DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and Nlgn2

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_001351066.1	Gene:	Nlgn2 / 216856	MGIID:	2681835	Length:	836	Species:	Mus musculus

Alignment Length:	624	Identity:	182/624 - (29%)
Similarity:	267/624 - (42%)	Gaps:	158/624 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 LGTGQTKE-----LATKYGQLKGQQRRTLYDGE---PYYSFEGIPFAQPPVGELRFRAPQPPSSW 83
            ||.|...|     :.|.||:::|.:|.  .:.|   |...|.|:|:|.||:|..||:.|:.|:||
Mouse    31 LGLGSLGEERFPVVNTAYGRVRGVRRE--LNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASW 93

  Fly    84 QGVRDCTYAREKPMQ-------------------RNSITNAAEGSEDCLYLNVYAKRLESP---- 125
            .|||:.|.......|                   ..:.|.....||||||||:|....:.|
Mouse    94 PGVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKK 158

  Fly   126 ------KP----------LPVMVWIFGGGFQVG------GASRELYGPDYFMKHDILLVTINYRV 168
                  .|          .|||:::.||.:..|      |:....||       ::::||:|||:
Mouse   159 RDEATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYG-------NVIVVTLNYRL 216

  Fly   169 GVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGESAGGASTHILMQTEQ 233
            |||||||..|:..|  ||.||.||||||||:.||||.|.||||.||:||..||.:..::|:.:..
Mouse   217 GVLGFLSTGDQAAK--GNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHH 279

  Fly   234 ARGLFHRAIVQSGSALCAWAT--QPDRKWPQRLGKELGYAGNLESEKELLEFFQQIPASKLAQYC 296
            :.|||.:||.|||:|:.:|:.  || .|:.:.|..::|.  :.|...|.:|..::..:.:|
Mouse   280 SEGLFQKAIAQSGTAISSWSVNYQP-LKYTRLLAAKVGC--DREDSTEAVECLRRKSSREL---- 337

  Fly   297 NSIVTQEEQRDYEILAFAPVIE-PYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGL-FSYR 359
               |.|:.|.....:||.||:: ..|.||..|...|.|.|      :..|:||....||| |...
Mouse   338 ---VDQDVQPARYHIAFGPVVDGDVVPDDPEILMQQGEFL------NYDMLIGVNQGEGLKFVED 393

  Fly   360 TTLDDPLYMLSAFEAIIPKQVRDAIDKEELAEMVRR-LKKSYFDDPDRASMELYECLHILSIKNF 423
            :...:.....|||:..:...|.:.....|..:::|. :|..|.|..||.:.|:.
Mouse   394 SAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMR----------- 447

  Fly   424 WHDIHRTLLARL--------AYAT-------NLPTYLYRFDMDSPHFNHYRILKCGKKVR----G 469
                .:||||..        |.||       ..|.|.|.|      ::|     |..:.|    .
Mouse   448 ----RKTLLALFTDHQWVAPAVATAKLHADYQSPVYFYTF------YHH-----CQAEGRPEWAD 497

  Fly   470 VCHADDISYMF-------YGILSSKLDKNSPEYRTIERLVGMWTSFATTGDPNCEIIAPVKWDPL 527
            ..|.|::.|:|       ..:......||......:  ::..||:||.|||||..:....|:...
Mouse   498 AAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAV--VMTYWTNFAKTGDPNQPVPQDTKFIHT 560

  Fly   528 RPGGVENCLNIADGLEFIPLPESKQFVVWDSFYTRESLY 566
            :|...|.                   |||..|.::|..|
Mouse   561 KPNRFEE-------------------VVWSKFNSKEKQY 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	174/589 (30%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	52/130 (40%)
Nlgn2	NP_001351066.1	COesterase	42..601	CDD:306613	178/613 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000269\|PubMed:28279354	679..699
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	791..836
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832888
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740