 197
            |.|||...|.||  :| |.......|:::|||.||:|||||.|..|:..:  ||.|..||:.|||
Mouse   143 IHGGGLVAGMAS--MYDGSLLAAIEDLVVVTIQYRLGVLGFFSTGDQHAR--GNWGFLDQVAALR 203

  Fly   198 WVKENIASFNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRKWPQ 262
            |:::|||.|.|.|:.:|:|||||||.|....:.:..::||||.||::||.||..:
Mouse   204 WIQQNIAHFGGKPDRVTIFGESAGGTSVSSHVVSPMSKGLFHGAIMESGVALLPY---------- 258

  Fly   263 RLGKELGYAGNLESEKELLEFFQQIPASKLAQY--CNSIVTQEEQR------DYEILAFAPVIE- 318
                             |:....::.::.:|:.  |.::.::...|      :.||||...:::
Mouse   259 -----------------LITDTSEMVSTTVAKLSGCEAMDSEALVRCLRGKSEAEILAINKLVQM 306

  Fly   319 -PYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSYRTTLDDPLYMLSA----------- 371
             |.|.|....|:..:|.|:|...:.:|.|||..:.|    :..|:  |:.|.||
Mouse   307 IPAVVDGEFFPRHPKELLASEDFHPVPSIIGVNNDE----FGWTI--PVVMGSAQTIKEITRENL 365

  Fly   372 --------FEAIIPKQVRDAIDKEELAE--------------------MVRRLKKSYFDDPDRAS 408
                    .:.::|.:..|.:.:|.:.:                    ::..|:.:|| ....||
Mouse   366 QAVLKNTTAQLMLPPECSDLLMEEYMGDTEDAQTLQIQFTEMMEDFMFVIPALQVAYF-QRSHAS 429

  Fly   409 MELYECLH-ILSIKNFWHDIHRTLLARLAYATNLPTYLYRFDMDSPHFNHYRILKCGKKVRGVCH 472
            :..||..| |.|:|    |:.             ||:: :.|                      |
Mouse   430 VYFYEFQHQIASLK----DVR-------------PTHV-KAD----------------------H 454

  Fly   473 ADDISYMF-YGILSSKLDKNSPEYRTIERLVGMWTSFATTGDPNCE 517
            ||:|.::| |.....|||....|.....|::..|.:||..|:||.|
Mouse   455 ADEIPFVFGYFFWDMKLDFTEGEKLLSRRMMKYWANFARHGNPNSE 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	161/555 (29%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	50/106 (47%)
Ces2b	NP_937814.1	COesterase	34..535	CDD:365897	158/545 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832698
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.640