DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment gas and cest-24

DIOPT Version :9

Sequence 1:	NP_611678.1	Gene:	gas / 37572	FlyBaseID:	FBgn0034736	Length:	566	Species:	Drosophila melanogaster
Sequence 2:	NP_504613.1	Gene:	cest-24 / 179017	WormBaseID:	WBGene00020891	Length:	658	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	181/568 - (31%)
Similarity:	269/568 - (47%)	Gaps:	85/568 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 KLGTGQTKELATKYGQLKGQQRRTLYDGEPYYSFEGIPFAQPPVGELRFRAPQPPSSWQGVRDCT 90
            |.|..:...:..:.|.|:|.:.:|. .|:....|.|||:|:||||||||:.||||.:|:|:|.|.
Worm    89 KSGKSENAIVRVQQGLLEGFRVKTA-KGDLCDVFHGIPYAEPPVGELRFQKPQPPKAWEGIRKCN 152

  Fly    91 -YAR---EKPMQRNSITNAAEGSEDCLYLNVYAKRLESPKPLPVMVWIFGGGFQVGGASRELYGP 151
             |..   .|.|..:....:|..|||||||||:|.::...|..||:.:|.|||:.:..|.|
Worm   153 KYPNRSIHKEMPWDKALPSANQSEDCLYLNVFAPKIREDKKYPVLFYIHGGGYVMDSAER----- 212

  Fly   152 DYFMKH--------DILLVTINYRVGVLGFLSLKDKELKIPGNAGLKDQIQALRWVKENIASFNG 208
             |..|:        :|::||.:||:|.|||||..|.  ..|||.||.|.::|:|||..||:||.|
Worm   213 -YTAKNICKLLVSREIIVVTFHYRLGFLGFLSTGDD--VCPGNYGLFDMLEAMRWVHANISSFGG 274

  Fly   209 DPESITVFGESAGGASTHILMQTEQARGLFHRAIVQSGSALCAWATQPD-------RKWPQRLG- 265
            |||:||:.|:|||.|:..:|..:...:|||.|.||..|::.|.|||..:       :||.:|||
Worm   275 DPENITLSGQSAGAAAADLLSFSPLTKGLFKRKIVMGGNSYCHWATTSNHDIREYCKKWAKRLGW 339

  Fly   266 -KELGYAGNLESEKELLEFFQQIPASKL--AQYCNSIVTQEEQRDYEILAFAPVIE----PYVGD 323
             .:|.||...|...::..||..:|.|||  ..:.::.:.:|.|     |..||||:    |:
Worm   340 KPQLNYANKREESVDIFNFFNGLPTSKLGMTMFFSNTIFKECQ-----LPLAPVIDGEILPH--- 396

  Fly   324 DCVIPKSQQEQLSSAWGNSIPMIIGGTSFEGLFSYRTTLDDPLYMLSAFEAIIPKQVRDAIDKEE 388
            |..:.:..||.        :|.::||..:|.|      |...:.:|...|    |::..|||...
Worm   397 DLKVLRETQEH--------VPSLVGGGEYEAL------LFCAIGLLRGTE----KEINSAIDVLS 443

  Fly   389 LAEMVRRLK------KSYFDDPD-RASMELYECLHILSIKNFWHDIHRTLLARLAYATNLPTYLY 446
            ....:.|.|      |.|.|.|. ||..:..:...:..|.:.:.:.......|......:..|.|
Worm   444 RKNRLSRSKIEAMTEKVYGDSPALRADSKARKMFFVQLISDIFANYGNYRFMRDCQQRGVECYGY 508

  Fly   447 RFDMDSPHFNHYRILKCGKKVRGVCHADDISYMF-YGILSSKLDKNSPEYRTIERLVGM----WT 506
            .||..|...  :..|:......|..|..::||:| ...:|:.|..|    :|.:.:.||    :|
Worm   509 SFDHQSKQM--WGWLQHVVPFTGGTHTSELSYLFDCNYMSAPLGMN----KTDKVVSGMTADYFT 567

  Fly   507 SFATTGDPNCEIIAPVKWDPLRPGGVENCLNIADGLEFIPLPESKQFV 554
            :|...|.||.......||:.:.|......|     :...|.||.|..|
Worm   568 NFVKFGTPNGPNSQLPKWERISPDDEHMKL-----ISIKPEPEMKTTV 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
gas	NP_611678.1	COesterase	28..534	CDD:278561	174/544 (32%)
gas	NP_611678.1	Aes	<117..>222	CDD:223730	48/112 (43%)
cest-24	NP_504613.1	COesterase	97..608	CDD:278561	177/556 (32%)
cest-24	NP_504613.1	Aes	<183..>285	CDD:223730	46/109 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R17089
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.900