DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment gas and cest-30

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_504407.1	Gene:	cest-30 / 181871	WormBaseID:	WBGene00015071	Length:	578	Species:	Caenorhabditis elegans

Alignment Length:	529	Identity:	147/529 - (27%)
Similarity:	229/529 - (43%)	Gaps:	107/529 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 LYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDC-TYAREKPM-----QRNSITNAAEG 108
            :.||     :.|||||:.|||.|:|:.|.....|...||| .|....|.     ...:.:.||..
Worm    54 IVDG-----YLGIPFAKAPVGALKFKKPVAAEKWTEPRDCYEYGPGCPQTGRFAALTAKSTAAFA 113

  Fly   109 SEDCLYLNVYAKR---LESPKPLPVMVWIFGGGFQVGGASRELYGPDYFMK-----HDILLVTIN 165
            .|:||.|||:|.|   .|.||.|||:|:|:|||:::|..|   |..||.:.     .|:::||:|
Worm   114 EENCLTLNVFAPRWKLAEFPKGLPVLVYIYGGGYEIGFTS---YMDDYSLTGTLPLKDVIVVTMN 175

  Fly   166 YRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNGDPESITVFGESAGGASTHILMQ 230
            ||:|.||||::.|....  ||.||.||..||:||::|||||.|:|||:|:.|.|||..||..|..
Worm   176 YRLGPLGFLTIADGIAN--GNYGLWDQTLALQWVQDNIASFGGNPESVTLSGTSAGATSTDFLSL 238

  Fly   231 TEQARGLFHRAIVQSGSALCAWATQPDRKWPQRLG--KEL----GYAGNLESEKELLEFFQQIPA 289
            :..:..||.|:|..||:|.|.:|.:|.   ...:|  ||.    ||.|.  ..:.|.:::.....
Worm   239 SPHSNQLFQRSISMSGTAFCNFAIRPK---DVEVGVCKEFAQFQGYTGT--DSQSLFDWYMAQNV 298

  Fly   290 SKLAQYCNSIVTQEEQRDYEILAF-------APVIEPYVGDDCVIPK----------SQQEQLSS 337
            ||..               |:..|       .|.|..:.||  ..||          .:...::.
Worm   299 SKFK---------------EVAGFQSTAAGAVPFIPNFDGD--FFPKPFDILRREAPKKDALITV 346

  Fly   338 AWGNSIPMII-------GGTSFEGLFSYRTTLDDPLYMLSAFEAIIPKQVRDAIDKEELAEMVRR 395
            ....|:.|||       ...:|||..:.....|...|.....:.:....::| ::..:.|.:.||
Worm   347 VTMESVGMIIFNPLFANAYNNFEGFINETYGPDVTDYYADVKKKLTGFYLKD-VNASDKATVNRR 410

  Fly   396 LKKSYFDDPDRASMELYECLHILSIKNFWHDIHRTLLARLAYATNLPTYLYRFDMDSPHFNHYR- 459
            :       .|..|..::....:.::|::           :.|...:  ||..|:    :||...
Worm   411 V-------VDYVSDSVFNSGTLDAVKSY-----------VKYGNKV--YLGSFN----YFNDATK 451

  Fly   460 -ILKCGKKVRGVCHADDISYMFYGILSSKLDKNSPEYRTIERLVGMWTSFATTGDPNCEIIAPVK 523
             :::..:..:...|:.|..|.|...:.:.......|...::....:..:|...||||.: .....
Worm   452 DMVELMQPFKEASHSSDFKYYFGSGVMANFTPTDEEMEVMDMSGTLMANFVKYGDPNGK-SGTKP 515

  Fly   524 WDP---LRP 529
            |.|   |:|
Worm   516 WKPYTILKP 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	147/529 (28%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	54/112 (48%)
cest-30	NP_504407.1	COesterase	31..539	CDD:278561	147/529 (28%)
cest-30	NP_504407.1	Aes	<122..>230	CDD:223730	54/112 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157267
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.650