DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and cest-1.1

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_506506.1	Gene:	cest-1.1 / 179915	WormBaseID:	WBGene00011362	Length:	673	Species:	Caenorhabditis elegans

Alignment Length:	592	Identity:	156/592 - (26%)
Similarity:	249/592 - (42%)	Gaps:	134/592 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 KVVQYKLGTGQTKELATKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQG 85
            |.||...||.:.|.|...|..| |.|..|:        |.||||.:||:|:||:|.|:||.||:|
Worm    17 KRVQLSSGTIEGKILNISYSPL-GNQSATV--------FLGIPFVEPPIGDLRYRKPRPPKSWEG 72

  Fly    86 VRDCTYAREKPMQRNSIT--NAAEG--SEDCLYLNVYAKR--LESPKPLPVMVWIFGGGFQVGGA 144
            |......:...|...:.|  |...|  |||||||||....  ||: |...||:.:.|||:....|
Worm    73 VLVTNEYKSACMSNATKTYKNKFGGPISEDCLYLNVLTNEYCLEN-KNCSVMMIVHGGGYLTESA 136

  Fly   145 SRELYGPDYFMKH------DILLVTINYRVGVLGFLSLK----DKELKIPGNAGLKDQIQALRWV 199
            |  .:.|:..:.:      :|::||.|||:|:..|....    ||      |.||.|.|:::.||
Worm   137 S--TFNPEILINNFVGQGRNIVVVTFNYRLGLFSFGQFNGDRGDK------NFGLYDMIESVNWV 193

  Fly   200 KENIASFNGDPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPDRK----- 259
            :..|.:|.|:...||:.|.|||.:.......:...:||.|:.|:.|     |..|...:|
Worm   194 RREIENFGGNKNRITLAGHSAGASMIVAFTSSPLTKGLVHQQIIMS-----APMTNMSKKSNFKG 253

  Fly   260 ---WPQRLG---KELGYAGNLESEKELLEFFQQIPASKLAQYCNSIVTQEEQRDYEILAFAPVIE 318
               ..|.:|   :|:|:  |..||:::...:..:......|..::.:...:...| .|...|:.|
Worm   254 MTVMAQMVGCLSEEIGF--NKLSEEQVENTYSCLRKKSAQQILDAQLWLLQNSTY-FLGAPPIDE 315

  Fly   319 PYVGDDCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSYRTTLDDPLYMLSAFEAIIPKQVR-- 381
            .::.|   .|::.....|.   ..|..:||.|:.|        :::..|::.  .|...|:|.
Worm   316 HFLTD---YPENLYASKSI---YPINTLIGTTTLE--------VEESSYIID--PAFADKKVELL 364

  Fly   382 ----DAID---KEELAEMVRRLKKSYFDDPDRASMELYECLHILSIKNFWHDIHRTLLARLAYAT 439
                |.|.   .||.....::.:|.|.:  ..:||.|...:...:....:.|.|.        :.
Worm   365 ENLCDHIGYVLYEEPETFSKKCQKQYMN--GNSSMNLSNEMEFYTPAIDFADSHT--------SG 419

  Fly   440 NLPTYLYRFDM--DSPHFNHYRILKCGKKVRGVCHADDISYMF---YGILSSKLDKNSPEYRTIE 499
            |...:||.:|.  ..|.::.|      .:||...|::|:.|:|   .||.:.|      :| .||
Worm   420 NTKVFLYSYDYRGAGPAYDRY------LEVRSPHHSEDLIYVFGTHRGIFAPK------DY-IIE 471

  Fly   500 RLV-GMWTSFAT------TGDPNCEIIAPVKWDPLRPGGVENCLNIADGLEFIPLPESKQFV--- 554
            ::. ||:..|..      :||.        ||:.......|:.|     :.|     .|.|:
Worm   472 KIYSGMFADFVNFENPLPSGDQ--------KWNQYTKENREHFL-----INF-----DKNFITPG 518

  Fly   555 VWDSFYT 561
            :.|::||
Worm   519 MRDNYYT 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	145/553 (26%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	37/116 (32%)
cest-1.1	NP_506506.1	COesterase	19..531	CDD:278561	155/590 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157087
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740