Protein Alignment gas and NLGN1

DIOPT Version :9

• Sequence 1: NP_611678.1
• Gene: gas / 37572
• FlyBaseID: FBgn0034736
• Length: 566
• Species: Drosophila melanogaster
• Sequence 2: NP_001352852.1
• Gene: NLGN1 / 22871
• HGNCID: 14291
• Length: 843
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 183/631 - (29%)
• Similarity: 262/631 - (41%)
• Gaps: 179/631 - (28%)

  Fly    35 LATKYGQLKGQQRRTLYDGE---PYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCT-YAREK 95
            :||.:|:::|.::.  .:.|   |...|.|:|:|.||.||.||:.|:|||.|..:|:.| :|...
Human    55 VATNFGKIRGIKKE--LNNEILGPVIQFLGVPYAAPPTGERRFQPPEPPSPWSDIRNATQFAPVC 117

  Fly    96 PMQRNSI-------------TN--------AAEGSEDCLYLNVYAKRLESP-------------- 125
            |  :|.|             ||        ..:.||||||||:|....:.|
Human   118 P--QNIIDGRLPEVMLPVWFTNNLDVVSSYVQDQSEDCLYLNIYVPTEDGPLTKKQTDDLGDNDG 180

  Fly   126 ----------KPLPVMVWIFGGGFQVG------GASRELYGPDYFMKHDILLVTINYRVGVLGFL 174
                      .|.||||:|.||.:..|      |:....||       :::::|:|||:||||||
Human   181 AEDEDIRDSGGPKPVMVYIHGGSYMEGTGNLYDGSVLASYG-------NVIVITVNYRLGVLGFL 238

  Fly   175 SLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGESAGGASTHIL---------MQ 230
            |..|:..|  ||.||.|.||||||..|||..|.|||..|||||..|||:..::|         ..
Human   239 STGDQAAK--GNYGLLDLIQALRWTSENIGFFGGDPLRITVFGSGAGGSCVNLLTLSHYSEGNRW 301

  Fly   231 TEQARGLFHRAIVQSGSALCAWAT--QPDRKWPQRLGKELGYAGNLESEKELLEFFQQIPASKLA 293
            :...:|||.|||.|||:||.:||.  || .|:.:.|..::|.  |:....||:|..|:.|..:|
Human   302 SNSTKGLFQRAIAQSGTALSSWAVSFQP-AKYARMLATKVGC--NVSDTVELVECLQKKPYKEL- 362

  Fly   294 QYCNSIVTQEEQRDYEILAFAPVIEPYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSY 358
                  |.|:.|.....:||.|||:   ||  |||...|..:......:..:::|....|||...
Human   363 ------VDQDIQPARYHIAFGPVID---GD--VIPDDPQILMEQGEFLNYDIMLGVNQGEGLKFV 416

  Fly   359 RTTLD-DPLYMLSAFEAIIPKQVRDAIDKEELAEMVRRLKKSYFDDPDRASMELYECLHILSIKN 422
            ...:| |.....|.|:..:...|.:.....|..:::|...|..:.|
Human   417 ENIVDSDDGISASDFDFAVSNFVDNLYGYPEGKDVLRETIKFMYTD------------------- 462

  Fly   423 FWHDIH------RTLLARL--------AYAT-------NLPTYLYRFDMDSPHFNHYRILKCGKK 466
             |.|.|      :||||..        |.||       ..|||.|.|      ::|.:.    .:
Human   463 -WADRHNPETRRKTLLALFTDHQWVAPAVATADLHSNFGSPTYFYAF------YHHCQT----DQ 516

  Fly   467 V---RGVCHADDISYMFYGI--------LSSKLDKNSPEYRTIERLVGMWTSFATTGDPNCEIIA 520
            |   ....|.|::.|:. ||        ......||......:  ::..||:||.|||||..:..
Human   517 VPAWADAAHGDEVPYVL-GIPMIGPTELFPCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQPVPQ 578

  Fly   521 PVKWDPLRPGGVENCLNIADGLEFIPLPESKQFVVWDSFYTRESLY 566
            ..|:...:|...|.                   |.|..:..::.||
Human   579 DTKFIHTKPNRFEE-------------------VAWTRYSQKDQLY 605

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	178/597 (30%)
		Aes	<117..>222	CDD:223730	51/134 (38%)
NLGN1	NP_001352852.1	COesterase	53..626	CDD:365897	183/631 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142642
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740